Asian Pacific Journal of Cancer Prevention

  • 제14권11호
  • /
  • Pages.6601-6604
  • /
  • 2013
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Associations Between Three Common MicroRNA Polymorphisms and Hepatocellular Carcinoma Risk in Chinese

  • Hao, Yu-Xia (Department of Infection, The First of Hospital of Shanxi Medical University) ;
  • Wang, Jun-Ping (Shanxi Provincial People's Hospital) ;
  • Zhao, Long-Feng (Department of Infection, The First of Hospital of Shanxi Medical University)
  • 발행 : 2013.11.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Aim: Associations between polymorphisms in miR-146aG>C, miR-196a2C>T and miR-499A>G and risk of HCC, and interaction with HBV infection in a Chinese population, were the target of the present research. Methods: The duplex polymerase-chain-reaction with confronting-two-pair primers (PCR-RFLP) was performed to determine the genotypes of the miR-146aG>C, miR-196a2C>T and miR-499A>G genotypes. Associations of polymorphisms with the risk of HCC were estimated by conditional logistic regression analysis. Results: Drinking, family history of cancer, HBsAg and HCV were risk factors for HCC. Multivariate regression analyses showed that subjects carrying the miR-196a2 CC genotype had significantly increased risk of HCC, with an adjusted OR (95% CI) of 2.18 (1.23-3.80). In addition, cases carrying the miR-196a2 C allele had a 1.64-fold increase in the risk for HCC (95%CI=1.03-2.49). The miR-196a2 CT and TT genotypes greatly significantly increased the risk of HCC in subjects with HBV infection, with adjusted ORs (95% CI) of 2.02 (1.12-3.68) and 2.69 (1.28-5.71), respectively. Conclusion: Our results demonstrate that miR-196a2 CC genotype and C allele have an important role in HCC risk in Chinese, especially in patients with HBV infection.

