Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Targeted Gel-Lipid Nanocapsule for Intracellular Delivery of Anticancer Arsenic Trioxide

산화비소가 내포된 표적지향형 겔-리피드 나노캡슐의 제조 및 암세포 증식 억제 효율 분석

  • Lee, Sang-Min (Department of Chemistry, The Catholic University of Korea)
  • Received : 2013.10.11
  • Accepted : 2013.11.15
  • Published : 2013.12.01
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Abstract

Nanoscale drug delivery platforms have been demonstrated to exhibit the high therapeutic potential for cancer treatments by reducing the toxic side effects often associated with conventional small-molecule chemotherapy. However, limited successes have been achieved due to the lack of both targeting ability to particular cancer cells and specific triggers that can release the encapsulated drug under predefined condition. This article reports the formation of nanoscale gel-lipid capsule (GLC) for the delivery of arsenic trioxide anticancer agent. On the platform, the surface-anchored polymer chains form the cross-linked gel networks with alkyne-modified telechelic bis(oxyethylene)diamine linkers, which can trigger the release of encapsulated drug under acidic condition. The alkyne functionality also allows for the ligation of azide-modified folic acid as a targeting ligand via highly specific $Cu^I$-catalyzed [2+3] cycloaddition. The resulting folate-conjugated platform showed enhanced drug efficacy through folate receptor-mediated endocytosis process in KB nasopharyngeal cancer cells. With both targeting capability and acid-triggered drug-release property, GLCs constitute a versatile delivery platform for anticancer agents.

Keywords

Acknowledgement

Supported by : 한국연구재단, 가톨릭대학교

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