Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Cytotoxic and Anti-oxidant Constituents from the Aerial Parts of Aruncus dioicus var. kamtschaticus

  • Zhao, Bing Tian (College of Pharmacy, Catholic University of Daegu) ;
  • Jeong, Su Yang (College of Pharmacy, Catholic University of Daegu) ;
  • Vu, Viet Dung (College of Pharmacy, Catholic University of Daegu) ;
  • Min, Byung Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Kim, Young Ho (Laboratory of Immunobiology, School of Life Science and Biotechnology, College of Natural Sciences, Kyungbuk National University) ;
  • Woo, Mi Hee (College of Pharmacy, Catholic University of Daegu)
  • Received : 2013.03.12
  • Accepted : 2013.03.20
  • Published : 2013.03.31
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Abstract

Ten compounds (1 - 10), palmitic acid (1), 10-nonacosanol (2), pentacosan-1-ol (3), phytol (4), ${\beta}$-sitosterol (5), ${\beta}$-sitosterol-3-O-${\beta}$-D-glucopyranoside (6), 2,4-dihydroxycinnamic acid (7), hyperoside (8), uridine (9) and adenosine (10), were isolated from the n-hexane and EtOAc-soluble fractions of the aerial parts of A. dioicus var. kamtschaticus (Rosaceae). The structures of these compounds were elucidated on the basis of spectroscopic evidence. All compounds (1 - 10) were isolated for the first time from this plant. Cytotoxicity of 1 - 10 against Jurkat T (T-lymphocytic leukemia cells), HeLa (Human cervical epitheloid carcinoma cells), MCF-7 (Human breast cancer cells), and HL-60 (Human promyelocytic leukemia cells) cell lines was measured. Compound 6 showed good cytotoxicity against HL-60 cell line with $IC_{50}$ value of 8.13 ${\mu}g/mL$. In addition, compounds 7 and 8 exhibited antioxidant activity with $IC_{50}$ values of 16.30 and 12.42 ${\mu}g/mL$, respectively.

Keywords

References

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