The Korean Journal of Medicine

  • 제84권6호
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  • Pages.855-859
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  • 2013
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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급성골수성 백혈병으로 조혈모세포 이식 후 발생한 호지킨림프종 2예

Two Cases of Hodgkin's Lymphoma after Allogeneic Hematopoietic Cell Transplantation

  • 진선미 (차의과학대학교 내과학교실) ;
  • 김경호 (차의과학대학교 내과학교실) ;
  • 김건우 (차의과학대학교 내과학교실) ;
  • 문지혜 (차의과학대학교 내과학교실) ;
  • 김광일 (차의과학대학교 병리학교실) ;
  • 오도연 (차의과학대학교 내과학교실) ;
  • 정소영 (차의과학대학교 내과학교실)
  • Jin, Sun Mi (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Kim, Kyung Ho (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Kim, Gun Woo (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Moon, Jie Hye (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Kim, Gwang Il (Department of Pathology, CHA Bundang Medical Center, CHA University) ;
  • Oh, Doyeun (Department of Internal Medicine, CHA Bundang Medical Center, CHA University) ;
  • Chong, So Young (Department of Internal Medicine, CHA Bundang Medical Center, CHA University)
  • 투고 : 2012.09.07
  • 심사 : 2012.10.17
  • 발행 : 2013.06.01
⟨ 이전 논문 다음 논문 ⟩

초록

조혈모세포 이식이 널리 사용되면서 이식 후 발생하는 림프증식성질환은 후기 생존율에 영향을 끼치는 주요한 합병증의 하나로 그 중요성이 대두되고 있다. 이식 후 림프증식성질환 중 호지킨림프종은 드물다고 알려져 있으나 저자들이 2예를 경험하였기에 보고하는 바이다. 두 증례 모두 급성골수성백혈병으로 동종조혈모세포 이식을 시행하였고 각각 이식 후 45개월, 36개월 뒤에 혼합세포형의 호지킨림프종이 림프절의 조직 검사로 진단되었다. 한 증례는 ABVD 요법으로 항암화학치료 중이며 다른 한 증례는 진단 후 보존적 치료 중에 사망하였다.

Hematopoietic cell transplantation recipients have a high risk of subsequent malignant neoplasms. Among post-transplantation lymphoproliferative disorders (PTLDs) after hematopoietic cell transplantation, Hodgkin's lymphoma is rare and distinct from the majority of other PTLDs because of its later onset and relatively good prognosis. It is known to be associated with exposure to the Epstein-Barr virus, and the mixed cellularity subtype is the most common. We herein describe two cases of Hodgkin's lymphoma that developed after allogeneic hematopoietic cell transplantation.

키워드

참고문헌

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  7. Lee SM, Kim KH, Kang MJ, Choi MY, Lee WS, Joo YD. Hodgkin's lymphoma-like posttransplantation lymphoproliferative disorder after allogeneic hematopoietic stem cell transplantation. Korean J Hematol 2009;44:278-283. https://doi.org/10.5045/kjh.2009.44.4.278
  8. Kim MJ, Kim I, Bae HM, et al. Hematopoietic stem cell transplantation after posttransplant lymphoproliferative disorder. J Korean Med Sci 2010;25:781-784. https://doi.org/10.3346/jkms.2010.25.5.781
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  10. Rowlings PA, Curtis RE, Passweg JR, et al. Increased incidence of Hodgkin's disease after allogeneic bone marrow transplantation. J Clin Oncol 1999;17:3122-3127. https://doi.org/10.1200/JCO.1999.17.10.3122

피인용 문헌

  1. Hodgkin's Lymphoma after Autologous Hematopoietic Stem Cell Transplantation for Angioimmunoblastic T-cell Lymphoma vol.86, pp.6, 2013, https://doi.org/10.3904/kjm.2014.86.6.774
  2. Fatal PTLD Accompanied by Rapid Lymphocyte Proliferation in the Early Phase of Allogeneic HSCT vol.89, pp.2, 2015, https://doi.org/10.3904/kjm.2015.89.2.243