The Korean Journal of Medicine

  • 제84권3호
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  • Pages.325-332
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  • 2013
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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간선종과 국소결절성과증식

Hepatocellular Adenoma and Focal Nodular Hyperplasia

  • 김원 (서울대학교 의과대학 내과학교실, 서울특별시 보라매병원 소화기내과)
  • Kim, Won (Department of Internal Medicine, Seoul Metropolitan Government Boramae Medical Center, Seoul National University College of Medicine)
  • 발행 : 2013.03.01
⟨ 이전 논문 다음 논문 ⟩

초록

Recent advances in imaging technologies have offered us a great chance to detect a variety of focal liver lesions. Accordingly, it is of paramount importance to determine whether these focal liver lesions are malignant or nonmalignant. Some benign hepatic tumors mimicking hepatocellular carcinoma typically develop from either regenerative or dysplastic/neoplastic processes. The most common benign hepatic solid tumors that are not of vascular origin include focal nodular hyperplasia and hepatocellular adenoma. A majority of patients with benign hepatic tumors are often asymptomatic and require no specific treatment. However, surgical resection may be infrequently needed for cases with clinical symptoms or malignant potential. This review will touch on the epidemiology, pathogenesis, clinical features, diagnosis, and management of focal nodular hyperplasia and hepatocellular adenoma.

