Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

  • Chen, Yao-Sheng (Department of Gastroenterology, Yangzhou NO.1 People's Hospital) ;
  • Xu, Song-Xin (Department of Gastroenterology, Yangzhou NO.1 People's Hospital) ;
  • Ding, Yan-Bing (Department of Gastroenterology, Yangzhou NO.1 People's Hospital) ;
  • Huang, Xin-En (Department of Chemotherapy, the Affiliated Jiangsu Cancer Hospital of Nanjing Medical University and Jiangsu Institute of Cancer Research) ;
  • Deng, Bin (Department of Gastroenterology, Yangzhou NO.1 People's Hospital)
  • Published : 2013.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Background and Aims: Helicobacter pylori infection may be associated with an increased risk of colorectal carcinoma. However, as most studies on this subject were relatively small in size and differed at least partially in their designs, their results remain controversial. In this study, we aimed to carry out a meta-analysis to evaluate the potential association of H. pylori infection with colorectal adenoma and adenocarcinoma risk, covering all of the different testing methods. Methods: We conducted a search in PubMed, Medline, EBSCO, High Wire Press, OVID, and EMBASE covering all published papers up to March 2013. According to the established inclusion criteria, essential data were then extracted from the included studies and further analyzed by a systematic meta-analysis. Odds ratios were employed to evaluate the relationship between H. pylori infection and the risk of colorectal neoplasms. Results: Twenty-two studies were included, and the odds ratio for the association between H. pylori infection and colorectal cancer was 1.49 (95% confidence interval 1.30-1.72). No statistically significant heterogeneity was observed. Publication bias was ruled out. Conclusion: The pooled data suggest H. pylori infection indeed increases the risk of colorectal adenoma and adenocarcinoma.

Keywords

References

  1. Abbass K, Gul W, Beck G, Markert R, Akram S (2011). Association of Helicobacter pylori infection with the development of colorectal polyps and colorectal carcinoma. South Med J, 104, 473-6. https://doi.org/10.1097/SMJ.0b013e31821e9009
  2. Ai Machida-Montani, Shizuka Sasazuki, Manami Inoue, et al (2007). atrophic gastritis, helicobacter pylori, and colorectal cancerrisk: a case-control study. Helicobacter, 12, 328-32. https://doi.org/10.1111/j.1523-5378.2007.00513.x
  3. Beales IL, Crabtree JE, Scunes D, et al (1996). Antibodies to CagA protein are associatedwith gastric atrophy in Helicobacter pylori infection. Eur J Gastroenterol Hepatol, 8, 645-9.
  4. Breuer-Katschinski B, Nemes K, Marr A, et al (1999). Helicobacter pylori and the risk of colonic adenomas. Colorectal Adenoma Study Group. Digestion, 60, 210-5. https://doi.org/10.1159/000007661
  5. Bulajic M, Stimec B, Jesenofsky R, et al (2007). Helicobacter pylori in colorectal carcinomatissue. Cancer Epidemiol Biomarkers Prev, 16, 631-3. https://doi.org/10.1158/1055-9965.EPI-06-1031
  6. Buso AG, Rocha HL, Diogo DM, Diogo PM, Diogo-Filho A (2009). Seroprevalence of Helicobacter pylori in patients with colon adenomas in a Brazilian university hospital. Arq Gastroenterol, 46, 97-101. https://doi.org/10.1590/S0004-28032009000200004
  7. Chen TS, Chang FY, Chen PC, et al (2003). Simplified 13C-urea breath test with a newinfrared spectrometer for diagnosis of Helicobacter pylori infection. J Gastroenterol Hepatol, 18, 1237-43. https://doi.org/10.1046/j.1440-1746.2003.03139.x
  8. De Luca A, Iaquinto G (2004). Helicobacter pylori and gastric diseases: a dangerousassociation. Cancer Lett, 213, 1-10. https://doi.org/10.1016/j.canlet.2004.06.006
  9. Deng QQ, Huang XE, Ye LH, et al (2013). Phase II trial of Loubo(R) (Lobaplatin) and pemetrexed for patients with metastatic breast cancer not responding to anthracycline or taxanes. Asian Pac J Cancer Prev, 14, 413-7. https://doi.org/10.7314/APJCP.2013.14.1.413
  10. Engle SJ, Ormsby I, Pawlowski S, et al (2002). Elimination of colon cancer in germ-freetransforming growth factor beta1-deficient mice. Cancer Res, 62, 6362-6.
