Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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Effect of Geumgoeshingi-Whan Pharmacopuncture on the Blood Pressure in Spontaneously Hypertensive Rats

  • Lee, Meesun (Pusan National University School of Korean Medicine) ;
  • Lee, Sangmi (WUGOH ALS Center of Wonkwang University) ;
  • Jeong, Hohyn (WUGOH ALS Center of Wonkwang University) ;
  • Park, Manyong (WUGOH ALS Center of Wonkwang University) ;
  • Kim, Dong-Woung (Department of Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital) ;
  • Song, Bong-Keun (Department of Oriental Internal Medicine, Wonkwang Gwangju Oriental Medical Hospital) ;
  • Lee, Jong-Deok (Department of Radiology, Wonkwang University College of Korean Medicine) ;
  • Lee, Ho Sub (Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Kim, Sungchul (WUGOH ALS Center of Wonkwang University)
  • Received : 2013.01.10
  • Accepted : 2013.01.29
  • Published : 2013.03.31
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Abstract

Objective: The aim of this experiment was to investigate the effect and the mechanism of Geumgoeshingi-whan (GGSGW) Pharmacopuncture at the acupoint GV 4 on the blood pressure in spontaneously hypertensive rats (SHR). Methods: SHR were injected with normal saline solution (Control-SHR group)or GGSGW Pharmacopuncture (GGSGW-SHR group) at the acupoint GV 4. The systolic arterial blood pressure and renal parameters were measured for two weeks. Results: The systolic arterial blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR, followed by a significant rise in creatine clearance. The plasma levels of aldosterone were decreased significantly after GGSGW Pharmacopunctureas were the plasma levels of atrial natriuretic peptide (ANP). Conclusion: These results suggest that the blood pressure was decreased significantly after GGSGW Pharmacopuncture at the acupoint GV 4 in SHR and that the depressor response of the blood pressure was related to decreases in the plasma levels of aldosterone and ANP.

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References

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