Radiation Oncology Journal

  • 제31권1호
  • /
  • Pages.1-11
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  • 2013
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  • 2234-1900(pISSN)
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  • 2234-3156(eISSN)
대한방사선종양학회 (The Korean Society for Radiation Oncology)
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Comparison of survival rates between patients treated with conventional radiotherapy and helical tomotherapy for head and neck cancer

  • Kong, Moonkyoo (Department of Radiation Oncology, Kyung Hee University School of Medicine) ;
  • Hong, Seong Eon (Department of Radiation Oncology, Kyung Hee University School of Medicine) ;
  • Choi, Jinhyun (Department of Radiation Oncology, Kyung Hee University School of Medicine) ;
  • Kim, Youngkyong (Department of Radiation Oncology, Kyung Hee University School of Medicine)
  • 투고 : 2012.10.12
  • 심사 : 2012.12.14
  • 발행 : 2013.03.31
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초록

Purpose: Compared to conventional radiotherapy (RT), intensity-modulated radiotherapy (IMRT) significantly reduces the rate of treatment-induced late toxicities in head and neck cancer. However, a clear survival benefit of IMRT over conventional RT has not yet been shown. This study is among the first comparative study to compare the survival rates between conventional RT and helical tomotherapy in head and neck cancer. Materials and Methods: From January 2008 to November 2011, 37 patients received conventional RT and 30 patients received helical tomotherapy for management of head and neck cancer. We retrospectively compared the survival rates between patients treated with conventional RT and helical tomotherapy, and analyzed the prognostic factors for survival. Results: The 1- and 2-year locoregional recurrence-free survival rates were 61.2% and 58.1% for the conventional RT group, 89.3% and 80.3% for the helical tomotherapy group, respectively. The locoregional recurrence-free survival rates of the helical tomotherapy group were significantly higher than conventional RT group (p = 0.029). There were no significant differences in the overall and distant metastasis-free survival between the two groups. RT technique, tumor stage, and RT duration were significant prognostic factors for locoregional recurrence-free survival. Conclusion: This study showed the locoregional recurrence-free survival benefits of helical tomotherapy in the treatment of head and neck cancers.