  11. Erdman SE, Poutahidis T, Tomczak M, et al (2003). CD41 CD251 regulatory T lymphocytesinhibit microbially induced colon cancer in Rag2-deficient mice. Am JPathol, 162, 691-702.
  12. Fearon ER, Vogelstein B (1990). A genetic model for colorectal tumorigenesis. Cell, 61, 759-67. https://doi.org/10.1016/0092-8674(90)90186-I
  13. Fireman Z, Trost L, Kopelman Y, Segal A, Sternberg A (2000). Helicobacter pylori: seroprevalence and colorectal cancer. Isr Med Assoc J, 2, 6-9.
  14. Fujimori S, Kishida T, Kobayashi T, et al (2005). Helicobacter pylori infection increases the risk of colorectal adenomaand adenocarcinoma, especially in women. J Gastroenterol, 40, 887-93. https://doi.org/10.1007/s00535-005-1649-1
  15. Gao LL, Huang XE, Zhang Q, et al (2011). A Cisplatin and vinorelbine (NP) regimen as a postoperative adjuvant chemotherapy for completely resected breast cancers in China: final results of a phase II clinical trial. Asian Pac J Cancer Prev, 12, 77-80.
  16. Georgopoulos SD, Polymeros D, Triantafyllou K, et al (2006). Hypergastrinemia is associatedwith increased risk of distal colon adenomas. Digestion, 74, 42-6. https://doi.org/10.1159/000096593
  17. Gong P, Huang XE, Chen CY, et al (2012). Comparison on complications of peripherally inserted central catheters by ultrasound guide or conventional method in cancer patients. Asian Pac J Cancer Prev, 13, 1873-5. https://doi.org/10.7314/APJCP.2012.13.5.1873
  18. Grahn N, Hmani-Aifa M, Fransen K, et al (2005). Molecular identification of HelicobacterDNA present in human colorectal adenocarcinomas by 16s rDNA PCRamplification andpyrosequencing analysis. J Med Microbiol, 54, 1031-5. https://doi.org/10.1099/jmm.0.46122-0
  19. Gu M, Li SY, Huang XE, et al (2013). A phase II study on continuous infusional paclitaxel and 5-Fu as first-line chemotherapy for patients with advanced esophageal cancer. Asian Pac J Cancer Prev, 13, 5587-91. https://doi.org/10.7314/APJCP.2012.13.11.5587
  20. Hartwich A, Konturek SJ, Pierzchalski P, et al (2001). Helicobacter pyloriinfection, gastrin, cyclooxygenase-2, and apoptosis in colorectal cancer. Int J Colorectal Dis, 16, 202-10. https://doi.org/10.1007/s003840100288
  21. Huang XE, Li CG, Li Y, et al (2011). Weekly TP regimen as a postoperative adjuvant chemotherapy for completely resected breast cancer in China: final result of a phase II trial. Asian Pac J Cancer Prev, 12, 2797-800.
  22. Huang XE, Wei GL, Huo JG, et al (2013). Intrapleural or intraperitoneal lobaplatin for treatment of patients with malignant pleural effusion or ascites. Asian Pac J Cancer Prev, 14, 2611-4. https://doi.org/10.7314/APJCP.2013.14.4.2611
  23. Inoue I, Mukoubayashi C, Yoshimura N, et al (2011). Elevated risk of colorectal adenoma with Helicobacter pylori-related chronic gastritis: apopulation-basedcase-control study. Int J Cancer, 129, 2704-11. https://doi.org/10.1002/ijc.25931
  24. Jemal A, Center MM, Ward E, Thun MJ (2009). Cancer occurrence.Methods Mol Biol, 471, 3-29. https://doi.org/10.1007/978-1-59745-416-2_1
  25. Jiang Y, Huang XE, Yan PW, et al (2010). Validation of treatment efficacy of a computer-assisted program for breast cancer patients receiving postoperative adjuvant chemotherapy. Asian Pac J Cancer Prev, 11, 1059-62.
