Asian Pacific Journal of Cancer Prevention

  • 제14권1호
  • /
  • Pages.231-236
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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XPD Lys751Gln and Asp312Asn Polymorphisms and Gastric Cancer Susceptibility: A Meta-analysis of Case-control Studies

  • Yin, Qing-Hua (Department of Oncology, the First People's Hospital of Yueyang) ;
  • Liu, Chuan (Department of Oncology, Changhai Hospital, the Second Military Medical University) ;
  • Hu, Jian-Bing (Department of Oncology, the First People's Hospital of Yueyang) ;
  • Meng, Rong-Rong (Department of Oncology, Changhai Hospital, the Second Military Medical University) ;
  • Li, Lian (Yueyang Second People's Hospital) ;
  • Wang, Ya-Jie (Department of Oncology, Changhai Hospital, the Second Military Medical University)
  • 발행 : 2013.01.31
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초록

Background: Published data regarding the association between xeroderma pigmentosum group D (XPD) Lys751Gln and Asp312Asn polymorphisms and gastric cancer susceptibility havew been inconclusive. This meta-analysis was therefore performed toobtain a more precise estimation of any relationship. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of Lys751Gln and Asp312Asn polymorphisms and susceptibility to gastric cancer. Summary odds ratios (ORs) and its 95% confidence intervals (95% CIs) were calculated using a random-effects model with the software STATA (version10.0). Results: A total of 12 case-control studies including 3,147 cases and 4,736 controls were included. Overall, no significant associations were found in some models (for Lys751Gln: Lys/Gln vs Lys/Lys: OR=1.144, 95% CI=0.851-1.541, Gln/Gln vs Lys/Lys: OR=1.215, 95% CI = 0.740-1.955, dominant model: OR=1.137, 95% CI=0.818-1.582; recessive model: OR=1.123, 95% CI=0.765-1.650; for Asp312Asn: Asp/Asn vs Asp/Asp: OR=1.180, 95% CI=0.646-2.154, dominant model: OR=1.380, 95% CI = 0.812-2.346), but significantly elevated susceptibility was found for Asp312Asn polymorphism in some models (Asn/Asn vs Asp/Asp: OR=2.045, 95% CI=1.254-3.335, recessive model: OR=1.805, 95% CI =1.219-2.672), for the additive model, the XPD Lys751Gln and Asp312Asn polymorphisms were not significantly associated with gastric cancer susceptibility. In stratified analyses, significantly elevated susceptibility was found for some models in the Chinese population. Conclusion: This meta-analysis suggested the XPD Asp312Asn polymorphism might be a potential biomarker of gastric cancer susceptibility in overall population, while both XPD Lys751Gln and Asp312Asn polymorphisms might be risk factors of gastric cancer susceptibility in Chinese.

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피인용 문헌

  1. XPD Lys751Gln and Asp312Asn Polymorphisms and Susceptibility to Skin Cancer: A Meta-Analysis of 17 Case-control Studies vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6619
  2. XPD Asp312Asn and Lys751Gln polymorphisms and breast cancer susceptibility: A meta-analysis vol.35, pp.3, 2014, https://doi.org/10.1007/s13277-013-1256-3
  3. The -786T > C polymorphism in the NOS3 gene is associated with increased cancer risk vol.35, pp.4, 2014, https://doi.org/10.1007/s13277-013-1467-7
  4. XPD Lys751Gln and Asp312Asn polymorphisms and hepatocellular carcinoma susceptibility: A meta-analysis of 11 case-control studies in an Asian population vol.9, pp.6, 2015, https://doi.org/10.3892/etm.2015.2421
  5. and the Risk of Prostate Cancer pp.1533-0338, 2017, https://doi.org/10.1177/1533034617724678
  6. Asp312Asn with Lung Cancer Risk: Evidence from 20,101 Subjects vol.18, pp.1, 2014, https://doi.org/10.1089/gtmb.2013.0296