The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Diffuse Alveolar Hemorrhage after Adalimumab Treatment of Rheumatoid Arthritis

류마티스 관절염 환자에서 종양괴사인자 억제제 사용 중 발생한 미만성 폐포 출혈 1예

  • Kim, Hye Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Chough, Hong-Sung (Department of Internal Medicine, Chosun University College of Medicine) ;
  • Kim, Yun Sung (Department of Internal Medicine, Chosun University College of Medicine) ;
  • Kim, Hyun-Sook (Department of Internal Medicine, Soonchunhyang University College of Medicine)
  • 김혜진 (순천향대학교 의과대학 내과학교실) ;
  • 조홍성 (조선대학교 의과대학 내과학교실) ;
  • 김윤성 (조선대학교 의과대학 내과학교실) ;
  • 김현숙 (순천향대학교 의과대학 내과학교실)
  • Received : 2013.04.02
  • Accepted : 2013.05.15
  • Published : 2013.10.01
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Abstract

Diffuse alveolar hemorrhage (DAH) is a life-threatening condition involving hemorrhage originating in the pulmonary microvasculature. The clinical syndrome is characterized by hemoptysis, hypoxemic respiratory failure, low-grade fever, and diffuse pulmonary infiltrates. The majority of cases of DAH are caused by pulmonary renal syndromes, connective tissue disorders, and drugs. Here, we present a case of DAH associated with adalimumab treatment in a patient with rheumatoid arthritis.

RA 치료로 쓰이는 종양괴사인자 억제제의 안정성 및 효용성은 이미 입증되었으나 임상에서 약제 사용과 관련한 심각한 부작용을 염두에 두어야 한다. 저자들은 종양괴사인자 억제제, adalimumab 사용과 관련한 DAH를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다.

Keywords

References

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