DOI QR코드

DOI QR Code

Abnormality on Liver Function Test

  • Kang, Ki-Soo (Department of Pediatrics, Jeju National University School of Medicine)
  • Received : 2013.11.29
  • Accepted : 2013.12.10
  • Published : 2013.12.30

Abstract

Children with abnormal liver function can often be seen in outpatient clinics or inpatients wards. Most of them have respiratory disease, or gastroenteritis by virus infection, accompanying fever. Occasionally, hepatitis by the viruses causing systemic infection may occur, and screening tests are required. In patients with jaundice, the tests for differential diagnosis and appropriate treatment are important. In the case of a child with hepatitis B virus infection vertically from a hepatitis B surface antigen positive mother, the importance of the recognition of immune clearance can't be overstressed, for the decision of time to begin treatment. Early diagnosis changes the fate of a child with Wilson disease. So, screening test for the disease should not be omitted. Non-alcoholic fatty liver disease, which is mainly discovered in obese children, is a new strong candidate triggering abnormal liver function. Muscular dystrophy is a representative disease mimicking liver dysfunction. Although muscular dystrophy is a progressive disorder, and early diagnosis can't change the fate of patients, it will be better to avoid parent's blame for delayed diagnosis.

Keywords

References

  1. Yazigi N, Balistreri WF. Viral hepatitis. In: Kliegman RM, Stanton BF, St. Geme lll JW, Schor NF, Behrman RE, eds. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier Saunders, 2011:1393-4.
  2. Misdraji J. Embriology, anatomy, histology, and developmental anomalies of the liver. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. 9th ed. Philadelphia: Elsevier Saunders, 2010:1201-6.
  3. McLin VA, Yagzi N. Developmental anatomy and physiology of the liver and bile ducts. In: Wyllie R, Hyams JS, eds. Pediatric gastrointestinal disease. 4th ed. Philadelphia: Elsevier Saunders, 2011:718-27.
  4. Davenport M. Anatomy and embriology. In: Kleinman RE, Sanderson IR, Goulet O, Sherman PM, Mieli- Vergani G, Shneider BL, et al, eds. Walker's pediatric gastrointestinal disease: physiology, diagnosis, management. 5th ed. Hamilton: BC Decker, 2008: 749-66.
  5. Roy-Chowdhury N, Roy-Chowdhury J. Liver physiology and energy metabolism. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. 9th ed. Philadelphia: Elsevier Saunders, 2010:1207-25.
  6. Pratt DS. Liver chemistry and function tests. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. 9th ed. Philadelphia: Elsevier Saunders, 2010:1227-37.
  7. Kim KM. The interpretation of abnormal liver function test in children. In: 2010 Spring Symposium, Seoul: The Society of Korean Pediatric Gastroenteroloy and Nutrition, 2010:70-6.
  8. Bergeron M, Gourley GR. Bilirubin metabolism. In: Kleinman RE, Sanderson IR, Goulet O, Sherman PM, Mieli-Vergani G, Shneider BL, et al, eds. Walker's pediatric gastrointestinal disease: physiology, diagnosis, management. 5th ed. Hamilton: BC Decker, 2008: 749-66.
  9. Cho KY. Hepatitis A. Korean J Pediatr Gastroenterol Nutr 2010;13(Suppl 1):70-7. https://doi.org/10.5223/kjpgn.2010.13.1.70
  10. Kim JH. Recent epidemiological status and vaccination of hepatitis A in Korea. J Korean Med Assoc 2008;51: 110-8. https://doi.org/10.5124/jkma.2008.51.2.110
  11. Youn HS. Current status of hepatitis A virus infections in Korea. Korean J Pediatr 2008;51:690-5. https://doi.org/10.3345/kjp.2008.51.7.690
  12. Choe BH. Hepatitis B vaccine: prevention of perinatal infection and management of nonresponder. Korean J Pediatr Gastroenterol Nutr 2007;10(Suppl 1):91-100.
  13. Choe YH, Seo JK, Yun JH, Lee HS. Recent changesin prevalence of hepatitis B viral markers in preschool children in Seoul, 1995. Korean J Pediatr 1996;39: 1254-9.
  14. Choe BH. Hepatitis B. In: An HS, ed. Hong Change Yee Pediatrics. 10th ed. Seoul: MiraeN Inc., 2012:551-5.
  15. Kang HS, Kang KS, Song BC. Precore and core promoter mutations of the hepatitis B virus gene in chronic genotype C-infected children. J Korean Med Sci 2011;26:546-50. https://doi.org/10.3346/jkms.2011.26.4.546
  16. Park HJ, Chu MA, Hong SJ, Choe B. The rate of conversion to immune-reactive phase form immune-tolerant phase in children with chronic hepatitis B. 4th WCPGHAN 2012 [abstract] book p. 68(OP-1-4-3).
  17. Robert P. Hepatitis B and D. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's gastrointestinal and liver disease. 9th ed. Philadelphia: Elsevier Saunders, 2010:1287-312.
  18. Seo JK. Diagnosis of Wilson disease in young children: molecular genetic testing and a paradigm shift from the laboratory diagnosis. Pediatr Gastroenterol Hepatol Nutr 2012;15:197-209. https://doi.org/10.5223/pghn.2012.15.4.197
  19. Seo JK, Kim JW. Mutation analysis of Wilson disease gene: Arg778Leu mutation in Korean children. Korean J Pediatr Gastroenterol Nutr 1999;2:164-8.
  20. Yang HR, Ko JS, Seo JK. Role of tumor necrosis factor- ${\alpha}$ promoter polymorphism and insulin resistance in the development of non-alcoholic fatty liver disease in obese hildren. Pediatr Gastroenterol Hepatol Nutr 2012;15:44-51. https://doi.org/10.5223/pghn.2012.15.1.44
  21. Sarnat HB. Muscular dystrophies. In: Kliegman RM, Stanton BF, St. Geme lll JW, Schor NF, Behrman RE, eds. Nelson textbook of pediatrics. 19th ed. Philadelphia: Elsevier Saunders, 2011:2119-22.

