The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지
DOI QR코드

DOI QR Code

Colonic Langerhans Cell Histiocytosis Presenting as an Isolated Polyp

대장 용종에 국한되어 발생한 랑게르한스 세포 조직구증 1예

  • Seo, Hyun Woong (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Han, Koon Hee (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Kim, Sunghun (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Hong, Man Yong (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Yun, Jung Ho (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Eom, Dae Woon (Department of Pathology, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Cheon, Gab Jin (Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine)
  • 서현웅 (울산대학교 의과대학 강릉아산병원 내과) ;
  • 한군희 (울산대학교 의과대학 강릉아산병원 내과) ;
  • 김성훈 (울산대학교 의과대학 강릉아산병원 내과) ;
  • 홍만용 (울산대학교 의과대학 강릉아산병원 내과) ;
  • 윤정호 (울산대학교 의과대학 강릉아산병원 내과) ;
  • 엄대운 (울산대학교 의과대학 강릉아산병원 병리과) ;
  • 천갑진 (울산대학교 의과대학 강릉아산병원 내과)
  • Received : 2012.07.31
  • Accepted : 2012.10.02
  • Published : 2013.05.01
⟨ Previous Next ⟩

Abstract

A 56-year-old male underwent a screening colonoscopy. An 8-mm sessile polyp was removed from the descending colon using snare polypectomy. Histology showed Langerhans cells and eosinophil infiltration of the submucosa. Immunohistochemical staining was positive for S-100 protein and CD1a antigen, which confirmed the diagnosis of Langerhans-cell histiocytosis. On further workup, there was no evidence of involvement of any other organs. Here, we report a very rare case of colonic Langerhans-cell histiocytosis presenting as an isolated polyp.

저자들은 무증상의 환자에서 시행한 검진 대장내시경에서 무경성 용종을 용종 절제술을 통해 제거하고 이에 대한 조직 검사에서 랑게르한스 세포 조직구의 침윤이 관찰되고 면역 화학 염색에서 S-100 protein과 CD1a 항원 양성 소견을 보여 랑게르한스 세포 조직구증을 진단하였으며 타장기 침범 소견이 없어 경과관찰 중인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Keywords

References

  1. Abla O, Egeler RM, Weitzman S. Langerhans cell histiocytosis: current concepts and treatments. Cancer Treat Rev 2010;36:354-359. https://doi.org/10.1016/j.ctrv.2010.02.012
  2. Ng-Cheng-Hin B, O'Hanlon-Brown C, Alifrangis C, Waxman J. Langerhans cell histiocytosis: old disease new treatment. QJM 2011;104:89-96. https://doi.org/10.1093/qjmed/hcq206
  3. Sharma S, Gupta M. A colonic polyp due to Langerhans cell histiocytosis: a lesion not to be confused with metastatic malignant melanoma. Histopathology 2006;49:438-439. https://doi.org/10.1111/j.1365-2559.2006.02463.x
  4. Kibria R, Gibbs PM, Novick DM. Adult Langerhans cell histiocytosis: a rare cause of colon polyp. Endoscopy 2009; 41(Suppl 2):E160-161. https://doi.org/10.1055/s-0029-1214689
  5. Shankar U, Prasad M, Chaurasia OP. A rare case of langerhans cell histiocytosis of the gastrointestinal tract. World J Gastroenterol 2012;18:1410-1413. https://doi.org/10.3748/wjg.v18.i12.1410
  6. Lee SJ, Kim KJ, Yoon SM, et al. A case of Langerhans cell histiocytosis that involved the colon. Korean J Gastrointest Endosc 2009;38:166-170.
  7. Grois N, Pötschger U, Prosch H, et al. Risk factors for diabetes insipidus in langerhans cell histiocytosis. Pediatr Blood Cancer 2006;46:228-233. https://doi.org/10.1002/pbc.20425
  8. Howarth DM, Gilchrist GS, Mullan BP, Wiseman GA, Edmonson JH, Schomberg PJ. Langerhans cell histiocytosis: diagnosis, natural history, management, and outcome. Cancer 1999;85:2278-2290. https://doi.org/10.1002/(SICI)1097-0142(19990515)85:10<2278::AID-CNCR25>3.0.CO;2-U
  9. Hait E, Liang M, Degar B, Glickman J, Fox VL. Gastrointestinal tract involvement in Langerhans cell histiocytosis: case report and literature review. Pediatrics 2006;118: e1593-1599. https://doi.org/10.1542/peds.2006-0708
  10. Gadner H, Grois N, Arico M, et al. A randomized trnal of treatment for multisystem Langerhans' cell histiocytosis. J Pediatr 2001;138:728-734. Erratum in: J Pediatr 2001;139: https://doi.org/10.1067/mpd.2001.111331