  26. Jones M, Helliwell P, Pritchard C, et al (2007). Helicobacter pylori in colorectalneoplasms: is there an aetiological relationship? World J Surg Oncol, 5, 51. https://doi.org/10.1186/1477-7819-5-51
  27. Korkmaz H, Kesli R, Karabagli P, Terzi Y (2013). Comparison of the diagnostic accuracy of five different stool antigen tests for the diagnosis of Helicobacter pylori infection. Helicobacter, 18, 384-91. https://doi.org/10.1111/hel.12053
  28. Li CG, Huang XE, Li Y, et al (2011). Clinical observations on safety and efficacy of OxyContin administered by rectal route in treating cancer related pain. Asian Pac J Cancer Prev, 12, 2477-8.
  29. Li CG, Huang XE, Xu L, et al (2012). Clinical application of serum tumor associated material (TAM) from non-small cell lung cancer patients. Asian Pac J Cancer Prev, 13, 301-4. https://doi.org/10.7314/APJCP.2012.13.1.301
  30. Li CG, Huang XE, Li Y, et al (2011). Phase II trial of irinotecan plus nedaplatin (INP) in treating patients with extensive stage small cell lung cancer. Asian Pac J Cancer Prev, 12, 487-90.
  31. Limburg PJ, Stolzenberg-Solomon RZ, Colbert LH, et al (2002). Helicobacter pylori seropositivity and colorectal cancer risk: a prospective study of male smokers.Cancer Epidemiol Biomarkers Prev, 11, 1095-9.
  32. Li Y, Yan PW, Huang XE, et al (2011). MDR1 gene C3435T polymorphism is associated with clinical outcomes in gastric cancer patients treated with postoperative adjuvant chemotherapy. Asian Pac J Cancer Prev, 12, 2405-9.
  33. Liou JM, Lin JW, Huang SP, et al (2006). Helicobacter pylori infection is not associatedwith increased risk of colorectal polyps in Taiwanese. Int J Cancer, 119, 1999-2000. https://doi.org/10.1002/ijc.22050
  34. Liu J, Huang XE, Tian GY, et al (2013). Phase II study on safety and efficacy of Yadanzi(R) (Javanica oil emulsion injection) combined with chemotherapy for patients with gastric cancer. Asian Pac J Cancer Prev, 14, 2009-12. https://doi.org/10.7314/APJCP.2013.14.3.2009
  35. Liu W, Li SY, Huang XE, et al (2012). Inhibition of tumor growth in vitro by a combination of extracts from rosa roxburghii tratt and fagopyrum cymosum. Asian Pac J Cancer Prev, 13, 2409-14. https://doi.org/10.7314/APJCP.2012.13.5.2409
  36. Liu YC, Zhou SB, Gao F, et al (2013). Chemotherapy and late course three dimensional conformal radiotherapy for treatment of patients with stage III non- small cell lung cancer. Asian Pac J Cancer Prev, 14, 2663-5. https://doi.org/10.7314/APJCP.2013.14.4.2663
  37. Lochhead P, El-Omar EM (2007). Helicobacter pylori infection and gastric cancer. BestPract Res Clin Gastroenterol, 21, 281-97. https://doi.org/10.1016/j.bpg.2007.02.002
  38. Lu YY, Huang XE, Cao J, et al (2013). Phase II study on Javanica oil emulsion injection (Yadanzi(R)) combined with chemotherapy in treating patients with advanced lung adenocarcinoma. Asian Pac J Cancer Prev, 14, 4791-4. https://doi.org/10.7314/APJCP.2013.14.8.4791
