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The diagnostic efficacy and safety of endobronchial ultrasound-guided transbronchial needle aspiration as an initial diagnostic tool

  • Choi, Young Rak (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • An, Jin Young (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Kim, Mi Kyeong (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Han, Hye-Suk (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Lee, Ki Hyeong (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Kim, Si-Wook (Department of Thoracic Surgery, Chungbuk National University College of Medicine) ;
  • Lee, Ki Man (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Choe, Kang Hyeon (Department of Internal Medicine, Chungbuk National University College of Medicine)
  • 투고 : 2012.07.18
  • 심사 : 2013.02.07
  • 발행 : 2013.11.01

초록

Background/Aims: Real-time, convex probe endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is used for the staging of malignant mediastinal lymph nodes. We evaluated the diagnostic efficacy and safety of EBUS-TBNA when used as an initial diagnostic tool. Methods: We retrospectively studied 56 patients who underwent EBUS-TBNA as an initial diagnostic tool between August 2010 and December 2011. Procedure purpose were classified into four categories: 1) intrathoracic masses adjacent to the central airway; 2) enlarged lymph nodes for concurrent diagnosis and staging in suspected malignancy; 3) enlarged lymph nodes in suspected malignancy cases with inability to perform percutaneous core needle biopsy (PCNB); and 4) solely mediastinal masses/lymph nodes in lieu of mediastinoscopy. Results: The diagnostic accuracy of EBUS-TBNA regardless of procedure purpose was calculated to be 83.9%. Furthermore, the diagnostic accuracy of malignant disease was significantly higher than benign disease (93.9% vs. 70.6%, p < 0.001). The diagnostic accuracy of EBUS-TBNA for each disease is as follows: tuberculosis, 50%; sarcoidosis, 60%; aspergillosis, 100%; lung abscess, 100%; lung cancer, 93%; and lymphoma, 100%. There were minor complications in seven patients during the EBUS-TBNA procedure. The complications included mild hypoxia and bleeding. Conclusions: In conclusion, EBUS-TBNA is a useful initial diagnostic tool for both benign and malignant diseases. EBUS-TBAN is also a very safe procedure and less invasive compared to mediastinoscopy or PCNB.

