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A Case of Cardiac Beriberi: A Forgotten but Memorable Disease

  • Lee, Hee-Sun (Cardiovascular Center, Seoul National University Hospital) ;
  • Lee, Seung-Ah (Cardiovascular Center, Seoul National University Hospital) ;
  • Shin, Hyo-Sun (Cardiovascular Center, Seoul National University Hospital) ;
  • Choi, Hong-Mi (Cardiovascular Center, Seoul National University Hospital) ;
  • Kim, Soo-Jung (Cardiovascular Center, Seoul National University Hospital) ;
  • Kim, Hyung-Kwan (Cardiovascular Center, Seoul National University Hospital) ;
  • Park, Young-Bae (Cardiovascular Center, Seoul National University Hospital)
  • Published : 2013.08.30

Abstract

Thiamine (vitamin $B_1$) serves as an important cofactor in body metabolism and energy production. It is related with the biosynthesis of neurotransmitters and the production of substances used in defense against oxidant stress. Thus, a lack of thiamine affects several organ systems, in particular the cardiovascular and nervous system. The cardiac insufficiency caused by thiamine deficiency is known as cardiac beriberi, with this condition resulting from unbalanced nutrition and chronic excessive alcohol intake. Given that the disease is now very rare in developed nations such as Korea, it is frequently missed by cardiologists, with potentially fatal consequences. Herein, we present a case study in order to draw attention to cardiac beriberi. We believe that this case will be helpful for young cardiologists, reminding them of the importance of this forgotten but memorable disease.

Keywords

References

  1. Jones RH Jr. Beriberi heart disease. Circulation 1959;19:275-83. https://doi.org/10.1161/01.CIR.19.2.275
  2. Astudillo L, Degano B, Madaule S, et al. Development of beriberi heart disease 20 years after gastrojejunostomy. Am J Med 2003;115:157-8.
  3. Cappelli V, Bottinelli R, Polla B, Reggiani C. Altered contractile properties of rat cardiac muscle during experimental thiamine deficiency and food deprivation. J Mol Cell Cardiol 1990;22:1095-106. https://doi.org/10.1016/0022-2828(90)90073-B
  4. Sriram K, Manzanares W, Joseph K. Thiamine in nutrition therapy. Nutr Clin Pract 2012;27:41-50. https://doi.org/10.1177/0884533611426149
  5. Wooley JA. Characteristics of thiamin and its relevance to the management of heart failure. Nutr Clin Pract 2008;23:487-93. https://doi.org/10.1177/0884533608323430
  6. Yang JD, Acharya K, Evans M, Marsh JD, Beland S. Beriberi disease: is it still present in the United States? Am J Med 2012;125:e5. https://doi.org/10.1016/S0002-9343(12)00038-1
  7. Towbin A, Inge TH, Garcia VF, et al. Beriberi after gastric bypass surgery in adolescence. J Pediatr 2004;145:263-7. https://doi.org/10.1016/j.jpeds.2004.04.051
  8. Rao SN, Chandak GR. Cardiac beriberi: often a missed diagnosis. J Trop Pediatr 2010;56:284-5. https://doi.org/10.1093/tropej/fmp108
  9. Naidoo DP, Gathiram V, Sadhabiriss A, Hassen F. Clinical diagnosis of cardiac beriberi. S Afr Med J 1990;77:125-7.
  10. Lahey WJ, Arst DB, Silver M, Kleeman CR, Kunkel P. Physiologic observations on a case of beriberi heart disease, with a note on the acute effects of thiamine. Am J Med 1953;14:248-55. https://doi.org/10.1016/0002-9343(53)90023-0
  11. Essa E, Velez MR, Smith S, Giri S, Raman SV, Gumina RJ. Cardiovascular magnetic resonance in wet beriberi. J Cardiovasc Magn Reson 2011;13:41. https://doi.org/10.1186/1532-429X-13-41
  12. Voigt A, Elgeti T, Durmus T, et al. Cardiac magnetic resonance imaging in dilated cardiomyopathy in adults--towards identification of myocardial inflammation. Eur Radiol 2011;21:925-35. https://doi.org/10.1007/s00330-010-1985-2
  13. Lu J, Frank EL. Rapid HPLC measurement of thiamine and its phosphate esters in whole blood. Clin Chem 2008;54:901-6. https://doi.org/10.1373/clinchem.2007.099077
  14. Naidoo DP. Beriberi heart disease in Durban. A retrospective study. S Afr Med J 1987;72:241-4.

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