  39. Maeda S, Mentis AF (2007). Pathogenesis of Helicobacter pylori infection. Helicobacter, 12, 10-4. https://doi.org/10.1111/j.1523-5378.2007.00529.x
  40. Meucci G, Tatarella M, Vecchi M, et al (1997). High prevalence of Helicobacter pylori infection in patients with colonic adenomas and carcinomas. J Clin Gastroenterol, 25, 605-7. https://doi.org/10.1097/00004836-199712000-00011
  41. Mizuno S, Morita Y, Inui T, et al (2005). Helicobacter pylori infection is associated with colon adenomatous polyps detectedby high-resolution colonoscopy. Int J Cancer, 117, 1058-9. https://doi.org/10.1002/ijc.21280
  42. Moss SF, Neugut AI, Garbowski GC, et al (1995). Helicobacter pylori seroprevalence and colorectalneoplasia: evidence against an association. J Natl Cancer Inst, 87, 762-33 https://doi.org/10.1093/jnci/87.10.762
  43. Mulholland G, Ardill JE, Fillmore D, et al (1993). Helicobacter pylori related hypergastrinaemiais the result of a selective increase in gastrin 17. Gut, 34, 757-61. https://doi.org/10.1136/gut.34.6.757
  44. Penman ID, el-Omar E, Ardill JE, et al (1994). Plasma gastrin concentrations arenormal in patients with colorectal neoplasia and unalteredfollowing tumor resection. Gastroenterology, 106, 1263-70. https://doi.org/10.1016/0016-5085(94)90018-3
  45. Shmuely H, Passaro D, Figer A, et al (2001). Relationship between Helicobacter pylori CagA status and colorectal cancer. Am J Gastroenterol, 96, 3406-10. https://doi.org/10.1111/j.1572-0241.2001.05342.x
  46. Shu J, Li CG, Liu YC, et al (2012). Comparison of Serum Tumor Associated Material (TAM) with Conventional Biomarkers in Cancer Patients. Asian Pac J Cancer Prev, 13, 2399-403. https://doi.org/10.7314/APJCP.2012.13.5.2399
  47. Siddheshwar RK, Muhammad KB, Gray JC, Kelly SB (2001). Seroprevalence of Helicobacter pylori in patients with colorectal polyps and colorectal carcinoma. Am J Gastroenterol, 96, 84-8. https://doi.org/10.1111/j.1572-0241.2001.03355.x
  48. Sobhani I, Lehy T, Laurent-Puig P, et al (1993). Chronic endogenous hypergastrinemiain humans: evidence for a mitogenic effect on the colonic mucosa. Gastroenterology, 105, 2-30.
  49. Sonnenberg A, Genta RM (2013). Helicobacter pylori is a risk factor for colonic neoplasms. Am J Gastroenterol, 108, 208-15. https://doi.org/10.1038/ajg.2012.407
  50. Strofilas A, Lagoudianakis EE, Seretis C, et al (2012). Association of Helicobacter pylori infection and colon cancer. J Clin Med Res, 4, 172-6.
  51. Sun MQ, Meng AF, Huang XE, et al (2013). Comparison of psychological influence on breast cancer patients between breast-conserving surgery and modified radical mastectomy. Asian Pac J Cancer Prev, 14, 149-52. https://doi.org/10.7314/APJCP.2013.14.1.149
  52. Talley NJ, Zinsmeister AR, Weaver A, et al (1991). Gastric adenocarcinoma andHelicobacter pylori infection. J Natl Cancer Inst, 83, 1734-9. https://doi.org/10.1093/jnci/83.23.1734
  53. Tenesa A, Dunlop MG (2009). New insights into the aetiology of colorectalcancer from genome-wide association studies. Nat Rev Genet, 10, 353-8.
