Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of N-Azaaryl Anilines: An Efficient Protocol via Smiles Rearrangement

  • Xia, Shuai (College of Pharmaceutical Sciences, Southwest University) ;
  • Wang, Li-Ying (College of Pharmaceutical Sciences, Southwest University) ;
  • Sun, Heng-Zhi (College of Pharmaceutical Sciences, Southwest University) ;
  • Yue, Huan (College of Pharmaceutical Sciences, Southwest University) ;
  • Wang, Xiu-Hua (College of Pharmaceutical Sciences, Southwest University) ;
  • Tan, Jia-Lian (College of Pharmaceutical Sciences, Southwest University) ;
  • Wang, Yin (College of Pharmaceutical Sciences, Southwest University) ;
  • Hou, Di (College of Pharmaceutical Sciences, Southwest University) ;
  • He, Xiao-Yan (College of Pharmaceutical Sciences, Southwest University) ;
  • Mun, Ki-Cheol (College of Pharmaceutical Sciences, Southwest University) ;
  • Kumar, B. Prem (Department of Chemistry, Changwon National University) ;
  • Zuo, Hua (College of Pharmaceutical Sciences, Southwest University) ;
  • Shin, Dong-Soo (Department of Chemistry, Changwon National University)
  • Received : 2012.09.08
  • Accepted : 2012.11.08
  • Published : 2013.02.20
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Abstract

An efficient process for the synthesis of N-azaaryl anilines via Smiles rearrangement as a tool. A variety of N-azaaryl anilines were generated by the reaction of substituted phenols, substituted anilines, aminopyridines and chloroacetyl chloride or pyridols, under base condition in good to excellent yields.

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References

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