Korean Journal of Optics and Photonics (한국광학회지)

Optical Society of Korea (한국광학회)
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Near-field Evaluation of Surface Plasmon Resonance Biosensor Sensitivity Based on the Overlap Between Field and Target Distribution

근접장-분자반응 간의 중첩을 이용한 표면 플라스몬 공명 센서 감도 평가에 관한 연구

  • Ryu, Yeonsoo (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University) ;
  • Son, Taehwang (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University) ;
  • Kim, Donghyun (School of Electrical and Electronic Engineering, Yonsei Institute of Medical Instruments Technology, Yonsei University)
  • 류연수 (연세대학교 전기전자공학부, 의료기기기술 연구소) ;
  • 손태황 (연세대학교 전기전자공학부, 의료기기기술 연구소) ;
  • 김동현 (연세대학교 전기전자공학부, 의료기기기술 연구소)
  • Received : 2013.03.18
  • Accepted : 2013.04.05
  • Published : 2013.04.25
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Abstract

In this study, we have investigated the correlation of far-field detection sensitivity of surface plasmon resonance (SPR) biosensors with optical signatures associated with the near-field overlap of biomolecules. The results confirm a direct relation between the far-field and near-field parameters, particularly for optical signatures defined in terms of lateral electric field components that are tangential to the interface and thus continuous across the interface. The overall correlation between near-field optical signatures and far-field resonance shift exceeded 97%. The results can be highly useful to evaluate detection sensitivity of SPR biosensors that take advantage of complex structures for localization of surface waves.

본 논문에서는 근접장-분자반응 간의 중첩을 이용한 표면 플라스몬 공명 (SPR) 바이오센서의 측정감도 평가방법을 연구하였다. 전달행렬 방법을 사용하여 다양한 형태의 중첩적분으로 정의된 광학자취 값을 계산하였고, 샌드위치 및 역샌드위치 면역글로뷸린 (IgG) 어세이에 대해서 실험적으로 측정된 수치와 비교하였다. 이론 및 실험적인 결과와의 비교를 통하여 접선 방향의 전기장을 사용한 광학자취의 경우 그 연속성으로 말미암아 가장 높은 상관계수를 얻을 수 있었으며 이때 광학자취와 측정감도 사이에 97% 이상의 높은 상관계수가 존재함을 보았다. 이러한 상관관계는 SPR 바이오센서의 측정 감도에 관한 메커니즘을 분명하게 설명하며, 분자 스케일 감도를 가지는 SPR 바이오센서 개발에 기여하게 될 것이다.

Keywords

References

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