  54. Thorburn CM, Friedman GD, Dickinson CJ, et al (1998). Gastrin and colorectal cancer:a prospective study. Gastroenterology, 115, 275-80. https://doi.org/10.1016/S0016-5085(98)70193-3
  55. Wu IC, Wu DC, Yu FJ, et al (2009). Association between Helicobacter pylori seropositivity anddigestive tract cancers. World J Gastroenterol, 15, 5465-71. https://doi.org/10.3748/wjg.15.5465
  56. Xu HX, Huang XE, Li Y, et al (2011). A clinical study on safety and efficacy of Aidi injection combined with chemotherapy. Asian Pac J Cancer Prev, 12, 2233-6.
  57. Xu HX, Huang XE, Qian ZY, et al (2011). Clinical observation of Endostar combined with chemotherapy in advanced colorectal cancer patients. Asian Pac J Cancer Prev, 12, 3087-90.
  58. Xu HX, Huang XE, Qian ZY, et al (2011). Clinical observation of Endostar(R) combined with chemotherapy in advanced colorectal cancer patients. Asian Pac J Cancer Prev, 12 (11):3087-90.
  59. Xu JW, Li CG, Huang XE, et al (2011). Ubenimex capsule improves general performance and chemotherapy related toxicity in advanced lung adenocarcinoma cases. Asian Pac J Cancer Prev, 12, 985-7.
  60. Xu T, Xu ZC, Zou Q, Yu B, Huang XE (2012). P53 Arg72Pro polymorphism and bladder cancer risk--meta-analysis evidence for a link in Asians but not Caucasians. Asian Pac J Cancer Prev, 13, 2349-54. https://doi.org/10.7314/APJCP.2012.13.5.2349
  61. Xu X, Wang L, Xu HQ, Huang XE, et al (2013). Clinical comparison between paclitaxel liposome (Lipusu(R)) and paclitaxel for treatment of patients with metastatic gastric cancer. Asian Pac J Cancer Prev, 14, 2591-4. https://doi.org/10.7314/APJCP.2013.14.4.2591
  62. Yan PW, Huang XE, Jiang Y, et al (2010). A clinical comparison on safety and efficacy of Paclitaxel/Epirubicin (NE) with Fluorouracil/Epirubicin/Cyclophosphamide (FEC) as postoperative adjuvant chemotherapy in breast cancer. Asian Pac J Cancer Prev, 11, 1115-8.
  63. Yan PW, Huang XE, Jiang Y, et al (2010). A clinical comparison on safety and efficacy of Paclitaxel/Epirubicin (NE) with Fluorouracil/Epirubicin/Cyclophosphamide (FEC) as postoperative adjuvant chemotherapy in breast cancer. Asian Pac J Cancer Prev, 11, 1115-8.
  64. Yan PW, Huang XE, Yan F, et al (2011). Influence of MDR1 gene codon 3435 polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancer. Asian Pac J Cancer Prev, 12, 2291-4.
  65. Yin HT, Zhang DG, Wu XL, Huang XE, Chen G (2013). In vivo evaluation of curcumin-loaded nanoparticles in a A549 xenograft mice model. Asian Pac J Cancer Prev, 14, 409-12. https://doi.org/10.7314/APJCP.2013.14.1.409
  66. Yu DS, Huang XE, Zhou JN, et al (2012). Comparative study on the value of anal preserving surgery for aged people with low rectal carcinoma in Jiangsu, China. Asian Pac J Cancer Prev, 13, 2339-40. https://doi.org/10.7314/APJCP.2012.13.5.2339
  67. Zhan YP, Huang XE, Cao J, Clinical study on safety and efficacy of Qinin (cantharidin sodium) injection combined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev, 13, 4773-6. https://doi.org/10.7314/APJCP.2012.13.9.4773
  68. Zhan YP, Huang XE, Cao J (2012). Clinical safety and efficacy of Kanglaite (Coix Seed Oil) injection combined with chemotherapy in treating patients with gastric cancer. Asian Pac J Cancer Prev, 13, 5319-21. https://doi.org/10.7314/APJCP.2012.13.10.5319
  69. Zhang LQ, Huang XE, Wang J (2011). The cyclin D1 G870A polymorphism and colorectal cancer susceptibility: a metaanalysis of 20 populations. Asian Pac J Cancer Prev, 12, 81-5.
