DOI QR코드

DOI QR Code

약물과민성증후군과 유사한 임상양상을 보인 붉은사슴뿔버섯 중독 1예

A Case of Podostroma Cornu-Damae Intoxication Similar to Drug Hypersensitivity Syndrome

  • 양재남 (동국대학교 일산병원 알레르기내과) ;
  • 강지혁 (동국대학교 일산병원 알레르기내과) ;
  • 강윤성 (동국대학교 일산병원 알레르기내과) ;
  • 석순자 (농촌진흥청 국립농업과학원 농업미생물팀) ;
  • 김우경 (동국대학교 일산병원 알레르기내과)
  • Yang, Jae Nam (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine) ;
  • Kang, Ji Hyuk (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine) ;
  • Kang, Yun Seong (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine) ;
  • Seok, Soon Ja (Agricultural Microbiology Team, National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Woo Kyung (Department of Allergy Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine)
  • 투고 : 2012.05.22
  • 심사 : 2012.07.26
  • 발행 : 2013.08.01

초록

73세 남자 환자가 건강원에서 동충하초와 버섯으로 만든 술을 복용하고 하루 뒤에 발생한 얼굴 표피탈락과 구강점막염을 주소로 내원하였다. 약물과민성증후군 의심하에 치료하였으나, 환자 사망 이후에 버섯의 성분 분석 결과에서 독버섯으로 알려진 붉은사슴뿔버섯이 확인되었다. 저자들은 약물과민성증후군과 유사한 임상양상을 보인 붉은사슴뿔버섯 중독 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

The clinical aspects of intoxication can be similar to those of drug hypersensitivity syndrome, including desquamation, hematologic abnormalities, multiple organ failure, and even death. Many people consume mushrooms that they collect in the mountains, and consequently, the incidence of poisonous mushroom intoxication is increasing. Podostroma cornu-damae is a poisonous mushroom not well-known to the public that contains trichothecene, a deadly poison. It is difficult to differentiate P. cornu-damae from other edible mushrooms, especially young Ganoderma lucidum. Therefore, the general public should be aware of the dangers of indiscreet ingestion of mushrooms. When physicians treat patients presenting clinical symptoms similar to those of drug hypersensitivity reaction following the intake of mushrooms, poisonous mushroom intoxication must be taken into consideration. We report this case together with a literature review, as we experienced one P. cornu-damae intoxication case showing similar clinical aspects to drug hypersensitivity syndrome.

키워드

참고문헌

  1. McCormick SP, Stanley AM, Stover NA, Alexander NJ. Trichothecenes: from simple to complex mycotoxins. Toxin (Basel) 2011;3:802-814. https://doi.org/10.3390/toxins3070802
  2. Sullivan JR, Shear NH. The drug hypersensitivity syndrome: what is the pathogenesis? Arch Dermatol 2001;137:357-364.
  3. Kumari R, Timshina DK, Thappa DM. Drug hypersensitivity syndrome. Indian J Dermatol Venereol Leprol 2011;77: 7-15. https://doi.org/10.4103/0378-6323.74964
  4. Park JS, Park KM, Seok SJ, et al. Diversity of poisonous mushroom and investigation on their poisonous substance. Agricultural Science Institute, RDA 2008;533-540.
  5. Li Y, Wang Z, Beier RC, et al. T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods. J Agric Food Chem 2011;59:3441-3453. https://doi.org/10.1021/jf200767q
  6. Bin-Umer MA, McLaughlin JE, Basu D, McCormick S, Tumer NE. Trichothecene mycotoxins inhibit mitochondrial translation: implication for the mechanism of toxicity. Toxin (Basel) 2011;3:1484-1501. https://doi.org/10.3390/toxins3121484
  7. Suzuki M, Katoh Y, Kumagai H, et al. Successful treatment in a case of podostroma cornu-damae poisoning, a deadly poisonous mushroom. Chudoku Kenkyu 2002;15:177-182.
  8. Park SK, Kim CK, Hong DS. Three cases of reversible aplastic anemia by Genoderma tsugae. J Soonchunhyang Med Coll 2004;10:719-722.
  9. Choi GS, Shin YS, Kim JE, Ye YM, Park HS. Five cases of food allergy to vegetable worm (Cordyceps sinensis) showing cross-reactivity with silkworm pupae. Allergy 2010;65: 1196-1197.

피인용 문헌

  1. Four Cases of Successful Treatment after Podostroma Cornu-Damae Intoxication vol.23, pp.1, 2016, https://doi.org/10.1177/102490791602300107
  2. 변산반도 국립공원 고등균류의 자원이용적 특성 vol.31, pp.2, 2013, https://doi.org/10.13047/kjee.2017.31.2.230