Tuberculosis and Respiratory Diseases

  • 제74권5호
  • /
  • Pages.235-239
  • /
  • 2013
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  • 1738-3536(pISSN)
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  • 2005-6184(eISSN)
대한결핵및호흡기학회 (The Korean Academy of Tuberculosis and Respiratory Diseases)
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Fatal Interstitial Pneumonitis Rapidly Developed after the First Cycle of CHOP with Etoposide Combination Chemotherapy in a Patient with Lymphoma

  • Park, Hyung Chul (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Ahn, Jae-Sook (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Yang, Deok-Hwan (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Jung, Sung-Hoon (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Oh, In-Jae (Department of Pulmonology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Choi, Song (Department of Radiology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Lee, Seung-Shin (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Kim, Mi-Young (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Kim, Yeo-Kyeoung (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Kim, Hyeoung-Joon (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School) ;
  • Lee, Je-Jung (Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Chonnam National University Medical School)
  • 투고 : 2012.06.04
  • 심사 : 2012.10.05
  • 발행 : 2013.05.30
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초록

Several chemotherapeutic agents are known to develop pulmonary toxicities in cancer patients, although the frequency of incidence varies. Cyclophosphamide is a commonly encountered agent that is toxic to the lung. Additionally, granulocyte colony-stimulating factor (G-CSF) being used for the recovery from neutropenia can exacerbate lung injury. However, most of the patients reported previously that the drug-induced interstitial pneumonitis were developed after three to four cycles of chemotherapy. Hereby, we report a case of peripheral T cell lymphoma which rapidly developed a fatal interstitial pneumonitis after the first cycle of combined chemotherapy with cyclophosphamide, adriamycin, vincristine, prednisolone, and etoposide and the patient had also treated with G-CSF during neutropenic period.

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참고문헌

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피인용 문헌

  1. Cyclophosphamide/lenograstim : Interstitial pneumonitis in an elderly patient: case report vol.1462, pp.1, 2013, https://doi.org/10.1007/s40278-013-4732-z