Diabetic Neuropathy

당뇨 신경병증

  • Shim, Jung-In (Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea) ;
  • Chung, Jin-Wha (Department of Orthopedic Surgery, Yeouido St. Mary's Hospital, Catholic University of Korea)
  • 심정인 (가톨릭대학교 의과대학 여의도성모병원 정형외과학교실) ;
  • 정진화 (가톨릭대학교 의과대학 여의도성모병원 정형외과학교실)
  • Received : 2013.10.30
  • Accepted : 2013.11.12
  • Published : 2013.12.15

Abstract

Neuropathy is a common complication of diabetes. It is characterized by a progressive loss of peripheral nerve fibers. The development of the neuropathy is linked to poor glycemic control, age, and the duration of diabetes. Peripheral sensory polyneuropathy is the most common type in neuropathy. Diabetic neuropathy is the most significant etiologic factor of the foot ulcer that may leads to amputation. Current treatments in diabetic neuropathy have no definitive effects on repair or reverse the damaged nerve but only to relieve of symptoms, especially on pain. When the focal compressive neuropathy is combined with diabetic neuropathy, the nerve would be more vulnerable and symptoms might get worse. Surgery is indicated for decompression of an entrapped nerve, like posterior tibial nerve in tarsal tunnel, after failure of the initial conservative treatments.

Keywords

References

  1. Boulton AJ, Malik RA, Arezzo JC, Sosenko JM. Diabetic somatic neuropathies. Diabetes Care. 2004;27:1458-86. https://doi.org/10.2337/diacare.27.6.1458
  2. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27:1047-53. https://doi.org/10.2337/diacare.27.5.1047
  3. Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000;47:123-8. https://doi.org/10.1016/S0168-8227(99)00112-6
  4. Rathur HM, Boulton AJM. Recent advances in the diagnosis and management of diabetic neuropathy. J Bone Joint Surg Br. 2005;87:1605-10.
  5. Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. J Vasc Surg. 2011;53:220-6. https://doi.org/10.1016/j.jvs.2010.06.100
  6. Sertoz N, Deniz MN, Ayanoglu HO. Relationship between glycosylated hemoglobin level and sciatic nerve block performance in diabetic patients. Foot Ankle Int. 2013;34: 85-90. https://doi.org/10.1177/1071100712460366
  7. Tesfaye S, Stevens LK, Stephenson JM, et al. Prevalence of diabetic peripheral neuropathy and its relation to glycaemic control and potential risk factors: the EURODIAB IDDM Complications Study. Diabetologia. 1996;39:1377-84. https://doi.org/10.1007/s001250050586
  8. D'Ambrogi E, Giacomozzi C, Macellari V, Uccioli L. Abnormal foot function in diabetic patients: the altered onset of Windlass mechanism. Diabet Med. 2005;22:1713-9. https://doi.org/10.1111/j.1464-5491.2005.01699.x
  9. Carlson RE, Fleming LL, Hutton WC. The biomechanical relationship between the tendoachilles, plantar fascia and metatarsophalangeal joint dorsiflexion angle. Foot Ankle Int. 2000;21:18-25. https://doi.org/10.1177/107110070002100104
  10. Duffin AC, Lam A, Kidd R, Chan AK. Ultrasonography of plantar soft tissues thickness in young people with diabetes. Diabet Med. 2002;19:1009-13. https://doi.org/10.1046/j.1464-5491.2002.00850.x
  11. Gondring WH, Shields B. A touch pressure sensory assessment of the surgical treatment of the tarsal tunnel syndrome. Foot Ankle Surg. 2011;17:266-9. https://doi.org/10.1016/j.fas.2010.08.010
  12. Rader AJ, Barry TP, Stanley OL. Characteristics of lower extremity pressure sensation impairment in developing diabetic sensory polyneuropathy. Foot Ankle Spec. 2008;1:39-45. https://doi.org/10.1177/1938640007312383.
  13. Backonja M, Beydoun A, Edwards KR, et al. Gabapentin for the symptomatic treatment of painful neuropathy in patients with diabetes mellitus: a randomized controlled trial. JAMA. 1998;280:1831-6. https://doi.org/10.1001/jama.280.21.1831
  14. Fudin J, Audette CM. Gabapentin vs amitriptyline for the treatment of peripheral neuropathy. Arch Intern Med. 2000;160:1040-6. https://doi.org/10.1001/archinte.160.7.1040
  15. Harati Y, Gooch C, Swenson M, et al. Maintenance of the long-term effectiveness of tramadol in treatment of the pain of diabetic neuropathy. J Diabetes Complications. 2000;14: 65-70. https://doi.org/10.1016/S1056-8727(00)00060-X
  16. Scheffler NM, Sheitel PL, Lipton MN. Treatment of painful diabetic neuropathy with capsaicin 0.075%. J Am Podiatr Med Assoc. 1991;81:288-93. https://doi.org/10.7547/87507315-81-6-288
  17. Baravarian B. Surgical Decompression for Painful Diabetic Peripheral Nerve Compression and Neuropathy: A Comprehensive Approach to a Potential Surgical Problem. Clin Pod Med Surg. 2006;23:621-35. https://doi.org/10.1016/j.cpm.2006.05.003
  18. Dellon AL. Diabetic Neuropathy: Medical and Surgical Approaches. Clin Pod Med Surg. 2007;24:425-48. https://doi.org/10.1016/j.cpm.2007.03.003
  19. Ahmad M, Tsang K. Tarsal tunnel syndrome: A literature review. Foot Ankle Surg. 2012;18:149-52. https://doi.org/10.1016/j.fas.2011.10.007