Pediatric Gastroenterology, Hepatology & Nutrition

The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition (대한소아소화기영양학회)
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Influencing Factors to Results of the Urease Test: Age, Sampling Site, Histopathologic Findings, and Density of Helicobacter pylori

  • Seo, Ji-Hyun (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Youn, Hee-Shang (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Park, Jung-Je (Department of Otolaryngology, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Yeom, Jung Sook (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Park, Ji Sook (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Jun, Jin-Su (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Lim, Jae-Young (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Park, Chan-Hoo (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Woo, Hyang-Ok (Department of Pediatrics, Institute of Health Sciences, School of Medicine, Gyeongsang National University) ;
  • Ko, Gyung-Hyuck (Department of Pathology, Institute of Health Sciences, School of Medicine, Gyeongsang National) ;
  • Baik, Seung-Chul (Department of Microbiology, Institute of Health Sciences, School of Medicine, Gyeongsang National) ;
  • Lee, Woo-Kon (Department of Microbiology, Institute of Health Sciences, School of Medicine, Gyeongsang National) ;
  • Cho, Myung-Je (Department of Microbiology, Institute of Health Sciences, School of Medicine, Gyeongsang National) ;
  • Rhee, Kwang-Ho (Department of Microbiology, Institute of Health Sciences, School of Medicine, Gyeongsang National)
  • Received : 2012.08.11
  • Accepted : 2012.11.30
  • Published : 2013.03.30
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Abstract

Purpose: We investigated the positivity rate and the time period to the positive color change of the urease test in children and adults and assessed the correlation of the urease test to histopathologic findings. Methods: From 1995 to 2000, endoscopic biopsies of the antrum and body were collected from 811 children and 224 adults and subjected to urease tests and histopathology. Results: The positivity rate of the urease test was 49.4% for 0-4 years, 48.4% for 5-9 years, 47.3% for 10-15 years, and 62.5% for 20-29 years in the antrum. The positivity rate was 85.1% in 0-4 years, 82.3% in 5-9 years, 74.7% in 10-15 years, and 74.1% in 20-29 years for the body. In the antrum, the highest positivity rate was <1 hour for the group aged 10-29 years and 6-24 hours in the group <10 years old (p<0.0001). In the body, the highest positivity rate was <1 hour in adults and 6-24 hours in children (p<0.0001). The proportions of the positive reactions within 1 hour were similar for the antrum and the body. In the cases of more severe chronic gastritis, active gastritis, and Helicobacter pylori infiltration, a positive urease test reaction occurred more quickly (p<0.0001). Conclusion: There were significant differences in urease tests according to age and sampling site. The discrepancy between the antrum and the body was greater in younger children. These results might be related to the low density and patchy distribution of bacteria in children and in the body.

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References

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