DOI QR코드

DOI QR Code

Ethanol Lavage Therapy to Prevent Recurrent Pancreatitis in a Patient with Pancreatic Mucinous Neoplasm

에탄올 세척술로 췌장 점액종에 의한 반복적 췌장염 발생을 예방 치료한 1예

  • Kim, Jung Hee (Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Hyo Jin (Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jang, Eun-Young (Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Se-ok (Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Choi, Kyu (Departments of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Kwang Hyuck (Division of Gastroenterology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 김정희 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 김효진 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 장은영 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 이세옥 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 최규 (성균관대학교 의과대학 삼성서울병원 내과) ;
  • 이광혁 (성균관대학교 의과대학 삼성서울병원 소화기내과)
  • Received : 2012.09.05
  • Accepted : 2012.10.16
  • Published : 2013.11.01

Abstract

An 88-year-old woman diagnosed with recurrent pancreatitis and pancreatic cyst at a local clinic was admitted for upper abdominal pain. The pain was aggravated after a meal, and the patient had lost 3 kg over the past 6 months. MRCP examination revealed a 68 mm-sized septated pancreatic cyst compressing the main pancreatic duct. EUS-FNA to differentiate the cystic component retrieved a high viscosity fluid. A diagnosis of mucin-producing pancreatic cystic neoplasm was made. The patient refused surgical treatment, and alternative treatments, including methods to decompress the pancreatic cyst, were performed. The patient was treated with aspiration of cystic fluid, observation with diet control, and 99% ethanol lavage to ablate the pancreatic cyst. The treatment of 99% ethanol lavage provided the longest symptom-free period, ranging from 7 to 18 months without complications. The authors report that repeated ethanol lavage of a pancreatic cyst causing recurrent pancreatitis can be an effective treatment option for patients who are poor surgical candidates.

췌장 낭종에서 낭종으로 인한 췌장염 발생 및 덩이 효과로 증상이 있는 경우 수술적 절제가 필요하나 환자의 연령, 기저 질환 고려하여 이환율, 사망률이 상대적으로 높아질 경우 초음파 내시경을 통한 반복적인 에탄올 세척술이 큰 합병증의 발생 없이 췌장염 발생 및 복부 증상 조절에 도움이 되었음을 보고하는 바이다.

Keywords

References

  1. Lee HJ, Kim MJ, Choi JY, Hong HS, Kim KA. Relative accuracy of CT and MRI in the differentiation of benign from malignant pancreatic cystic lesions. Clin Radiol 2011; 66:315-321. https://doi.org/10.1016/j.crad.2010.06.019
  2. Cho HW, Choi JY, Kim MJ, et al. Pancreatic tumors: emphasis on CT findings and pathologic classification. Korean J Radiol 2011;12:731-739. https://doi.org/10.3348/kjr.2011.12.6.731
  3. Khalid A, Brugge W. ACG practice guidelines for the diagnosis and management of neoplastic pancreatic cysts. Am J Gastroenterol 2007;102:2339-2349. https://doi.org/10.1111/j.1572-0241.2007.01516.x
  4. Balcom JH 4th, Rattner DW, Warshaw AL, Chang Y, Fernandez-del Castillo C. Ten-year experience with 733 pancreatic resections: changing indications, older patients, and decreasing length of hospitalization. Arch Surg 2001; 136:391-398. https://doi.org/10.1001/archsurg.136.4.391
  5. Kim YT. Medical management of intraductal papillary mucinous neoplasm. Korean J Gastroenterol 2008;52: 214-219.
  6. Brugge WR, Lewandrowski K, Lee-Lewandrowski E, et al. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology 2004; 126:1330-1336. https://doi.org/10.1053/j.gastro.2004.02.013
  7. Oh HC, Seo DW, Kim SC, et al. Septated cystic tumors of the pancreas: is it possible to treat them by endoscopic ultrasonography-guided intervention? Scand J Gastroenterol 2009;44:242-247. https://doi.org/10.1080/00365520802495537
  8. Gan SI, Thompson CC, Lauwers GY, Bounds BC, Brugge WR. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc 2005;61:746-752. https://doi.org/10.1016/S0016-5107(05)00320-2
  9. Oh HC, Seo DW, Song TJ, et al. Endoscopic ultrasonography- guided ethanol lavage with paclitaxel injection treats patients with pancreatic cysts. Gastroenterology 2011; 140:172-179. https://doi.org/10.1053/j.gastro.2010.10.001
  10. DeWitt J, McGreevy K, Schmidt CM, Brugge WR. EUSguided ethanol versus saline solution lavage for pancreatic cysts: a randomized, double-blind study. Gastrointest Endosc 2009;70:710-723. https://doi.org/10.1016/j.gie.2009.03.1173