DOI QR코드

DOI QR Code

Extramedullary Solitary Plasmacytoma of the Lymph Nodes

림프절에 발생한 골수외 고립 형질세포종

  • Kim, Min (Department of Internal Medicine, Inje University Ilsan Paik Hospital) ;
  • Lee, Hyuk (Department of Internal Medicine, Inje University Ilsan Paik Hospital) ;
  • Heo, Tae Gil (Department of General Surgery, Inje University Ilsan Paik Hospital) ;
  • Chang, Sunhee (Department of Pathology, Inje University Ilsan Paik Hospital) ;
  • Yun, Hyung Geun (Department of Radiation Oncology, Dong Guk University International Hospital) ;
  • Yoon, Seong Min (Department of Internal Medicine, Inje University Ilsan Paik Hospital) ;
  • Lee, Hye Ran (Department of Internal Medicine, Inje University Ilsan Paik Hospital)
  • 김민 (인제대학교 일산백병원 내과학교실) ;
  • 이혁 (인제대학교 일산백병원 내과학교실) ;
  • 허태길 (인제대학교 일산백병원 외과학교실) ;
  • 장선희 (인제대학교 일산백병원 병리학교실) ;
  • 윤형근 (동국대학교 일산병원 방사선종양학교실) ;
  • 윤성민 (인제대학교 일산백병원 내과학교실) ;
  • 이혜란 (인제대학교 일산백병원 내과학교실)
  • Received : 2008.10.13
  • Accepted : 2009.07.24
  • Published : 2013.05.01

Abstract

Extramedullary plasmacytomas are uncommon malignant neoplasms that can occur in any organ. They arise most frequently from the upper aerodigestive tract. Lymph nodes are exceedingly rare sites of extramedullary plasmacytomas. Most extramedullary plasmacytomas of the lymph node arise in the cervical lymph nodes. Here, we report a case of an extramedullary plasmacytoma of the lymph node arising from a cervical lymph node. A 43-year-old male patient was admitted to our hospital and presented with a non-tender mass on the left side of his neck, which had been growing slowly for 1 month. The mass was excised. The pathology showed diffuse infiltration of immature plasma cells that were encapsulated by a layer of lymphoid cells, indicating an extramedullary plasmacytoma. He was treated with local radiation of the left cervical area. As of March 2009, he is doing well and shows no further evidence of the disease.

Keywords

References

  1. Addis BJ, Isaacson P, Billings JA. Plasmacytoma of lymph nodes. Cancer 1980;46:340-346. https://doi.org/10.1002/1097-0142(19800715)46:2<340::AID-CNCR2820460222>3.0.CO;2-F
  2. Jyothirmayi R, Gangadharan VP, Nair MK, Rajan B. Radiotherapy in the treatment of solitary plasmacytoma. Br J Radiol 1997;70:511-516. https://doi.org/10.1259/bjr.70.833.9227234
  3. Lin BT, Weiss LM. Primary plasmacytoma of lymph nodes. Hum Pathol 1997;28:1083-1090. https://doi.org/10.1016/S0046-8177(97)90063-0
  4. Menke DM, Horny HP, Griesser H, et al. Primary lymph node plasmacytomas (plasmacytic lymphomas). Am J Clin Pathol 2001;115:119-126. https://doi.org/10.1309/L2GR-PCFM-G4A3-GHDW
  5. Soutar R, Lucraft H, Jackson G, et al. Guidelines on the diagnosis and management of solitary plasmacytoma of bone and solitary extramedullary plasmacytoma. Clin Oncol (R Coll Radiol) 2004;16:405-413. https://doi.org/10.1016/j.clon.2004.02.007
  6. Tsang RW, Gospodarowicz MK, Pintilie M, et al. Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome. Int J Radiat Oncol Biol Phys 2001;50: 113-120. https://doi.org/10.1016/S0360-3016(00)01572-8
  7. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore) 1976;55:217-238. https://doi.org/10.1097/00005792-197605000-00002
  8. Woodruff RK, Whittle JM, Malpas JS. Solitary plasmacytoma: I. extramedullary soft tissue plasmacytoma. Cancer 1979;43:2340-2343. https://doi.org/10.1002/1097-0142(197906)43:6<2340::AID-CNCR2820430625>3.0.CO;2-M
  9. Lim YH, Park SK, Oh HS, et al. A case of primary plasmacytoma of lymph nodes. Korean J Intern Med 2005;20: 183-186. https://doi.org/10.3904/kjim.2005.20.2.183
  10. Corwin J, Lindberg RD. Solitary plasmacytoma of bone vs. extramedullary plasmacytoma and their relationship to multiple myeloma. Cancer 1979;43:1007-1013. https://doi.org/10.1002/1097-0142(197903)43:3<1007::AID-CNCR2820430333>3.0.CO;2-4
  11. Holland J, Trenkner DA, Wasserman TH, Fineberg B. Plasmacytoma: treatment results and conversion to myeloma. Cancer 1992;69:1513-1517. https://doi.org/10.1002/1097-0142(19920315)69:6<1513::AID-CNCR2820690633>3.0.CO;2-X
  12. Meis JM, Butler JJ, Osborne BM, Ordonez NG. Solitary plasmacytomas of bone and extramedullary plasmacytomas: a clinicopathologic and immunohistochemical study. Cancer 1987;59:1475-1485. https://doi.org/10.1002/1097-0142(19870415)59:8<1475::AID-CNCR2820590814>3.0.CO;2-2
  13. Andersen PE. Extramedullary plasmocytomas. Acta radiol 1949;32:365-374. https://doi.org/10.3109/00016924909140000
  14. Frizzera G. Castleman's disease and related disorders. Semin Diagn Pathol 1988;5:346-364.

Cited by

  1. Unusual course of generalized lymph node primary plasmacytoma in a patient with Sjögren’s syndrome: a case report vol.11, pp.1, 2017, https://doi.org/10.1186/s13256-017-1266-7
  2. Clinicopathological spectrum of solitary Plasmacytoma: a single center experience from coastal India vol.19, pp.1, 2013, https://doi.org/10.1186/s12885-019-5976-7