Biomaterials Research (생체재료학회지)

Korean Society for Biomaterials (한국생체재료학회)
권호 표지

Bone Regeneration Capacity of Porcine Cancellous Bone and Porcine-based Collagen Membrane in Rabbit Calvarial Defects

토끼 두개골 결손부에서 돼지 해면질골 및 흡수성 콜라겐 차폐막의 골재생 능력

  • Lee, Jae-Hong (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lee, Eun-Ung (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Zhang, Ming-Lan (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lim, Hyun-Chang (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Kim, Young-Taek (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Lee, Jung-Seok (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Jung, Ui-Won (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University) ;
  • Choi, Seong-Ho (Department of periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University)
  • 이재홍 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이은웅 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 장명란 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 임현창 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 김영택 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 이중석 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 정의원 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직재생연구소)
  • Received : 2013.08.29
  • Accepted : 2013.10.10
  • Published : 2013.12.01
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Abstract

The aim of this study was to evaluate bone regeneration following implantation of porcine cancellous bone substitute and collagen membrane in rabbit calvarial defects. Eight male New Zealand rabbits were used and four circular calvarial defects were created on each animal. Defects were filled with different graft materials: 1) collagen membrane, 2) collagen membrane with porcine bone (PB), 3) collagen membrane with bovine bone (BB), and 4) sham control. The animals were sacrificed after 2 and 8 weeks of healing periods for histologic analysis. Both sites receiving PB and BB showed statistically increased augmented volume and new bone formation (p < 0.05). However, there was no statistical difference in new bone formation between the PB, BB and collagen membrane group at all healing periods. Within the limits of this study, collagen membrane with porcine cancellous bone was an effective material for bone regeneration and space maintaining in rabbit calvarial defects.

Keywords

Acknowledgement

Supported by : 연세대학교 치과대학

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