The Korean Journal of Medicine

  • 제84권3호
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  • Pages.395-399
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  • 2013
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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대변 세균총 이식으로 치료된 난치성 위막성 대장염 2예

Two Cases of Refractory Pseudomembranous Colitis that Healed Following Fecal Microbiota Transplantation

  • 권태근 (가톨릭대학교 의과대학 내과학교실) ;
  • 최명규 (가톨릭대학교 의과대학 내과학교실) ;
  • 이순규 (가톨릭대학교 의과대학 내과학교실) ;
  • 하정훈 (가톨릭대학교 의과대학 내과학교실) ;
  • 김은영 (가톨릭대학교 의과대학 내과학교실) ;
  • 고병성 (가톨릭대학교 의과대학 내과학교실) ;
  • 김상우 (가톨릭대학교 의과대학 내과학교실)
  • Gweon, Tae Geun (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Choi, Myung Gyu (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Lee, Soon Kyu (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Ha, Jeong Hoon (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Eun Young (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Go, Byoung Soung (Department of Internal Medicine, The Catholic University of Korea College of Medicine) ;
  • Kim, Sang Woo (Department of Internal Medicine, The Catholic University of Korea College of Medicine)
  • 투고 : 2012.06.27
  • 심사 : 2012.09.28
  • 발행 : 2013.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

항생제에 반응하지 않는 난치성, 재발성의 위막성 대장염 환자 2명에 대해 대변 세균총 이식을 통해 치료하였기에 문헌고찰과 함께 보고하는 바이다.

The incidence, recurrence, and mortality of Clostridium difficile infection are increasing and the standard therapy is oral metronidazole or vancomycin. Since treatment failure with standard therapy is increasing, an alternative therapy is needed. Fecal microbiota transplantation is one effective method in patients with refractory or recurrent C. difficile infection, including pseudomembranous colitis. Here, we report two cases of refractory pseudomembranous colitis treated with fecal microbiota transplantation.

키워드

참고문헌

  1. Cohen SH, Gerding DN, Johnson S, et al. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA). Infect Control Hosp Epidemiol 2010;31: 431-455. https://doi.org/10.1086/651706
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  7. Gough E, Shaikh H, Manges AR. Systematic review of intestinal microbiota transplantation (fecal bacteriotherapy) for recurrent Clostridium difficile infection. Clin Infect Dis 2011;53:994-1002. https://doi.org/10.1093/cid/cir632
  8. Hamilton MJ, Weingarden AR, Sadowsky MJ, Khoruts A. Standardized frozen preparation for transplantation of fecal microbiota for recurrent Clostridium difficile infection. Am J Gastroenterol 2012;107:761-767. https://doi.org/10.1038/ajg.2011.482
  9. Mattila E, Uusitalo-Seppälä R, Wuorela M, et al. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology 2012;142:490-496. https://doi.org/10.1053/j.gastro.2011.11.037
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피인용 문헌

  1. Successful Fecal Transplantation by Enema for Recurrent and Refractory Clostridium difficile Infection vol.17, pp.3, 2013, https://doi.org/10.4235/jkgs.2013.17.3.152
  2. What's New in the Management of Bacterial Infections in the Era of Multidrug-Resistant Bacteria? vol.27, pp.3, 2013, https://doi.org/10.4285/jkstn.2013.27.3.81
  3. Refractory Clostridium difficile Infection Cured With Fecal Microbiota Transplantation in Vancomycin-Resistant Enterococcus Colonized Patient vol.13, pp.1, 2013, https://doi.org/10.5217/ir.2015.13.1.80
  4. Fecal Microbiota Transplantation Using Upper Gastrointestinal Tract for the Treatment of Refractory or Severe Complicated Clostridium difficile Infection in Elderly Patients in Poor Medical Conditio vol.2016, pp.None, 2013, https://doi.org/10.1155/2016/2687605
  5. Fecal Transplantation using a Nasoenteric Tube during an Initial Episode of Severe Clostridium difficile Infection vol.48, pp.1, 2013, https://doi.org/10.3947/ic.2016.48.1.31
  6. Refractory pseudomembranous colitis that was treated successfully with colonoscopic fecal microbial transplantation vol.14, pp.1, 2013, https://doi.org/10.5217/ir.2016.14.1.83
  7. Fecal Microbiota Transplantation: Current Applications, Effectiveness, and Future Perspectives vol.49, pp.3, 2016, https://doi.org/10.5946/ce.2015.117