Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
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Regulatory Actions of the Cordyceps Militaris Extract on the NEFA and LCAT Activity in Diabetic Disease Model System

동충하초(Cordyceps militaris) 추출물이 당뇨성 질환 모델의 NEFA 및 LCAT 활성 조절작용에 관한 연구

  • Kim, Han-Soo (Department of Food Science & Technology, Pusan National University) ;
  • Kim, Min-A (Department of Food Science & Technology, Pusan National University) ;
  • Jang, Seong-Ho (Department of Bioenviromental Energy, Pusan National University) ;
  • Kang, Dong-Soo (Division of Food Technology & Nutrition, Chonnam National University) ;
  • Kang, Jin-Soon (School of Food Science, International University of Korea) ;
  • Lee, Won-Ki (Department of Polymer Engineering, Pukyung National University) ;
  • Lee, Chun-Sik (Department of Env. Eng. Gyeongnam National University of science and Technology)
  • 김한수 (부산대학교 식품공학과) ;
  • 김민아 (부산대학교 식품공학과) ;
  • 장성호 (부산대학교 바이오환경에너지학과) ;
  • 강동수 (전남대학교 식품공학 영양학부) ;
  • 강진순 (한국국제대학교 식품과학부) ;
  • 이원기 (부경대학교 고분자공학과) ;
  • 이춘식 (경남과학기술대학교 환경공학과)
  • Received : 2012.12.13
  • Accepted : 2013.03.19
  • Published : 2013.04.30
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Abstract

This study was conducted to investigate the effects of the Cordyceps militaris extract on the improvement of the glucide metabolism in serum of streptozotocin (STZ, 50 mg/kg BW, IP injection)-induced diabetic rats (SD strain, male) fed the experimental diets for 5 weeks. Concentrations of creatinine, lipid peroxide and NEFA in sera were significantly higher in the STZ-induced diabetic group (group DMG) and STZ+Cordyceps militaris extract administration group (group DMS) than those in the control group (group BD). However, the concentrations of creatinine, lipid peroxide and NEFA in sera were reduced in the group DMS than those in the group DMG. The activity of creatine phosphokinase (CPK) in serum was lower in the group DMS than in the group DMG. The activity of LCAT in serum was increased in the group DMS (Cordyceps militaris extract administration) than in the group DMG. The results indicate that Cordyceps militaris extract were effective in the improvement of the glucide metabolism in the sera of STZ-induced diabetic rats.

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References

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