The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Current evidence of effects of Helicobacter pylori eradication on prevention of gastric cancer

  • Choi, Il Ju (Center for Gastric Cancer, National Cancer Center)
  • Received : 2013.07.31
  • Accepted : 2013.08.01
  • Published : 2013.09.01
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Abstract

Gastric cancer is the second most common cause of cancer death worldwide and is usually detected at a late stage, except in Korea and Japan where early screening is in effect. Results from animal and epidemiological studies suggest that Helicobacter pylori infection, and subsequent gastritis, promote development of gastric cancer in the infected mucosa. Relatively effective treatment regimens are available to treat H. pylori infection, and in general, mass eradication of the organism is not currently recommended as a gastric cancer prevention strategy. However, regional guidelines vary regarding the indications and recommendations for H. pylori treatment for gastric cancer prevention. In this review, we discuss the results from intervention studies, provide insight regarding current guideline recommendations, and discuss future study directions.

Keywords

References

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