Asian Pacific Journal of Cancer Prevention

  • 제14권11호
  • /
  • Pages.6703-6707
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Between the XRCC3 Thr241Met Polymorphism and Cervical Cancer Risk: a Meta-analysis

  • Qin, Ling-Yan (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) ;
  • Chen, Xu (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) ;
  • Li, Ping (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) ;
  • Yang, Zheng (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University) ;
  • Mo, Wu-Ning (Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University)
  • 발행 : 2013.11.30
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초록

Background: Numerous epidemiological studies have been conducted to evaluate the association between variants of the DNA repair gene XRCC3 and cancer risk. Here we focused on one XRCC3 polymorphism and development of cervical cancer, performing a meta-analysis. Methods: The pooled association between the XRCC3 Thr241Met polymorphism and cervical cancer risk was assessed by odds ratios (ORs) and their 95% confidence intervals (95%CIs). Results: A total of 5 case-control studies met the inclusion criteria. The pooled ORs for the total included studies showed no association among homozygotes TT vs. CC: OR=1.93, 95%CI=0.68-5.49, P=0.22; dominant model TT+TC vs. CC: OR=1.37, 95%CI=0.90-2.06, P=0.14; and recessive model TT vs. TC+CC: OR=1.76, 95%CI=0.68-4.55, P=0.25, but might be a slight risk factor for cervical cancer in heterozygote contrast TT vs. CT: OR= 1.33, 95%CI=1.04-1.71, P=0.02. In subgroup analysis, significant associations were found for Asians under all genetic models. Conclusions: Our meta-analysis suggested the XRCC3 Thr241Met polymorphism might not act as a cervical cancer risk factor overall. However, in subgroup analysis, a significant association was found in Asians under all genetic models. The association should be studied with a larger, stratified population, especially for Asians.

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참고문헌

  1. Attia J, Thakkinstian A, D'Este C (2003). Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol, 56, 297-303. https://doi.org/10.1016/S0895-4356(03)00011-8
  2. DerSimonian R, Laird N 1986. Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88. https://doi.org/10.1016/0197-2456(86)90046-2
  3. Djansugurova LB, Perfilyeva AV, Zhunusova GS, et al (2013). The determination of genetic markers of age-related cancer pathologies in populations from Kazakhstan. Front Genet, 4, 70.
  4. Egger M, Davey Smith G., Schneider M, et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315, 629-34. https://doi.org/10.1136/bmj.315.7109.629
  5. Garcia-Closas M, Malats N, Real FX, et al (2006). Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Cancer Epidemiol Biomarkers Prev, 15, 536-42. https://doi.org/10.1158/1055-9965.EPI-05-0749
  6. Giuliano AR, Harris R, Sedjo RL, et al (2002). Incidence, prevalence, and clearance of type-specific human papillomavirus infections: The Young Women’s Health Study. J Infect Dis, 186, 462-9. https://doi.org/10.1086/341782
  7. He X, Ye F, Zhang J, et al (2008). Susceptibility of XRCC3, XPD, and XPG genetic variants to cervical carcinoma. Pathobiology, 75, 356-63. https://doi.org/10.1159/000164220
  8. Kadaja M, Silla T, Ustav E, et al (2009). Papillomavirus DNA replication - from initiation to genomic instability. Virology, 384, 360-8. https://doi.org/10.1016/j.virol.2008.11.032
  9. Lee SA, Lee KM, Park SK, et al (2007). Genetic polymorphism of XRCC3 Thr241Met and breast cancer risk: case-control study in Korean women and meta-analysis of 12 studies. Breast Cancer Res Treat, 103, 71-6. https://doi.org/10.1007/s10549-006-9348-z
  10. Liang HJ, Yan YL, Liu ZM, et al (2013). Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis. Asian Pac J Cancer Prev, 14, 4243-7. https://doi.org/10.7314/APJCP.2013.14.7.4243
  11. Haenszel W, Haensze W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  12. Mathonnet G., Labuda D, Meloche C, et al (2003). Variable continental distribution of polymorphisms in the coding regions of DNA-repair genes. J Hum Genet, 48, 659-64. https://doi.org/10.1007/s10038-003-0097-0
  13. Matullo G, Guarrera S, Carturan S, et al (2001). DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study. Int J Cancer, 92, 562-7. https://doi.org/10.1002/ijc.1228
  14. Perez LO, Crivaro A, Barbisan G, et al (2013). XRCC2 R188H (rs3218536), XRCC3 T241M (rs861539) and R243H (rs77381814) single nucleotide polymorphisms in cervical cancer risk. Pathol Oncol Res, 19, 553-8. https://doi.org/10.1007/s12253-013-9616-2
  15. Settheetham-Ishida W, Yuenyao P, Natphopsuk S, et al (2011). Genetic risk of DNA repair gene polymorphisms (XRCC1 and XRCC3) for high risk human papillomavirus negative cervical cancer in Northeast Thailand. Asian Pac J Cancer Prev, 12, 963-6.
  16. Spitz MR, Wei Q, Dong Q, et al (2003). Genetic susceptibility to lung cancer: the role of DNA damage and repair. Cancer Epidemiol Biomarkers Prev, 12, 689-98.
  17. Stuck AE, Rubenstein LZ, Wieland D (1998). Bias in meta-analysis detected by a simple, graphical test. Asymmetry detected in funnel plot was probably due to true heterogeneity. BMJ, 316, 469; author reply 470-1. https://doi.org/10.1136/bmj.316.7129.469
  18. Tebbs RS, Zhao Y, Tucke JD, et al (1995). Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene. Proc Natl Acad Sci U S A , 92, 6354-8. https://doi.org/10.1073/pnas.92.14.6354
  19. Tian X, Tian Y, Ma P, et al (2013). Association between the XRCC3 C241T polymorphism and lung cancer risk in the Asian population. Tumour Biol, 34, 2589-97. https://doi.org/10.1007/s13277-013-0806-z
  20. Wang SS, Bratti MC, Rodriguez AC, et al (2009). Common variants in immune and DNA repair genes and risk for human papillomavirus persistence and progression to cervical cancer. J Infect Dis, 199, 20-30. https://doi.org/10.1086/595563
  21. Wang Z, Zhang W (2013). Association between XRCC3 Thr241Met polymorphism and colorectal cancer risk. Tumour Biol, 34, 1421-9. https://doi.org/10.1007/s13277-012-0639-1
  22. Xiao HY, Wu WQ, Bao XM, et al (2009). The association between XRCC3 gene polymorphism and cervical cancer risk. Jilin Med, 31, 2731-2.

피인용 문헌

  1. Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6613
  2. Association between Single Nucleotide Polymorphisms in XRCC3 and Radiation-Induced Adverse Effects on Normal Tissue: A Meta-Analysis vol.10, pp.6, 2015, https://doi.org/10.1371/journal.pone.0130388
  3. Lack of Influence of an XRCC3 Gene Polymorphism on Oral Cancer Susceptibility: Meta-analysis vol.15, pp.23, 2015, https://doi.org/10.7314/APJCP.2014.15.23.10329
  4. rs861539 polymorphisms in cervical cancer patients vol.33, pp.1, 2018, https://doi.org/10.5301/ijbm.5000279