키워드

참고문헌

  1. Grazioli L, Federle MP, Brancatelli G, Ichikawa T, Olivetti L, Blachar A. Hepatic adenomas: imaging and pathologic findings. Radiographics 2001;21:877-892. https://doi.org/10.1148/radiographics.21.4.g01jl04877
  2. Sherlock S. Hepatic adenomas and oral contraceptives. Gut 1975;16:753-756. https://doi.org/10.1136/gut.16.9.753
  3. Klatskin G. Hepatic tumors: possible relationship to use of oral contraceptives. Gastroenterology 1977;73:386-394.
  4. Baum JK, Bookstein JJ, Holtz F, Klein EW. Possible association between benign hepatomas and oral contraceptives. Lancet 1973;2:926-929.
  5. Edmondson HA, Henderson B, Benton B. Liver-cell adenomas associated with use of oral contraceptives. N Engl J Med 1976;294:470-472. https://doi.org/10.1056/NEJM197602262940904
  6. Rooks JB, Ory HW, Ishak KG, et al. Epidemiology of hepatocellular adenoma: the role of oral contraceptive use. JAMA 1979;242:644-648. https://doi.org/10.1001/jama.1979.03300070040020
  7. Nime F, Pickren JW, Vana J, Aronoff BL, Baker HW, Murphy GP. The histology of liver tumors in oral contraceptive users observed during a national survey by the American College of Surgeons Commission on Cancer. Cancer 1979;44:1481-1489. https://doi.org/10.1002/1097-0142(197910)44:4<1481::AID-CNCR2820440443>3.0.CO;2-1
  8. Rosenberg L. The risk of liver neoplasia in relation to combined oral contraceptive use. Contraception 1991;43: 643-652. https://doi.org/10.1016/0010-7824(91)90007-3
  9. Soe KL, Soe M, Gluud C. Liver pathology associated with the use of anabolic-androgenic steroids. Liver 1992;12: 73-79. https://doi.org/10.1055/s-2007-1007378
  10. Reddy KR, Schiff ER. Approach to a liver mass. Semin Liver Dis 1993;13:423-435.
  11. Shortell CK, Schwartz SI. Hepatic adenoma and focal nodular hyperplasia. Surg Gynecol Obstet 1991;173:426-431.
  12. Meissner K. Hemorrhage caused by ruptured liver cell adenoma following long-term oral contraceptives: a case report. Hepatogastroenterology 1998;45:224-225.
  13. Edmondson HA, Reynolds TB, Henderson B, Benton B. Regression of liver cell adenomas associated with oral contraceptives. Ann Intern Med 1977;86:180-182. https://doi.org/10.7326/0003-4819-86-2-180
  14. Kawakatsu M, Vilgrain V, Erlinger S, Nahum H. Disappearance of liver cell adenoma: CT and MR imaging. Abdom Imaging 1997;22:274-276. https://doi.org/10.1007/s002619900188
  15. Aseni P, Sansalone CV, Sammartino C, et al. Rapid disappearance of hepatic adenoma after contraceptive withdrawal. J Clin Gastroenterol 2001;33:234-236. https://doi.org/10.1097/00004836-200109000-00015
  16. Maillette de Buy Wenniger L, Terpstra V, Beuers U. Focal nodular hyperplasia and hepatic adenoma: epidemiology and pathology. Dig Surg 2010;27:24-31. https://doi.org/10.1159/000268404
  17. Scheuer P, Lefkowitch J. Neoplasms and nodules. In: Scheuer PJ, Lefkowitch JH, eds. Liver Biopsy Interpretation. 6th ed. London: WB Saunders, 2000:191.
  18. Zucman-Rossi J, Jeannot E, Nhieu JT, et al. Genotypephenotype correlation in hepatocellular adenoma: new classification and relationship with HCC. Hepatology 2006;43:515-524. https://doi.org/10.1002/hep.21068
  19. Laumonier H, Bioulac-Sage P, Laurent C, Zucman-Rossi J, Balabaud C, Trillaud H. Hepatocellular adenomas: magnetic resonance imaging features as a function of molecular pathological classification. Hepatology 2008;48:808-818. https://doi.org/10.1002/hep.22417
  20. Ronot M, Bahrami S, Calderaro J, et al. Hepatocellular adenomas: accuracy of magnetic resonance imaging and liver biopsy in subtype classification. Hepatology 2011;53: 1182-1191. https://doi.org/10.1002/hep.24147
  21. Leese T, Farges O, Bismuth H. Liver cell adenomas. A 12-year surgical experience from a specialist hepato-biliary unit. Ann Surg 1988;208:558-564. https://doi.org/10.1097/00000658-198811000-00003
  22. Nagorney DM. Benign hepatic tumors: focal nodular hyperplasia and hepatocellular adenoma. World J Surg 1995;19:13-18. https://doi.org/10.1007/BF00316973
  23. Rubin RA, Mitchell DG. Evaluation of the solid hepatic mass. Med Clin North Am 1996;80:907-928. https://doi.org/10.1016/S0025-7125(05)70473-9
