The Korean Journal of Medicine

  • 제84권3호
  • /
  • Pages.457-463
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  • 2013
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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폐쇄세기관지기질화폐렴이 합병된 피부근염 환자에서 동반된 전립샘암 1예

A Case of Prostate Cancer Associated with Dermatomyositis and Interstitial Lung Disease

  • 강종완 (경북대학교 의학전문대학원 내과학교실) ;
  • 은정수 (경북대학교 의학전문대학원 내과학교실) ;
  • 김나리 (경북대학교 의학전문대학원 내과학교실) ;
  • 임철현 (경북대학교 의학전문대학원 내과학교실) ;
  • 강영모 (경북대학교 의학전문대학원 내과학교실) ;
  • 남언정 (경북대학교 의학전문대학원 내과학교실)
  • Kang, Jong Wan (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine) ;
  • Eun, Jung Su (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine) ;
  • Kim, Na Ri (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine) ;
  • Im, Churl Hyun (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine) ;
  • Kang, Young Mo (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine) ;
  • Nam, Eon Jeong (Department of Internal Medicine, Kyoungpook National Universitiy School of Medicine)
  • 투고 : 2012.08.13
  • 심사 : 2012.10.18
  • 발행 : 2013.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

피부근염 환자에서 악성종양 동반율이 높다고 알려져 있으며, 일반적으로 고령, 피부괴사, 연하곤란, 간질성 폐질환 부재 등의 악성종양 예측인자가 있는 경우에 악성종양에 대한 철저한 스크리닝 검사를 실시하도록 권유되고 있다. 전립샘암이 피부근염에 동반된 경우는 매우 드물게 보고되어 있으며, 본 증례와 같이 간질성 폐질환의 일종인 폐쇄세기관지 기질화폐렴이 합병된 피부근염에 전립샘암이 동반된 경우는 국내에 보고된 바가 없다. 최근 국내 전립샘암의 유병률 및 발생률이 빠르게 증가하고 있으며 전립샘암이 다양한 신생물딸림증후군을 흔하게 동반하므로, 중년 이상의 남성 환자에서 피부근염이 진단된 경우에는 전립샘암의 동반 가능성을 확인해 보아야 할 것이다.

Dermatomyositis (DM) is a kind of systemic autoimmune disease characterized by chronic inflammation leading to progressive weakness of proximal muscles and typical cutaneous lesions. DM has been known to be strongly associated with malignancies, such as ovarian, lung, and gastric cancers. Prostate cancer is rarely associated with DM and, to our knowledge, no case of prostate cancer has been reported in patients with DM combined with interstitial lung disease in Korea. Here, we report a case of DM with bronchiolitis obliterans organizing pneumonia that was simultaneously diagnosed as advanced prostate cancer by a thorough evaluation for hidden malignancy.

키워드

참고문헌

  1. Hill CL, Zhang Y, Sigurgeirsson B, et al. Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet 2001;357:96-100. https://doi.org/10.1016/S0140-6736(00)03540-6
  2. So MW, Koo BS, Kim YG, Lee CK, Yoo B. Idiopathic inflammatory myopathy associated with malignancy: a retrospective cohort of 151 Korean patients with dermatomyositis and polymyositis. J Rheumatol 2011;38: 2432-2435. https://doi.org/10.3899/jrheum.110320
  3. Danko K, Ponyi A, Molnar AP, Andras C, Constantin T. Paraneoplastic myopathy. Curr Opin Rheumatol 2009;21: 594-598. https://doi.org/10.1097/BOR.0b013e3283317fa5
  4. Wakata N, Kurihara T, Saito E, Kinoshita M. Polymyositis and dermatomyositis associated with malignancy: a 30-year retrospective study. Int J Dermatol 2002;41:729-734. https://doi.org/10.1046/j.1365-4362.2002.01648.x
  5. Fardet L, Dupuy A, Gain M, et al. Factors associated with underlying malignancy in a retrospective cohort of 121 patients with dermatomyositis. Medicine (Baltimore) 2009;88:91-97. https://doi.org/10.1097/MD.0b013e31819da352
  6. Hong MK, Kong J, Namdarian B, et al. Paraneoplastic syndromes in prostate cancer. Nat Rev Urol 2010;7: 681-692. https://doi.org/10.1038/nrurol.2010.186
  7. Tallai B, Flasko T, Gyorgy T, et al. Prostate cancer underlying acute, definitive dermatomyositis: successful treatment with radical perineal prostatectomy. Clin Rheumatol 2006;25:119-120. https://doi.org/10.1007/s10067-005-1130-9
  8. Kim HY, Kwok SK, Kim WU. A case of dermatomyositis associated with prostate cancer. J Korean Rheum Assoc 2009;16:59-63. https://doi.org/10.4078/jkra.2009.16.1.59
  9. Choi KS, Park JK. Epidemiologic characteristics of prostate cancer detection. Korean J Urol 2009;50:1054-1058. https://doi.org/10.4111/kju.2009.50.11.1054
  10. Connors GR, Christopher-Stine L, Oddis CV, Danoff SK. Interstitial lung disease associated with the idiopathic inflammatory myopathies: what progress has been made in the past 35 years? Chest 2010;138:1464-1474. https://doi.org/10.1378/chest.10-0180