Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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DNA Repair of Eukaryotes Associated with Non-coding Small RNAs

  • Kang, Han-Chul (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Yoon, Sang-Hong (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Lee, Chang-Muk (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration) ;
  • Roh, Kyung Hee (Department of metabolic engineering, National Academy of Agricultural Science, Rural Development Administration)
  • Received : 2012.10.16
  • Accepted : 2012.11.26
  • Published : 2013.03.31
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Abstract

In eukaryotes, most of the genome are transcribed, however only a small proportion of total transcripts encodes for protein, thus resulting in many of noncoding RNAs. In order to recover DNA damage including DNA double-strand breaks (DSBs) eukaryotes have evolved complex mechanisms and these are processed through coordinated mechanisms of protein sensors, transducers, and effectors including RNAs. During recent years, small RNAs have been increasingly studied and gradually considered as key regulators in various aspects of biology. Upon DNA damage, small RNAs including diRNAs (DSB induced RNA) are generated in both plant and human cell lines. Inhibition of their biogenesis has severe influence on DSB repair system.

Keywords

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