키워드

참고문헌

  1. Kang YH, Choi IS, Jung IJ, et al. Clinical evaluation on transbronchial needle aspiration (TBNA) of subcarinal lymph node in lung cancer. Tuberc Respir Dis 1993;40:177-184.
  2. Nakajima T, Yasufuku K, Fujiwara T, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for the diagnosis of intrapulmonary lesions. J Thorac Oncol 2008;3:985-988. https://doi.org/10.1097/JTO.0b013e31818396b9
  3. Tournoy KG, Rintoul RC, van Meerbeeck JP, et al. EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy. Lung Cancer 2009;63:45-49. https://doi.org/10.1016/j.lungcan.2008.04.004
  4. Vincent BD, El-Bayoumi E, Hoffman B, et al. Real-time endobronchial ultrasound-guided transbronchial lymph node aspiration. Ann Thorac Surg 2008;85:224-230. https://doi.org/10.1016/j.athoracsur.2007.07.023
  5. Hu H, Chen HQ, Chen Y, et al. Evaluation of the value of EBUS-TBNA in diagnosis of mediastinal lesions. Zhonghua Zhong Liu Za Zhi 2011;33:787-790.
  6. Hong GH, Lee KJ, Jeon KM, et al. The usefulness of EBUS-TBNA for the diagnosis of sarcoidosis. Tuberc Respir Dis 2011;112(Suppl):83.
  7. Kuo CH, Chen HC, Chung FT, et al. Diagnostic value of EBUS-TBNA for lung cancer with non-enlarged lymph nodes: a study in a tuberculosis-endemic country. PLoS One 2011;6:e16877. https://doi.org/10.1371/journal.pone.0016877
  8. Lee HS, Lee GK, Lee HS, et al. Real-time endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal staging of non-small cell lung cancer: how many aspirations per target lymph node station? Chest 2008;134:368-374. https://doi.org/10.1378/chest.07-2105
  9. Kramer H, Groen HJ. Current concepts in the mediastinal lymph node staging of nonsmall cell lung cancer. Ann Surg 2003;238:180-188.
  10. Cetinkaya E, Gunluoglu G, Ozgul A, et al. Value of real-time endobronchial ultrasound-guided transbronchial needle aspiration. Ann Thorac Med 2011;6:77-81. https://doi.org/10.4103/1817-1737.78422
  11. Patelli M, Lazzari Agli L, Poletti V, et al. Role of fiberscopic transbronchial needle aspiration in the staging of N2 disease due to non-small cell lung cancer. Ann Thorac Surg 2002;73:407-411. https://doi.org/10.1016/S0003-4975(01)03447-6
  12. Wang KP, Brower R, Haponik EF, Siegelman S. Flexible transbronchial needle aspiration for staging of bronchogenic carcinoma. Chest 1983;84:571-576. https://doi.org/10.1378/chest.84.5.571
  13. Medford AR, Bennett JA, Free CM, Agrawal S. Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA): applications in chest disease. Respirology 2010;15:71-79. https://doi.org/10.1111/j.1440-1843.2009.01652.x
  14. Kennedy MP, Jimenez CA, Bruzzi JF, et al. Endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lymphoma. Thorax 2008;63:360-365. https://doi.org/10.1136/thx.2007.084079
  15. Agarwal R, Khan A, Aggarwal AN, Gupta D. Efficacy & safety of iodopovidone pleurodesis: a systematic review & meta-analysis. Indian J Med Res 2012;135:297-304.
  16. Jernlas B, Nyberger H, Ek L, Ohman R, Jonsson P, Nozohoor S. Diagnostic yield and efficacy of endobronchial ultrasound-guided transbronchial needle aspiration in mediastinal lymphadenopathy. Clin Respir J 2012;6:88-95. https://doi.org/10.1111/j.1752-699X.2011.00251.x
  17. Hu J, Su YH, Yin X, et al. Evaluation of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of hilar and mediastinal masses of unknown etiologies. Zhonghua Yi Xue Za Zhi 2012;92:528-531.
  18. Wahidi MM, Rocha AT, Hollingsworth JW, Govert JA, Feller-Kopman D, Ernst A. Contraindications and safety of transbronchial lung biopsy via flexible bronchoscopy: a survey of pulmonologists and review of the literature. Respiration 2005;72:285-295. https://doi.org/10.1159/000085370
  19. Ernst A, Eberhardt R, Wahidi M, Becker HD, Herth FJ. Effect of routine clopidogrel use on bleeding complications after transbronchial biopsy in humans. Chest 2006;129:734-737. https://doi.org/10.1378/chest.129.3.734
  20. Herth FJ, Becker HD, Ernst A. Aspirin does not increase bleeding complications after transbronchial biopsy. Chest 2002;122:1461-1464. https://doi.org/10.1378/chest.122.4.1461

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  4. Diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration in various lung diseases vol.41, pp.5, 2013, https://doi.org/10.1590/s1806-37132015000004493
  5. Diagnostic value of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in solitary mediastinal, hilar lymphadenectasis, or peribronchial lesions : Six cases reports and revi vol.95, pp.44, 2013, https://doi.org/10.1097/md.0000000000005249
  6. Endobronchial ultrasound guided transbronchial needle aspiration combining with immunohistochemistry and genotype in lung cancer: A single-center, 55 cases retrospective study vol.23, pp.None, 2013, https://doi.org/10.1016/j.amsu.2017.07.055
  7. Endobronchial Ultrasound-guided Transbronchial Needle Aspiration Increases the Yield of Transbronchial Lung Biopsy for the Evaluation of Peribronchial Lesions vol.130, pp.1, 2013, https://doi.org/10.4103/0366-6999.196567
  8. Safety of endobronchial ultrasound‐guided transbronchial needle aspiration in patients with lung cancer within a year after percutaneous coronary intervention vol.9, pp.11, 2018, https://doi.org/10.1111/1759-7714.12846
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  10. Contrast-enhanced ultrasound for needle biopsy of thoracic lesions vol.20, pp.4, 2013, https://doi.org/10.3892/ol.2020.11936
  11. Diagnostic efficacy of EBUS‐TBNA in benign diseases in a population with a high prevalence of tuberculosis vol.49, pp.3, 2013, https://doi.org/10.1002/dc.24661