The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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A Case of Sunitinib-Associated Thrombotic Thrombocytopenic Purpura

Sunitinib 투여로 유발된 혈전성 혈소판 감소성 자반증 1예

  • Kim, Eun Jin (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Choi, Yun Mi (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sin Won (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ha, Yeon Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Jae Lyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 김은진 (울산대학교 의과대학 서울아산병원 내과) ;
  • 최윤미 (울산대학교 의과대학 서울아산병원 내과) ;
  • 이신원 (울산대학교 의과대학 서울아산병원 내과) ;
  • 하연정 (울산대학교 의과대학 서울아산병원 내과) ;
  • 이재련 (울산대학교 의과대학 서울아산병원 내과)
  • Received : 2012.05.17
  • Accepted : 2012.08.06
  • Published : 2013.02.01
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Abstract

Thrombotic thrombocytopenic purpura and hemolytic uremic syndrome (TTP-HUS) is an acute condition with abnormalities of multiple organ systems. It is characterized by microangiopathic hemolytic anemia and thrombocytopenia. Several chemotherapeutic agents have been implicated in causing TTP-HUS. We report a case of TTP-HUS during treatment with sunitinib in a patient with metastatic renal cell carcinoma. A 53-year-old woman visited our hospital for fever and cough. She was diagnosed with sunitinib-induced TTP. Discontinuation of sunitinib and plasmapheresis improved her TTP. When she experienced disease progression after a prolonged period without treatment, sorafenib was tried, resulting in a partial response without recurrence of TTP-HUS.

혈전성 혈소판 감소성 자반증 및 용혈성 요독성 증후군은 다발성 장기 손상 및 미세혈관병증 용혈빈혈을 보이는 급성 질환으로 치료하지 않을 경우 환자의 생명을 위협하는 치명적인 질환이다. 최근 VEGFR-TKI가 혈전성 혈소판 감소성 자반증을 유발할 수 있다는 보고가 나오고 있어, 저자들은 전이성 콩팥세포암종 환자에서 수니티닙을 사용한 뒤, 혈전성 혈소판 감소성 자반증이 발생한 1예를 경험하였기에 이를 보고하는 바이다.

Keywords

References

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