The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Precursor B-Cell Acute Lymphoblastic Leukemia in Two Patients with a History of Cytotoxic Therapy

항암 치료 후 발생한 급성B림프모구백혈병 2예

  • Shin, Suk Pyo (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Song, Sang Hee (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Ko, Eun Jung (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Kim, Ji Su (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Park, Chi Young (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Oh, Doyeun (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Chong, So Young (Department of Internal Medicine, CHA Bundang Medical Center, CHA University)
  • 신석표 (차의과학대학교 분당차병원 내과학교실) ;
  • 송상희 (차의과학대학교 분당차병원 내과학교실) ;
  • 고은정 (차의과학대학교 분당차병원 내과학교실) ;
  • 김지수 (차의과학대학교 분당차병원 내과학교실) ;
  • 박치영 (차의과학대학교 분당차병원 내과학교실) ;
  • 오도연 (차의과학대학교 분당차병원 내과학교실) ;
  • 정소영 (차의과학대학교 분당차병원 내과학교실)
  • Received : 2012.10.18
  • Accepted : 2012.10.31
  • Published : 2013.07.01
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Abstract

Therapy-related myeloid neoplasms have been well characterized. However, precursor B-cell acute lymphoblastic leukemia in patients with prior malignancies is uncommon, and the effect of prior cytotoxic therapy on development of precursor B-cell acute lymphoblastic leukemia is controversial. Therapy-related precursor B-cell acute lymphoblastic leukemia has been reported occasionally. However, cytotoxic therapy-related precursor B-cell acute lymphoblastic leukemia has been reported in Korea only rarely. We herein describe two cases of therapy-related precursor B-cell acute lymphoblastic leukemia.

치료관련 골수성 백혈병은 잘 알려져 있으며 치료와의 연관성이 정립되어 있으나 치료관련 급성B림프모구백혈병은 드물고 이전의 악성 종양의 항암 치료와 방사선 치료가 급성B림프모구백혈병 발생에 영향을 미치는지는 아직 논란이 많다. 최근에 세포독성 치료와 연관된 급성B림프모구백혈병의 보고가 있으며 국내에서도 드물게 보고되고 있다. 이에 저자들은 과거 세포독성 치료를 한 뒤 급성B림프모구백혈병이 발병한 증례 2예를 경험하였기에 보고하는 바이다.

Keywords

References

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