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참고문헌

  1. Clark CH, Bidmead AM, Mubata CD, Harrington KJ, Nutting CM. Intensity-modulated radiotherapy improves target coverage, spinal cord sparing and allows dose escalation in patients with locally advanced cancer of the larynx. Radiother Oncol 2004;70:189-98. https://doi.org/10.1016/j.radonc.2003.10.012
  2. Wu Q, Manning M, Schmidt-Ullrich R, Mohan R. The potential for sparing of parotids and escalation of biologically effective dose with intensity-modulated radiation treatments of head and neck cancers: a treatment design study. Int J Radiat Oncol Biol Phys 2000;46:195-205. https://doi.org/10.1016/S0360-3016(99)00304-1
  3. Orlandi E, Palazzi M, Pignoli E, Fallai C, Giostra A, Olmi P. Radiobiological basis and clinical results of the simultaneous integrated boost (SIB) in intensity modulated radiotherapy (IMRT) for head and neck cancer: a review. Crit Rev Oncol Hematol 2010;73:111-25. https://doi.org/10.1016/j.critrevonc.2009.03.003
  4. Traynor AM, Richards GM, Hartig GK, et al. Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: the University of Wisconsin experience. Head Neck 2010;32:599-606.
  5. Bhide SA, Ahmed M, Newbold K, Harrington KJ, Nutting CM. The role of intensity modulated radiotherapy in advanced oral cavity carcinoma. J Cancer Res Ther 2012;8 Suppl 1:S67-71.
  6. Chao KS, Low DA, Perez CA, Purdy JA. Intensity-modulated radiation therapy in head and neck cancers: the Mallinckrodt experience. Int J Cancer 2000;90:92-103. https://doi.org/10.1002/(SICI)1097-0215(20000420)90:2<92::AID-IJC5>3.0.CO;2-9
  7. Chau RM, Teo PM, Kam MK, Leung SF, Cheung KY, Chan AT. Dosimetric comparison between 2-dimensional radiation therapy and intensity modulated radiation therapy in treatment of advanced T-stage nasopharyngeal carcinoma: to treat less or more in the planning organ-at-risk volume of the brainstem and spinal cord. Med Dosim 2007;32:263-70. https://doi.org/10.1016/j.meddos.2007.02.006
  8. Chao KS, Deasy JO, Markman J, et al. A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: initial results. Int J Radiat Oncol Biol Phys 2001;49:907-16. https://doi.org/10.1016/S0360-3016(00)01441-3
  9. Rades D, Fehlauer F, Wroblesky J, Albers D, Schild SE, Schmidt R. Prognostic factors in head-and-neck cancer patients treated with surgery followed by intensity-modulated radiotherapy (IMRT), 3D-conformal radiotherapy, or conventional radiotherapy. Oral Oncol 2007;43:535-43. https://doi.org/10.1016/j.oraloncology.2006.05.006
  10. Nutting CM, Morden JP, Harrington KJ, et al. Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): a phase 3 multicentre randomised controlled trial. Lancet Oncol 2011;12:127-36. https://doi.org/10.1016/S1470-2045(10)70290-4
  11. Vergeer MR, Doornaert PA, Rietveld DH, Leemans CR, Slotman BJ, Langendijk JA. Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health-related quality of life: results of a nonrandomized prospective study using a standardized follow-up program. Int J Radiat Oncol Biol Phys 2009;74:1-8. https://doi.org/10.1016/j.ijrobp.2008.07.059
  12. Yao M, Karnell LH, Funk GF, Lu H, Dornfeld K, Buatti JM. Health-related quality-of-life outcomes following IMRT versus conventional radiotherapy for oropharyngeal squamous cell carcinoma. Int J Radiat Oncol Biol Phys 2007;69:1354-60. https://doi.org/10.1016/j.ijrobp.2007.05.003
  13. Fowler JF. The linear-quadratic formula and progress in fractionated radiotherapy. Br J Radiol 1989;62:679-94. https://doi.org/10.1259/0007-1285-62-740-679
  14. Dawson LA, Anzai Y, Marsh L, et al. Patterns of localregional recurrence following parotid-sparing conformal and segmental intensity-modulated radiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys 2000;46:1117-26. https://doi.org/10.1016/S0360-3016(99)00550-7
  15. Mackie TR, Holmes T, Swerdloff S, et al. Tomotherapy: a new concept for the delivery of dynamic conformal radiotherapy. Med Phys 1993;20:1709-19. https://doi.org/10.1118/1.596958
  16. Fiorino C, Dell'Oca I, Pierelli A, et al. Significant improvement in normal tissue sparing and target coverage for head and neck cancer by means of helical tomotherapy. Radiother Oncol 2006;78:276-82. https://doi.org/10.1016/j.radonc.2006.02.009
  17. Yao M, Dornfeld KJ, Buatti JM, et al. Intensity-modulated radiation treatment for head-and-neck squamous cell carcinoma: the University of Iowa experience. Int J Radiat Oncol Biol Phys 2005;63:410-21. https://doi.org/10.1016/j.ijrobp.2005.02.025
  18. Sheng K, Molloy JA, Read PW. Intensity-modulated radiation therapy (IMRT) dosimetry of the head and neck: a comparison of treatment plans using linear accelerator-based IMRT and helical tomotherapy. Int J Radiat Oncol Biol Phys 2006;65:917-23. https://doi.org/10.1016/j.ijrobp.2006.02.038
  19. Chen AM, Jennelle RL, Sreeraman R, et al. Initial clinical experience with helical tomotherapy for head and neck cancer. Head Neck 2009;31:1571-8. https://doi.org/10.1002/hed.21123
  20. Chen AM, Li BQ, Farwell DG, Marsano J, Vijayakumar S, Purdy JA. Improved dosimetric and clinical outcomes with intensitymodulated radiotherapy for head-and-neck cancer of unknown primary origin. Int J Radiat Oncol Biol Phys 2011;79:756-62. https://doi.org/10.1016/j.ijrobp.2009.11.020
  21. Clavel S, Nguyen DH, Fortin B, et al. Simultaneous integrated boost using intensity-modulated radiotherapy compared with conventional radiotherapy in patients treated with concurrent carboplatin and 5-fluorouracil for locally advanced oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2012;82:582-9. https://doi.org/10.1016/j.ijrobp.2010.10.061
  22. Madani I, Vakaet L, Bonte K, Boterberg T, De Neve W. Intensitymodulated radiotherapy for cervical lymph node metastases from unknown primary cancer. Int J Radiat Oncol Biol Phys 2008;71:1158-66. https://doi.org/10.1016/j.ijrobp.2007.11.059
  23. Fang FM, Chien CY, Tsai WL, et al. Quality of life and survival outcome for patients with nasopharyngeal carcinoma receiving three-dimensional conformal radiotherapy vs. intensity-modulated radiotherapy-a longitudinal study. Int J Radiat Oncol Biol Phys 2008;72:356-64. https://doi.org/10.1016/j.ijrobp.2007.12.054
  24. Chen WC, Hwang TZ, Wang WH, et al. Comparison between conventional and intensity-modulated post-operative radiotherapy for stage III and IV oral cavity cancer in terms of treatment results and toxicity. Oral Oncol 2009;45:505-10. https://doi.org/10.1016/j.oraloncology.2008.07.002
  25. Yu JB, Soulos PR, Sharma R, et al. Patterns of care and outcomes associated with intensity-modulated radiation therapy versus conventional radiation therapy for older patients with head-and-neck cancer. Int J Radiat Oncol Biol Phys 2012;83:e101-7. https://doi.org/10.1016/j.ijrobp.2011.11.067
  26. Chao KS, Majhail N, Huang CJ, et al. Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma: a comparison with conventional techniques. Radiother Oncol 2001;61:275-80. https://doi.org/10.1016/S0167-8140(01)00449-2
  27. Toledano I, Graff P, Serre A, et al. Intensity-modulated radiotherapy in head and neck cancer: results of the prospective study GORTEC 2004-03. Radiother Oncol 2012;103:57-62. https://doi.org/10.1016/j.radonc.2011.12.010
  28. Lee N, Xia P, Fischbein NJ, Akazawa P, Akazawa C, Quivey JM. Intensity-modulated radiation therapy for head-andneck cancer: the UCSF experience focusing on target volume delineation. Int J Radiat Oncol Biol Phys 2003;57:49-60. https://doi.org/10.1016/S0360-3016(03)00405-X
  29. Chao KS, Ozyigit G, Tran BN, Cengiz M, Dempsey JF, Low DA. Patterns of failure in patients receiving definitive and postoperative IMRT for head-and-neck cancer. Int J Radiat Oncol Biol Phys 2003;55:312-21. https://doi.org/10.1016/S0360-3016(02)03940-8
  30. Van Gestel D, Van Den Weyngaert D, Schrijvers D, Weyler J, Vermorken JB. Intensity-modulated radiotherapy in patients with head and neck cancer: a European single-centre experience. Br J Radiol 2011;84:367-74. https://doi.org/10.1259/bjr/67058055