  24. Cherqui D, Rahmouni A, Charlotte F, et al. Management of focal nodular hyperplasia and hepatocellular adenoma in young women: a series of 41 patients with clinical, radiological, and pathological correlations. Hepatology 1995;22: 1674-1681. https://doi.org/10.1002/hep.1840220610
  25. Kerlin P, Davis GL, McGill DB, Weiland LH, Adson MA, Sheedy PF 2nd. Hepatic adenoma and focal nodular hyperplasia: clinical, pathologic, and radiologic features. Gastroenterology 1983;84(5 Pt 1):994-1002.
  26. Foster JH, Berman MM. The malignant transformation of liver cell adenomas. Arch Surg 1994;129:712-717. https://doi.org/10.1001/archsurg.1994.01420310044007
  27. Chung KY, Mayo-Smith WW, Saini S, Rahmouni A, Golli M, Mathieu D. Hepatocellular adenoma: MR imaging features with pathologic correlation. AJR Am J Roentgenol 1995;165:303-308. https://doi.org/10.2214/ajr.165.2.7618545
  28. Paulson EK, McClellan JS, Washington K, Spritzer CE, Meyers WC, Baker ME. Hepatic adenoma: MR characteristics and correlation with pathologic findings. AJR Am J Roentgenol 1994;163:113-116. https://doi.org/10.2214/ajr.163.1.8010195
  29. Arrive L, Flejou JF, Vilgrain V, et al. Hepatic adenoma: MR findings in 51 pathologically proved lesions. Radiology 1994;193:507-512. https://doi.org/10.1148/radiology.193.2.7972769
  30. Grazioli L, Morana G, Kirchin MA, Schneider G. Accurate differentiation of focal nodular hyperplasia from hepatic adenoma at gadobenate dimeglumine-enhanced MR imaging: prospective study. Radiology 2005;236:166-177. https://doi.org/10.1148/radiol.2361040338
  31. Grazioli L, Bondioni MP, Haradome H, et al. Hepatocellular adenoma and focal nodular hyperplasia: value of gadoxetic acid-enhanced MR imaging in differential diagnosis. Radiology 2012;262:520-529. https://doi.org/10.1148/radiol.11101742
  32. Dokmak S, Paradis V, Vilgrain V, et al. A single-center surgical experience of 122 patients with single and multiple hepatocellular adenomas. Gastroenterology 2009;137: 1698-1705. https://doi.org/10.1053/j.gastro.2009.07.061
  33. Bioulac-Sage P, Laumonier H, Couchy G, et al. Hepatocellular adenoma management and phenotypic classification: the Bordeaux experience. Hepatology 2009;50: 481-489. https://doi.org/10.1002/hep.22995
  34. Sherlock S. Hepatic reactions to drugs. Gut 1979;20: 634-648. https://doi.org/10.1136/gut.20.7.634
  35. Monks PL, Fryar BG, Biggs WW. Spontaneous rupture of an hepatic adenoma in pregnancy with survival of mother and fetus. Aust N Z J Obstet Gynaecol 1986;26:155-157. https://doi.org/10.1111/j.1479-828X.1986.tb01555.x
  36. Estebe JP, Malledant Y, Guillou YM, et al. Spontaneous rupture of an adenoma of the liver during pregnancy. J Chir (Paris) 1988;125:654-656.
  37. Terkivatan T, de Wilt JH, de Man RA, Ijzermans JN. Management of hepatocellular adenoma during pregnancy. Liver 2000;20:186-187. https://doi.org/10.1034/j.1600-0676.2000.020002186.x
  38. Belghiti J, Pateron D, Panis Y, et al. Resection of presumed benign liver tumours. Br J Surg 1993;80:380-383. https://doi.org/10.1002/bjs.1800800340
  39. Mueller J, Keeffe EB, Esquivel CO. Liver transplantation for treatment of giant hepatocellular adenomas. Liver Transpl Surg 1995;1:99-102. https://doi.org/10.1002/lt.500010205
  40. Tepetes K, Selby R, Webb M, Madariaga JR, Iwatsuki S, Starzl TE. Orthotopic liver transplantation for benign hepatic neoplasms. Arch Surg 1995;130:153-156. https://doi.org/10.1001/archsurg.1995.01430020043005
  41. Yoshidome H, McMasters KM, Edwards MJ. Management issues regarding hepatic adenomatosis. Am Surg 1999;65: 1070-1076.
  42. Azagra JS, Goergen M, Gilbart E, Jacobs D. Laparoscopic anatomical (hepatic) left lateral segmentectomy-technical aspects. Surg Endosc 1996;10:758-761. https://doi.org/10.1007/BF00193052
  43. Eckhauser FE, Knol JA, Raper SE, Thompson NW. Enucleation combined with hepatic vascular exclusion is a safe and effective alternative to hepatic resection for liver cell adenoma. Am Surg 1994;60:466-471.
  44. Wheeler PG, Melia W, Dubbins P, et al. Non-operative arterial embolisation in primary liver tumours. Br Med J 1979;2:242-244. https://doi.org/10.1136/bmj.2.6184.242
  45. Ault GT, Wren SM, Ralls PW, Reynolds TB, Stain SC. Selective management of hepatic adenomas. Am Surg 1996;62:825-829.
