Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The Protective and Recovery Effects of Peucedanum Japonicum Thunberg for Vascular Dementia

식방풍의 혈관성 치매에 대한 예방과 치료효과 검증

  • Kim, Ka-Na (Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University) ;
  • Choi, Min-Ji (Department of Neuropsychiatry, Oriental Medicine Center, Kyung-Hee University) ;
  • Lee, Younghyurk (Department of Neuropsychiatry, Oriental Medicine Center, Kyung-Hee University) ;
  • Cho, Seung-Hun (Department of Neuropsychiatry, College of Korean Medicine, Kyung-Hee University)
  • 김가나 (경희대학교 한의과대학 신경정신과) ;
  • 최민지 (경희대학교 한방병원 신경정신과) ;
  • 이영혁 (경희대학교 한방병원 신경정신과) ;
  • 조성훈 (경희대학교 한의과대학 신경정신과)
  • Received : 2013.03.01
  • Accepted : 2013.03.20
  • Published : 2013.03.30
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Abstract

Objectives : During several thousand years, Peucedanum Japonicum Thunberg has been considered as a vegetable side dish in Korea. There is folk knowledge that Peucedanum Japonicum Thunberg prevents vascular disease such as stroke. To identify the effects Peucedanum Japonicum Thunberg, we made up its extract and named it as KH020. Then, we employed common carotid artery ligation (CCAl) surgery for vascular dementia model (VDM), and two types doses of per os (per oral: p.o) treatment. Methods : To confirm prevention and recovery effects for vascular dementia, we treated two doses (100, 400 mg/kg) KH020 in male C57BL/6 mouse during 7 days. After treatment, animals were CCAl operated, and given time to recover. Then, animal were tested in a Y-maze and passive avoidance test. Results : Y-maze results demonstrated that cognition and memory performance were decreased in the VDM group, compared to the sham group. KH020 treatment abolished these effects significantly. The results from the passive avoidance test showed the same phenomenon, but it was not statically significant. Conclusions : Therefore, KH020 prevents the onset of vascular dementia. In future studies, we will evaluate KH020 in regard to alzheimer dementia.

Keywords

References

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