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  2. Helical Tomotherapy in Head and Neck Cancer: A European Single-Center Experience vol.20, pp.3, 2013, https://doi.org/10.1634/theoncologist.2014-0337
  3. Evaluation of a commercial orthopaedic metal artefact reduction tool in radiation therapy of patients with head and neck cancer. vol.88, pp.1052, 2013, https://doi.org/10.1259/bjr.20140536
  4. The effect of clove-based herbal mouthwash on radiation-induced oral mucositis in patients with head and neck cancer: a single-blind randomized preliminary study vol.9, pp.None, 2013, https://doi.org/10.2147/ott.s108769
  5. The Role of Neoadjuvant Chemotherapy in the Treatment of Nasopharyngeal Carcinoma: A Multi-institutional Retrospective Study (KROG 11-06) Using Propensity Score Matching Analysis vol.48, pp.3, 2013, https://doi.org/10.4143/crt.2015.265
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  7. Concurrent Chemoradiotherapy for Loco-regionally Advanced Nasopharyngeal Carcinoma: Treatment Outcomes and Prognostic Factors vol.19, pp.6, 2013, https://doi.org/10.22034/apjcp.2018.19.6.1591
  8. Efficacy of Carboplatin/Paclitaxel-Based Radiochemotherapy in Locally Advanced Squamous Cell Carcinoma of Head and Neck vol.41, pp.12, 2018, https://doi.org/10.1159/000494031
  9. Application of red light phototherapy in the treatment of radioactive dermatitis in patients with head and neck cancer vol.16, pp.None, 2013, https://doi.org/10.1186/s12957-018-1522-3
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