DOI QR코드

DOI QR Code

A Case of Community-Acquired Methicillin-Resistant Staphylococcus aureus Pneumonia

지역사회획득 메티실린 내성 황색포도구균 폐렴 1예

  • Lee, Yong Hoon (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Cha, Seung-Ick (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Lee, So Yeon (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Choi, Sun Ha (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Oh, Serim (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Seo, Hyewon (Department of Internal Medicine, Kyungpook National University School of Medicine) ;
  • Kim, Jungmin (Department of Microbiology, Kyungpook National University School of Medicine)
  • 이용훈 (경북대학교 의학전문대학원 내과학교실) ;
  • 차승익 (경북대학교 의학전문대학원 내과학교실) ;
  • 이소연 (경북대학교 의학전문대학원 내과학교실) ;
  • 최선하 (경북대학교 의학전문대학원 내과학교실) ;
  • 오세림 (경북대학교 의학전문대학원 내과학교실) ;
  • 서혜원 (경북대학교 의학전문대학원 내과학교실) ;
  • 김정민 (경북대학교 의학전문대학원 미생물학교실)
  • Received : 2012.09.22
  • Accepted : 2012.11.26
  • Published : 2013.05.01

Abstract

Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) has received considerable attention in recent years as the cause of infections in individuals in the community who do not have traditional risk factors for MRSA infection, such as hospitalization or contact with healthcare services. CA-MRSA strains have different molecular and antimicrobial susceptibilities, as compared to hospital-associated MRSA. Although CA-MRSA strains are primarily associated with skin and soft tissue infections, they can cause more invasive infections, such as severe community-acquired pneumonia. Reports on CA-MRSA pneumonia in Korea are sparse. Therefore, we report a case of CA-MRSA pneumonia with molecular typing of the MRSA isolate.

입원력이나 뚜렷한 병원접촉이 없던 환자에서 발생하는 지역사회획득 메티실린 내성 황색포도구균(CA-MRSA) 감염의 중요성이 최근 대두되고 있다. CA-MRSA는 병원획득 MRSA와 다른 유전형과 항생제 감수성을 보인다. CA-MRSA는 주로 피부 및 연조직 감염의 형태로 나타나지만 점차 폐렴과 같은 중증 감염의 사례도 증가하고 있다. 그러나 국내에서 CA-MRSA 폐렴은 아직 매우 드문 실정이다. 이에 저자들은 최근 유전형을 확인한 CA-MRSA 폐렴 1예를 경험하였기에 문헌고찰과 더불어 보고하는 바이다.

Keywords

References

  1. Yi J, Kim EC. Microbiological characteristics of methicillinresistant Staphylococcus aureus. Korean J Clin Microbiol 2010;13:1-6. https://doi.org/10.5145/KJCM.2010.13.1.1
  2. Kim HB. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA). Korean J Intern Med 2007;72: 120-130.
  3. Wallin TR, Hern HG, Frazee BW. Community-associated methicillin-resistant Staphylococcus aureus. Emerg Med Clin North Am 2008;26:431-455. https://doi.org/10.1016/j.emc.2008.01.010
  4. Oliveira DC, de Lencastre H. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 2002;46:2155-2161. https://doi.org/10.1128/AAC.46.7.2155-2161.2002
  5. Enright MC, Day NP, Davies CE, Peacock SJ, Spratt BG. Multilocus sequence typing for characterization of methicillinresistant and methicillin-susceptible clones of Staphylococcus aureus. J Clin Microbiol 2000;38:1008-1015.
  6. Koreen L, Ramaswamy SV, Graviss EA, Naidich S, Musser JM, Kreiswirth BN. Spa typing method for discriminating among Staphylococcus aureus isolates: implications for use of a single marker to detect genetic micro- and macrovariation. J Clin Microbiol 2004;42:792-799. https://doi.org/10.1128/JCM.42.2.792-799.2004
  7. Kim ES, Song JS, Lee HJ, et al. A survey of communityassociated methicillin-resistant Staphylococcus aureus in Korea. J Antimicrob Chemother 2007;60:1108-1114. https://doi.org/10.1093/jac/dkm309
  8. Sohn KM, Chung DR, Baek JY, et al. Post-influenza pneumonia caused by the USA300 community-associated methicillin-resistant Staphylococcus aureus in Korea. J Korean Med Sci 2012;27:313-316. https://doi.org/10.3346/jkms.2012.27.3.313
  9. Hidron AI, Low CE, Honig EG, Blumberg HM. Emergence of community-acquired meticillin-resistant Staphylococcus aureus strain USA300 as a cause of necrotising communityonset pneumonia. Lancet Infect Dis 2009;9:384-392. https://doi.org/10.1016/S1473-3099(09)70133-1
  10. Bae IG, Kim JS, Kim S, Heo ST, Chang C, Lee EY. Genetic correlation of community-associated methicillin-resistant Staphylococcus aureus strains from carriers and from patients with clinical infection in one region of Korea. J Korean Med Sci 2010;25:197-202. https://doi.org/10.3346/jkms.2010.25.2.197