IMMUNE NETWORK

  • 제13권3호
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  • Pages.81-85
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  • 2013
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  • 1598-2629(pISSN)
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  • 2092-6685(eISSN)
대한면역학회 (The Korean Association of Immunobiologists)
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DOI QR코드

DOI QR Code

Sublingual Delivery of Vaccines for the Induction of Mucosal Immunity

  • Shim, Byoung-Shik (Laboratory Science Division, International Vaccine Institute) ;
  • Choi, Youngjoo (Laboratory Science Division, International Vaccine Institute) ;
  • Cheon, In Su (Laboratory Science Division, International Vaccine Institute) ;
  • Song, Man Ki (Laboratory Science Division, International Vaccine Institute)
  • 투고 : 2013.05.02
  • 심사 : 2013.05.18
  • 발행 : 2013.06.30
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초록

The mucosal surfaces are constantly exposed to incoming pathogens which can cause infections that result in severe morbidity and/or mortality. Studies have reported that mucosal immunity is important for providing protection against these pathogens and that mucosal vaccination is effective in preventing local infections. For many years, the sublingual mucosa has been targeted to deliver immunotherapy to treat allergic hypersensitivities. However, the potential of vaccine delivery via sublingual mucosal has received little attention until recently. Recent studies exploring such potential have documented the safety and effectiveness of sublingual immunization, demonstrating the ability of sublingual immunization to induce both systemic and mucosal immune responses against a variety of antigens, including soluble proteins, inter particulate antigens, and live-attenuated viruses. This review will summarize the recent findings that address the promising potential of sublingual immunization in proving protection against various mucosal pathogens.

키워드

참고문헌

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피인용 문헌

  1. Induction of Intestinal Immunity by Mucosal Vaccines As a Means of Controlling HIV Infection vol.30, pp.11, 2013, https://doi.org/10.1089/aid.2014.0233
  2. Simplifying Influenza Vaccination During Pandemics: Sublingual Priming and Intramuscular Boosting of Immune Responses with Heterologous Whole Inactivated Influenza Vaccine vol.16, pp.2, 2013, https://doi.org/10.1208/s12248-014-9565-z
  3. Mucosal vaccines : Novel strategies and applications for the control of pathogens and tumors at mucosal sites vol.10, pp.8, 2013, https://doi.org/10.4161/hv.29269
  4. Serum and mucosal antibody responses to inactivated polio vaccine after sublingual immunization using a thermoresponsive gel delivery system vol.10, pp.12, 2013, https://doi.org/10.4161/hv.32253
  5. Sublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge vol.10, pp.3, 2013, https://doi.org/10.1371/journal.pone.0119408
  6. A Single Dose Respiratory Recombinant Adenovirus-Based Vaccine Provides Long-Term Protection for Non-Human Primates from Lethal Ebola Infection vol.12, pp.8, 2013, https://doi.org/10.1021/mp500646d
  7. Noninvasive vaccination against infectious diseases vol.14, pp.7, 2013, https://doi.org/10.1080/21645515.2018.1461296
  8. Sublingual Immunization With an RSV G Glycoprotein Fragment Primes IL-17-Mediated Immunopathology Upon Respiratory Syncytial Virus Infection vol.10, pp.None, 2013, https://doi.org/10.3389/fimmu.2019.00567