Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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AMPK Activators from Natural Products: A Patent Review

  • Uddin, Mohammad Nasir (Korea Bioactive Natural Material Bank, College of Pharmacy, Seoul National University) ;
  • Sharma, Govinda (Korea Bioactive Natural Material Bank, College of Pharmacy, Seoul National University) ;
  • Choi, Hong Seok (BK21 Project Team, College of Pharmacy, Chosun University) ;
  • Lim, Seong-Il (Fermentation and Functionality Research Group, Korea Food Research Institute) ;
  • Oh, Won Keun (Korea Bioactive Natural Material Bank, College of Pharmacy, Seoul National University)
  • Received : 2013.03.08
  • Accepted : 2013.03.13
  • Published : 2013.03.31
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Abstract

AMP-activated protein kinase (AMPK) is a major cellular energy sensor and master regulator of metabolic homeostasis. On activation, this cellular fuel sensing enzyme induces a series of metabolic changes to balance energy consumption via multiple downstream signaling pathways controlling nutrient uptake and energy metabolism. This pivotal role of AMPK has led to the development of numerous AMPK activators which might be used as novel drug candidates in the treatment of AMPK related disorders, diabetes, obesity, and other metabolic diseases. Consequently, a number of patents have been published on AMPK activators from natural products and other sources. This review covers the patented AMPK activators from natural products and their therapeutic potential in treatment or prevention of metabolic diseases including diabetes and obesity.

Keywords

References

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