Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)
- Volume 11 Issue 2
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- Pages.119-126
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- 2013
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
Clinical Analysis of Patients with Cardiotoxicity Caused by Himalayan Mad Honey
히말라야산 석청 복용 후 발생한 심장독성 환자들의 임상적 특성 분석
- Kim, Sung Ho (Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
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Seo, Dong Woo
(Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
- Ryoo, Seung Mok (Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
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Kim, Won Young
(Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
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Oh, Bum Jin
(Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
- Lim, Kyoung Soo (Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center) ;
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Sohn, Chang Hwan
(Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center)
- 김성호 (울산대학교 의과대학 서울아산병원 응급의학교실) ;
-
서동우
(울산대학교 의과대학 서울아산병원 응급의학교실) ;
- 유승목 (울산대학교 의과대학 서울아산병원 응급의학교실) ;
-
김원영
(울산대학교 의과대학 서울아산병원 응급의학교실) ;
-
오범진
(울산대학교 의과대학 서울아산병원 응급의학교실) ;
- 임경수 (울산대학교 의과대학 서울아산병원 응급의학교실) ;
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손창환
(울산대학교 의과대학 서울아산병원 응급의학교실)
- Received : 2013.09.17
- Accepted : 2013.10.22
- Published : 2013.12.31
Abstract
Purpose: The aim of this study was to evaluate the clinical characteristics and outcome of patients who presented to the emergency department (ED) with cardiotoxicity caused by ingestion of Himalayan mad honey. Methods: Medical records of 12 patients who presented to the ED from January 1, 2005 to December 31, 2012 with cardiotoxicity caused by ingestion of Himalayan mad honey were retrospectively reviewed. Results: The mean age of patients was 54.5 years and 58.3% were men. The median amount of mad honey ingested was 30.0 cc, and the mean time from ingestion to onset of symptoms was 39.4 minutes. All patients had hypotension and bradycardia upon arrival in the ED. The initial electrocardiogram showed sinus bradycardia in seven patients, junctional bradycardia in four patients, and atrial fibrillation with slow ventricular response in one patient. Four patients were treated with intravenous normal saline solution only. Eight patients were treated with intravenous normal saline solution and atropine sulfate in a dose ranging from 0.5 to 2.0 mg. Blood pressure and pulse rate returned to normal limits within 24 hours in all patients. Conclusion: Our study showed that all patients with cardiotoxicity caused by ingestion of Himalayan mad honey had severe hypotension, bradycardia, and bradyarrythmias, including sinus bradycardia and junctional bradycardia and all patients responded well to conservative treatment, including intravenous normal saline solution and intravenous atropine sulfate.