Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Effects of Butyrate on Colorectal Cancer

대장암에 대한 butyrate의 효과

  • Jin, Ji Young (Department of Biological Science, Silla University) ;
  • Cho, Kwang Keun (Department of Animal Resources Technology, Gyeongnam National University of Science and Technology) ;
  • Choi, In Soon (Department of Biological Science, Silla University)
  • 진지영 (신라대학교 생물과학과) ;
  • 조광근 (경남과학기술대학교 동물소재공학과) ;
  • 최인순 (신라대학교 생물과학과)
  • Received : 2013.01.16
  • Accepted : 2013.01.25
  • Published : 2013.01.30
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Abstract

Due to the high incidence of cancer and cancer-related mortality in Korea, there is increased concern and psychological anxiety about this disease, leading to increasing numbers of cancer studies. Despite these, the trend of the cancer incidence rate has shown a significant increase. The detection of colorectal cancer, which has a high incidence rate, often tends to be delayed, causing a high mortality rate. Therefore, the prevention of colorectal cancer has become an important emergent issue. The cause of this cancer has not been confirmed. However, it may be attributable to westernized dietary patterns, which include consuming a high quantity of red meat. Consumption of dietary fiber promotes the production of butyrate short-chain fatty acids by enteric bacteria. In the treatment of cancer, anticancer medications have been shown to lead to the apoptosis of tumor cells, and a strong relationship between apoptosis mechanisms of tumor cells and cancer treatment has been confirmed. The results of many studies have confirmed that butyrate can directly promote the apoptosis of colorectal cancer cells. Therefore, increased consumption of dietary fiber, which promotes the production of butyrate shortchain fatty acids, can be expected to have an effect on the prevention and treatment of colorectal cancer.

현재 우리나라는 높은 암 발생률과 사망률로 인해 암에 대한 관심과 심리적 불안감이 높아지고 있고, 따라서 많은 연구가 진행되고 있는 실정이다. 그럼에도 불구하고 암 발생률 빈도는 현저하게 증가하고 있는 추세이며, 그 중에서도 발병률이 높은 대장암은 발견 또한 늦어 사망률이 높다. 따라서 대장암의 예방이 무엇보다도 시급하다. 원인은 아주 다양하면서도 정확하게 규명되진 않았지만, 가장 크게 식생활의 서구화로 인한 결과로 여겨진다. 육류 위주의 서구식 식이습관 개선을 위해 식이섬유를 풍부하게 섭취하게 되면 항암제 역할을 하는 단쇄지방산인 butyrate가 위장관 내에서 장내 미생물에 의해 발생된다. 암의 치료에 있어서 항암제들은 종양세포의 apoptosis를 유도한다는 것이 알려졌고, 종양세포의 apoptosis 기전과 암의 치유기전 사이에는 서로 깊은 연관이 있음이 확인되었다. 따라서 butyrate가 직접적으로 대장암 세포의 apoptosis를 일으킴으로써 대장암을 억제하는 효과를 연구결과들을 통해서 확인하였고, 이는 대장암의 예방 및 치료에 직접적으로 영향을 미칠 것을 기대한다.

Keywords

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