Cited by

  1. Ablation of Foxl1-Cre-Labeled Hepatic Progenitor Cells and Their Descendants Impairs Recovery of Mice From Liver Injury vol.148, pp.1, 2013, https://doi.org/10.1053/j.gastro.2014.09.039
  2. Paediatric non-alcoholic fatty liver disease: a practical overview for non-specialists vol.100, pp.7, 2013, https://doi.org/10.1136/archdischild-2014-307985
  3. Hepatitis C diagnostic management gap in Pakistan-Clinicians’ knowledge impacting public health vol.24, pp.4, 2013, https://doi.org/10.1007/s10389-016-0725-8
  4. Inulin-type fructans trigger changes in iron concentration and activity of bone metabolism biomarkers in blood plasma of growing pigs vol.25, pp.4, 2013, https://doi.org/10.22358/jafs/67471/2016
  5. Distribution of Diseases Causing Liver Function Test Abnormality in Children and Natural Recovery Time of the Abnormal Liver Function vol.31, pp.11, 2013, https://doi.org/10.3346/jkms.2016.31.11.1784
  6. Imbalance of the antioxidative system by plumbagin and Plumbago indica L. extract induces hepatotoxicity in mice vol.5, pp.2, 2016, https://doi.org/10.5455/jice.20160301094913
  7. Relation between Liver Transaminases and Dyslipidaemia among 2-10 y.o. Northern Mexican Children vol.11, pp.5, 2013, https://doi.org/10.1371/journal.pone.0155994
  8. Safety of intravenously applied mistletoe extract – results from a phase I dose escalation study in patients with advanced cancer vol.17, pp.None, 2013, https://doi.org/10.1186/s12906-017-1971-1
  9. Ratio of Creatine Kinase to Alanine Aminotransferase as a Biomarker of Acute Liver Injury in Dystrophinopathy vol.2018, pp.None, 2018, https://doi.org/10.1155/2018/6484610
  10. Potential Toxicity of the Essential Oil from Minthostachys mollis : A Medicinal Plant Commonly Used in the Traditional Andean Medicine in Peru vol.2019, pp.None, 2013, https://doi.org/10.1155/2019/1987935
  11. A Review on Clinical, Pathophysiological, and Diagnostic Hematological Features in Children With Liver Cirrhosis vol.4, pp.3, 2019, https://doi.org/10.15171/ijbsm.2019.17
  12. Case 3: Persistent Elevated Transaminase Levels in a 9-year-old Boy vol.40, pp.12, 2013, https://doi.org/10.1542/pir.2018-0022
  13. Revision of serum ALT upper limits of normal facilitates assessment of mild liver injury in obese children with non‐alcoholic fatty liver disease vol.34, pp.7, 2013, https://doi.org/10.1002/jcla.23285
  14. The Differences in Transaminase Enzyme Levels among Children with Acute Diarrhea due to Rotavirus and Non-rotavirus vol.9, pp.2, 2013, https://doi.org/10.3889/oamjms.2021.6737
  15. A Multicenter Study of Real-world Practice for Management of Abnormal Liver Function Tests in Children with Acute Infectious Diseases vol.36, pp.47, 2013, https://doi.org/10.3346/jkms.2021.36.e310
  16. GRIM19 Impedes Obesity by Regulating Inflammatory White Fat Browning and Promoting Th17/Treg Balance vol.10, pp.1, 2013, https://doi.org/10.3390/cells10010162
  17. Phytochemical competence and pharmacological perspectives of an endangered boon-Costus speciosus (Koen.) Sm.: a comprehensive review vol.45, pp.1, 2013, https://doi.org/10.1186/s42269-021-00663-2