  70. Zhang XZ, Huang XE, Xu YL, et al (2012). A phase II study on Voriconazole in treating Chinese patients with malignant hematological disorder and invasive aspergillosis. Asian Pac J Cancer Prev, 13, 2415-8. https://doi.org/10.7314/APJCP.2012.13.5.2415
  71. ZhangYan, Michael Hoffmeister, Melanie N. Weck, et al (2012). Helicobacter pylori infection and colorectal cancer risk: evidence from a large population-based case-control study in Germany. Am J Epidemiol, 175, 441-50. https://doi.org/10.1093/aje/kwr331
  72. Zhou JN, Huang XE, Ye Z, et al (2009). Weekly paclitaxel/Docetaxel combined with a paltinum in the treatment of advanced non-samll cell lung cancer: a study on efficacy, safety and pre-medication. Asian Pac J Cancer Prev, 10, 1147-50.
  73. Zhu Y, Wu H, Wang PP, et al (2013). Dietarypatterns and colorectalcancer recurrence andsurvival: a cohort study. BMJ Open, 3, e002270. https://doi.org/10.1136/bmjopen-2012-002270

Cited by

  1. Helicobacter pylori and Pancreatic Cancer Risk: a Meta-analysis Based on 2,049 Cases and 2,861 Controls vol.15, pp.11, 2014, https://doi.org/10.7314/APJCP.2014.15.11.4449
  2. A Predictive Model for Evaluating Responsiveness to Pemetrexed Treatment in Patients with Advanced Colorectal Cancer vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5941
  3. Anti-Proliferation Effects and Molecular Mechanisms of Action of Tetramethypyrazine on Human SGC-7901 Gastric Carcinoma Cells vol.15, pp.8, 2014, https://doi.org/10.7314/APJCP.2014.15.8.3581
  4. and Extragastric Diseases vol.19, pp.10834389, 2014, https://doi.org/10.1111/hel.12159
  5. Expression of enoyl coenzyme A hydratase, short chain, 1, in colorectal cancer and its association with clinicopathological characteristics vol.2, pp.6, 2014, https://doi.org/10.3892/mco.2014.340
  6. Analysis of Small Fragment Deletions of the APC gene in Chinese Patients with Familial Adenomatous Polyposis, a Precancerous Condition vol.16, pp.12, 2015, https://doi.org/10.7314/APJCP.2015.16.12.4915
  7. Carcinoma Microsatellite Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Stage II Rectal Cancer vol.16, pp.4, 2015, https://doi.org/10.7314/APJCP.2015.16.4.1545
  8. Changes of Plasma Tumor Necrosis Factor α and C-Reactive Protein Levels in Patients with Hypertension Accompanied by Impaired Glucose Tolerance and their Clinical Significance vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3389
  9. Microarray Analysis of Long Non-coding RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells vol.16, pp.8, 2015, https://doi.org/10.7314/APJCP.2015.16.8.3395
  10. Pharmacological regimens for eradication of Helicobacter pylori: an overview of systematic reviews and network meta-analysis vol.16, pp.1, 2016, https://doi.org/10.1186/s12876-016-0491-7
  11. infection is an independent risk factor of early and advanced colorectal neoplasm vol.22, pp.3, 2017, https://doi.org/10.1111/hel.12377
  12. Characteristics and risk factors for sporadic non-ampullary duodenal adenocarcinoma vol.52, pp.11, 2017, https://doi.org/10.1080/00365521.2017.1369563
  13. Helicobacter pylori Antibody Reactivities and Colorectal Cancer Risk in a Case-control Study in Spain vol.8, pp.1664-302X, 2017, https://doi.org/10.3389/fmicb.2017.00888
  14. H. pylori infection and extra-gastroduodenal diseases vol.25, pp.1, 2018, https://doi.org/10.1186/s12929-018-0469-6
  15. infection and the risk of advanced colorectal neoplasia may differ according to age and cigarette smoking vol.23, pp.3, 2018, https://doi.org/10.1111/hel.12477