Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Preparation and Characterization of pH-sensitive Sodium Alginate/poly(vinyl alcohol)/bentonite Blend Beads

pH 감응성을 지닌 alginate/poly(vinyl alcohol)/bentonite 블렌드 비드의 제조 및 특성

  • Jeong, Kyung Hui (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University) ;
  • Jung, Young Jin (Department of Biomaterials Science, College of Natural Resources & Life Science, Pusan National University)
  • 정경희 (부산대학교 생명자원과학대학 바이오소재학과) ;
  • 정영진 (부산대학교 생명자원과학대학 바이오소재학과)
  • Received : 2013.10.19
  • Accepted : 2013.11.05
  • Published : 2013.12.01
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Abstract

In order to enhance the drug entrapment efficiency and improve the swelling behaviors of drug delivery system, $Ca_2{^+}$ crosslinking technique was used to prepare sodium alginate/poly(vinyl alcohol)/bentonite blend beads. Beads of different compositions were prepared by varying the amount of bentonite and characterizing it by scanning electron microscopy (SEM). The swelling and pH-sensitive properties of the beads were investigated, and the drug loading and controlled release properties of the beads were also evaluated using diclofenac sodium as the model drug. The results showed that blending PVA and bentonite with alginate beads significantly improved drug encapsulation efficiency, swelling behaviors and drug release property.

Keywords

Acknowledgement

Supported by : 부산대학교

References

  1. K. Park and H. Park, "Smart Hydrogels," in. Concise Polymeric Materials Encyclopedia, (ed.), J. C. Salamone, CRC Press, Boca. Raton, 1999, pp. 1476-1478.
  2. D. Schmaljohann, "Thermo- and pH-responsive polymers in drug delivery," Advanced Drug Delivery Reviews, 58, 1655-1670 (2006). https://doi.org/10.1016/j.addr.2006.09.020
  3. Y. Qiu and K. Park, "Environment-sensitive hydrogels for drug delivery," Advanced Drug Delivery Reviews, 53, 321-339 (2001). https://doi.org/10.1016/S0169-409X(01)00203-4
  4. K. M. Huh, H. C. Kang, Y. J. Lee and Y. H. Bae, "pH-Sensitive Polymers for Drug Delivery," Macromol. Res., 20(3), 224-233 (2012). https://doi.org/10.1007/s13233-012-0059-5
  5. S. J. Hwang, G. J. Rhee, H. B. Jo, K. M. Lee and C. K. Kim, "Alginate Beads as Controlled Release Polymeric Drug Delivery System," J. Kor. Pharm. Sci., 23(1), 19-26 (1993).
  6. J. F. Coelho, P. C. Ferreira, P. Alves, R. Cordeiro, A. C. Fonseca, J. R. Gois and Maria H. Gil, "Drug delivery systems: Advanced technologies potentially applicable in personalized treatments," EPMA Journal, 1, 164-209 (2010). https://doi.org/10.1007/s13167-010-0001-x
  7. H. W. Kim, Y. C. Nho and T. I. Son, "Antibiotic Delivery Characteristic of Poly(vinyl pyrrolidone)/chitosan Hydrogel Prepared by Irradiation," J. Korean Ind. Eng. Chem., 15(3), 283-287 (2004).
  8. O. Munjeri, J. H. Collett and J. T. Fell, "Hydrogel beads based on amidated pectins for colon-specific drug delivery: the role of chitosan in modifying drug release," J. Control. Release, 46(3), 273-278 (1997). https://doi.org/10.1016/S0168-3659(96)01607-0
  9. M. George, T. E. Abraham, "Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan-a review," J. Control. Release, 114, 1-14 (2006). https://doi.org/10.1016/j.jconrel.2006.04.017
  10. P. Matricardi, C. D. Meo, T. Coviello and F. Alhaique, "Recent advances and perspectives on coated alginate microspheres for modified drug delivery," Expert Opinion on Drug Delivery, 5(4), 417-425 (2008). https://doi.org/10.1517/17425247.5.4.417
  11. K. S. V. K. Rao, M. C. S. Subha, B. V. K. Naidu, M. Sairam, N. N. Mallickarjuna and T. M. Aminabhavi, "Contrlled release of diclofenac sodium and ibuprofen through beads of sodium alginate and hydroxyl ethyl cellulose blends," J. Pharm. 331, 61-71 (2007).
  12. J. H. Choi, H. Y. Lee and J. C. Kim, "Release behavior of freezedried alginate beads containing poly(N-isopropylacrylamide) copolymers," J. Appl. Polym. Sci., 2008, 110(1), 117-123 (2008). https://doi.org/10.1002/app.28620
  13. Z. Dong, Q. Wang and Y. Du, "Alginate/gelatin blend films and their properties for drug controlled release," J. Membrane Sci., 280, 37-44 (2006). https://doi.org/10.1016/j.memsci.2006.01.002
  14. M. L. Huguet, R. J. Neufeld and E. Dellacherie, "Calcium-alginate beads coated with polycationic polymers: Comparison of chitosan and DEAE-dextran," Process Biochemistry, 31(4), 347-353 (1996). https://doi.org/10.1016/0032-9592(95)00076-3
  15. S. T. Oh, W. R. Kim, S. H. Kim, Y. C. Chung and Jong-Shin Park, "The Preparation of Polyurethane Foam Combined with pH-sensitive Alginate/Bentonite Hydrogel for Wound Dressings," Fibers and Polymers, 12(2), 159-165 (2011). https://doi.org/10.1007/s12221-011-0159-4
  16. W. F. Lee and Y. C. Chen, "Effect of Bentonite on the Physical Properties and Drug-Release Behavior of Poly(AA-co-PEGMEA)/ Bentonite Nanocomposite Hydrogels for Mucoadhesive," J. Applied Polym Sci., 91(5), 2934-2941 (2004). https://doi.org/10.1002/app.13499
  17. G. H. Gwak, J. M. Oh and J. H. Choy, "Polymer-Inorganic Hybrids for Biomedical Materials," Polym. Sci. and Tech., 23 (2012).
  18. M. Kokabi, M.Sirousazar, Z. M. Hassan, "PVA-clay nanocomposite hydrogels for wound dressing," European Polym. J., 43, 773-781 (2007). https://doi.org/10.1016/j.eurpolymj.2006.11.030
  19. S. Tripathi, G. K. Mehrotra, P. K. Dutta, "Physicochemical and bioactivity of crosslinked chitosan-PVA film for food packaging applications," Int. J. Biol. Macromol., 45, 372-376 (2009). https://doi.org/10.1016/j.ijbiomac.2009.07.006