  46. Edmondson HA. Tumors of the liver and intrahepatic bile duct. In: Hartmann WH, Cowan WR, eds. Atlas of Tumor Pathology, Fascicle 25. Washington, D.C.: Armed Forces Institute of Pathology, 1958:19-29.
  47. Terminology of nodular hepatocellular lesions: International Working Party. Hepatology 1995;22:983-993. https://doi.org/10.1002/hep.1840220341
  48. Craig JR, Peters RL, Edmondson HA. Tumors of the liver and intrahepatic bile ducts. In: Hartmann WH, Sobin LH, eds. Atlas of Tumor Pathology, 2nd Series, Fascicle 26. Washington, D.C.: Armed Forces Institute of Pathology, 1989:56-62.
  49. Wanless IR. Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2,500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 1990;11:787-797. https://doi.org/10.1002/hep.1840110512
  50. Wanless IR, Albrecht S, Bilbao J, et al. Multiple focal nodular hyperplasia of the liver associated with vascular malformations of various organs and neoplasia of the brain: a new syndrome. Mod Pathol 1989;2:456-462.
  51. Wanless IR, Mawdsley C, Adams R. On the pathogenesis of focal nodular hyperplasia of the liver. Hepatology 1985; 5:1194-1200. https://doi.org/10.1002/hep.1840050622
  52. Vilgrain V, Uzan F, Brancatelli G, Federle MP, Zappa M, Menu Y. Prevalence of hepatic hemangioma in patients with focal nodular hyperplasia: MR imaging analysis. Radiology 2003;229:75-79. https://doi.org/10.1148/radiol.2291021284
  53. Kang HY, La SS, Kong JH, et al. Clinical, radiological and pathological exploration of focal nodular hyperplasia of liver reported in Korea. Korean J Gastroenterol 2008;52: 376-383.
  54. Fukukura Y, Nakashima O, Kusaba A, Kage M, Kojiro M. Angioarchitecture and blood circulation in focal nodular hyperplasia of the liver. J Hepatol 1998;29:470-475. https://doi.org/10.1016/S0168-8278(98)80067-6
  55. Kondo F, Nagao T, Sato T, et al. Etiological analysis of focal nodular hyperplasia of the liver, with emphasis on similar abnormal vasculatures to nodular regenerative hyperplasia and idiopathic portal hypertension. Pathol Res Pract 1998; 194:487-495. https://doi.org/10.1016/S0344-0338(98)80117-9
  56. Sato Y, Harada K, Ikeda H, et al. Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver: a potential mechanism of central scar formation. Hum Pathol 2009;40:181-188. https://doi.org/10.1016/j.humpath.2008.04.024
  57. Nguyen BN, Flejou JF, Terris B, Belghiti J, Degott C. Focal nodular hyperplasia of the liver: a comprehensive pathologic study of 305 lesions and recognition of new histologic forms. Am J Surg Pathol 1999;23:1441-1454. https://doi.org/10.1097/00000478-199912000-00001
  58. Brunt EM, Flye MW. Infarction in focal nodular hyperplasia of the liver: a case report. Am J Clin Pathol 1991;95: 503-506. https://doi.org/10.1093/ajcp/95.4.503
  59. Lee MJ, Saini S, Hamm B, et al. Focal nodular hyperplasia of the liver: MR findings in 35 proved cases. AJR Am J Roentgenol 1991;156:317-320. https://doi.org/10.2214/ajr.156.2.1898806
  60. Ishak KG, Rabin L. Benign tumors of the liver. Med Clin North Am 1975;59:995-1013. https://doi.org/10.1016/S0025-7125(16)31998-8
  61. Quaia E. The real capabilities of contrast-enhanced ultrasound in the characterization of solid focal liver lesions. Eur Radiol 2011;21:457-462. https://doi.org/10.1007/s00330-010-2007-0
  62. Bartolozzi C, Lencioni R, Paolicchi A, Moretti M, Armillotta N, Pinto F. Differentiation of hepatocellular adenoma and focal nodular hyperplasia of the liver: comparison of power Doppler imaging and conventional color Doppler sonography. Eur Radiol 1997;7:1410-1415. https://doi.org/10.1007/s003300050308
  63. Carlson SK, Johnson CD, Bender CE, Welch TJ. CT of focal nodular hyperplasia of the liver. AJR Am J Roentgenol 2000;174:705-712. https://doi.org/10.2214/ajr.174.3.1740705
  64. Buetow PC, Pantongrag-Brown L, Buck JL, Ros PR, Goodman ZD. Focal nodular hyperplasia of the liver: radiologic-pathologic correlation. Radiographics 1996;16: 369-388. https://doi.org/10.1148/radiographics.16.2.8966294
  65. Irie H, Honda H, Kaneko K, et al. MR imaging of focal nodular hyperplasia of the liver: value of contrast-enhanced dynamic study. Radiat Med 1997;15:29-35.