Parasites, Hosts and Diseases

  • 제51권5호
  • /
  • Pages.583-588
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  • 2013
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  • 2982-5164(pISSN)
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  • 1738-0006(eISSN)
대한기생충학·열대의학회 (The Korea Society for Parasitology and Tropical Medicine)
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Alteration of Cytokine Production during Visceral Larva Migrans by Toxascaris leonina in Mice

  • Kang, Shin Ae (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project) ;
  • Park, Mi-Kyung (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project) ;
  • Cho, Min Kyoung (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project) ;
  • Yu, Hak Sun (Department of Parasitology, School of Medicine, Pusan National University, and Immunoregulatory Therapeutics Group in Brain Busan 21 Project)
  • 투고 : 2013.05.31
  • 심사 : 2013.08.09
  • 발행 : 2013.10.31
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초록

To determine alteration of immune responses during visceral larva migrans (VLM) caused by Toxascaris leonina at several time points, we experimentally infected mice with embryonated eggs of T. leonina and measured T-helper (Th) cell-related serial cytokine production after infection. At day 5 post infection (PI), most larvae were detected from the lungs, spleen, intestine, and muscle. Expression of thymic stromal lymphopoietin (TSLP) and CCL11 (eotaxin) showed a significant increase in most infected organs, except the intestine. However, expression of the CXCL1 (Gro-${\alpha}$) gene was most highly enhanced in the intestine at day 14 PI. Th1-related cytokine secretion of splenocytes showed increases at day 28 PI, and the level showed a decrease at day 42 PI. Th2-related cytokine secretion of splenocytes also showed an increase after infection; in particular, IL-5 level showed a significant increase at day 14 PI, and the level showed a decrease at day 28 PI. However, levels of Th17-related cytokines, IL-6 and IL-17A, showed gradual increases until day 42 PI. In conclusion, Th1, Th2, and Th17-related cytokine production might be important in immune responses against T. leonina VLM in experimental mice.

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