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Two Cases of Supraclavicular Lymph Node Metastasis in Pancreatic Adenocarcinoma

췌장암에서의 좌측 쇄골상부 림프절 전이 2예

  • Min, Hyun Jun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Lee, Byoung Moo (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Dae Yong (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Ahn, Pyoung (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Park, Sang Hyun (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Han, Jeung Wan (Department of Internal Medicine, Hangang Sacred Heart Hospital, Hallym University College of Medicine) ;
  • Kim, Jin Bong (Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine)
  • 민현준 (한림대학교 의과대학 춘천성심병원) ;
  • 이병무 (한림대학교 의과대학 춘천성심병원) ;
  • 김대용 (한림대학교 의과대학 춘천성심병원) ;
  • 안평 (한림대학교 의과대학 춘천성심병원) ;
  • 박상현 (한림대학교 의과대학 춘천성심병원) ;
  • 한정완 (한림대학교 의과대학 한강성심병원 내과) ;
  • 김진봉 (한림대학교 의과대학 춘천성심병원)
  • Received : 2012.04.24
  • Accepted : 2012.09.27
  • Published : 2013.07.01

Abstract

The supraclavicular lymph node (SCN) is frequently involved in lymphoma and metastatic malignancies of the breast and lung, but is extremely rarely involved in pancreatic cancer. Only 10 such cases have been reported in the medical literature worldwide. We herein report an additional two cases. An 83-year-old male patient had a 7.6 ${\times}$ 5 cm pancreatic tumor from the pancreatic head to tail, and a 71-year-old male patient had a 2.8 ${\times}$ 1.9 cm pancreatic body tumor. PET-CT revealed SCN metastasis, and subsequent excisional biopsy confirmed metastatic adenocarcinoma. With the more popular use of PET-CT in patients with pancreatic cancer, the number of cases of metastasis to the SCN is expected to increase. This suggests that lymphatic spread is the main metastatic route in pancreatic cancer. Further large-scale studies along with increased numbers of case reports are needed to determine whether lymphatic spread is the main metastatic route in pancreatic cancer.

췌장암은 악성종양의 5% 이하를 차지하는 암으로, 이차적인 쇄골상부 림프절 전이의 빈도수는 알려진 바가 없으며 문헌상 보고된 증례는 전 세계적으로 10예에 불과하다. 저자들은 췌장 두부에서 꼬리에까지 약 7.6 ${\times}$ 5 cm의 췌장암으로 진단된 83세 남자와 2.8 ${\times}$ 1.9 cm의 췌장 체부암을 보인 71세 남자에서 PET CT로 좌측 쇄골상부 림프절 전이가 확인되었고 조직 생검 절제로 전이성 선암을 확인하였다. 췌장암의 림프절 전이는 이미 잘 알려져 있으나 주로 복부 림프절 전이이고 쇄골상부 림프절 전이는 그 보고 예가 극히 드물기에 문헌고찰과 더불어 보고하는 바이다. 향후 PET CT 등의 영상진단기술의 발달과 더불어 보고 예가 증가한다면 췌장암의 주된 전이경로가 임파성 전이일 수도 있음을 시사할 수도 있겠으나 이를 위해서는 적극적인 증례보고와 더불어 대규모의 후향적 연구가 필요하다.

Keywords

References

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