키워드

참고문헌

  1. Bartel DP (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116, 281-97. https://doi.org/10.1016/S0092-8674(04)00045-5
  2. Davila JA, Morgan RO, Shaib Y, et al (2004). Hepatitis C infection and the increasing incidence of hepatocellular carcinoma: a population-based study. Gastroenterology, 127, 1372-80. https://doi.org/10.1053/j.gastro.2004.07.020
  3. El-Serag HB, Rudolph KL (2007) Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology, 132, 2557-76. https://doi.org/10.1053/j.gastro.2007.04.061
  4. Esquela-Kerscher A, Slack FJ (2006). Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer, 6, 259-69. https://doi.org/10.1038/nrc1840
  5. Han Y, Pu R, Han X, et al (2013). Associations of pri-miR-34b/c and pre-miR-196a2 polymorphisms and their multiplicative interactions with hepatitis B virus mutations with hepatocellular carcinoma risk. PLoS One, 8, e58564. https://doi.org/10.1371/journal.pone.0058564
  6. Hu M, Zhao L, Hu S, Yang J (2013). The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLoS One, 8, e57012. https://doi.org/10.1371/journal.pone.0057012
  7. Huang S, He X (2011). The role of microRNAs in liver cancer progression. Br J Cancer, 104, 235-40. https://doi.org/10.1038/sj.bjc.6606010
  8. International Agency for Research on Cancer (2008). Globocan 2008 in China. http://globocan.iarc.fr/factsheet.asp.
  9. Jang MJ, Kim JW, Min KT, et al (2011). Prognostic significance of microRNA gene polymorphisms in patients with surgically resected colorectal cancer. Exp Ther Med, 2, 1127-32. https://doi.org/10.3892/etm.2011.321
  10. Kim WH, Min KT, Jeon YJ, et al (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504, 92-7. https://doi.org/10.1016/j.gene.2012.05.014
  11. Li XD, Li ZG, Song XX, Liu CF (2010). A variant in microRNA-196a2 is associated with susceptibility to hepatocellular carcinoma in Chinese patients with cirrhosis. Pathology, 42, 669-73. https://doi.org/10.3109/00313025.2010.522175
  12. Lim LP, Lau NC, Garrett-Engele P, et al (2005). Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature, 433, 769-73. https://doi.org/10.1038/nature03315
  13. Linhares JJ, Azevedo M Jr, Siufi AA, et al (2012). Evaluation of single nucleotide polymorphisms in microRNAs (hsa-miR-196a2 rs11614913 C/T) from Brazilian women with breast cancer. BMC Med Genet, 13, 119. https://doi.org/10.1186/1471-2350-13-119
  14. Ladeiro Y, Couchy G, Balabaud C, et al (2008). MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology, 47, 1955-63. https://doi.org/10.1002/hep.22256
  15. Li W, Xie L, He X, et al (2008). Diagnostic and prognostic implications of microRNAs in human hepatocellular carcinoma. Int J Cancer, 123, 1616-22. https://doi.org/10.1002/ijc.23693
  16. Masaki T (2009). MicroRNA and hepatocellular carcinoma. Hepatol Res, 39,751-2. https://doi.org/10.1111/j.1872-034X.2009.00572.x
  17. Pavlakis E, Papaconstantinou I, Gazouli M, et al (2013). MicroRNA gene polymorphisms in pancreatic cancer. Pancreatology, 13, 273-8. https://doi.org/10.1016/j.pan.2013.02.005
  18. Qi P, Dou TH, Geng L, et al (2010). Association of a variant in MIR 196A2 with susceptibility to hepatocellular carcinoma in male Chinese patients with chronic hepatitis B virus infection. Hum Immunol, 71, 621-6. https://doi.org/10.1016/j.humimm.2010.02.017
  19. Valencia-Sanchez MA, Liu J, Hannon GJ, et al (2006). Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev, 20, 515-24. https://doi.org/10.1101/gad.1399806
  20. Vinci S, Gelmini S, Pratesi N, et al (2011). Genetic variants in miR-146a, miR-149, miR-196a2, miR-499 and their influence on relative expression in lung cancers. Clin Chem Lab Med, 49, 2073-80.
  21. Wang F, Sun GP, Zou YF, et al (2013). Quantitative assessment of the association between miR-196a2 rs11614913 polymorphism and gastrointestinal cancer risk. Mol Biol Rep, 40, 109-16. https://doi.org/10.1007/s11033-012-2039-4
  22. Wang PY, Gao ZH, Jiang ZH, et al (2013). The Associations of Single Nucleotide Polymorphisms in miR-146a, miR-196a and miR-499 with Breast Cancer Susceptibility. PLoS One, 8, e70656. https://doi.org/10.1371/journal.pone.0070656
  23. Wei J, Zheng L, Liu S, et al (2013). MiR-196a2 rs11614913 T>C polymorphism and risk of esophageal cancer in a Chinese population. Hum Immunol, 74, 1199-205. https://doi.org/10.1016/j.humimm.2013.06.012
  24. Wilfred BR, Wang WX, Nelson PT (2007). Energizing miRNA research: a review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways. Mol Genet Metab, 91, 209-17. https://doi.org/10.1016/j.ymgme.2007.03.011
  25. Wu M, Jolicoeur N, Li Z, et al (2008). Genetic variations of microRNAs in human cancer and their effects on the expression of miRNAs. Carcinogenesis, 29, 1710-6. https://doi.org/10.1093/carcin/bgn073
  26. Wu XJ, Mi YY, Yang H, et al (2013). Association of the hsa-mir-499 (rs3746444) Polymorphisms with Gastric Cancer Risk in the Chinese Population. Onkologie, 36, 573-6. https://doi.org/10.1159/000355518
  27. Xiang Y, Fan S, Cao J, et al (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Mol Biol Rep, 39, 7019-23. https://doi.org/10.1007/s11033-012-1532-0
  28. Yuan Z, Zeng X, Yang D, Wang W, Liu Z (2013). Effects of common polymorphism rs11614913 in Hsa-miR-196a2 on lung cancer risk. PLoS One, 8, e61047. https://doi.org/10.1371/journal.pone.0061047
  29. Yu MC, Yuan JM (2004). Environmental factors and risk for hepatocellular carcinoma. Gastroenterology, 127, S72-8. https://doi.org/10.1016/j.gastro.2004.09.018
  30. Zhan X, Wu W, Han B, et al (2012). Hsa-miR-196a2 functional SNP is associated with severe toxicity after platinum-based chemotherapy of advanced nonsmall cell lung cancer patients in a Chinese population. J Clin Lab Anal, 26, 441-6. https://doi.org/10.1002/jcla.21544
  31. Zhang YG, Shi JX, Song CH, et al (2013). Association of mir-499 and mir-149 polymorphisms with cancer risk in the Chinese population: evidence from published studies. Asian Pac J Cancer Prev, 14, 2337-42. https://doi.org/10.7314/APJCP.2013.14.4.2337
  32. Zheng SQ, Li YX, Zhang Y, Li X, Tang H (2011). MiR-101 regulates HSV-1 replication by targeting ATP5B. Antiviral Res, 89, 219-26. https://doi.org/10.1016/j.antiviral.2011.01.008

피인용 문헌

  1. Clinical Significance of Joint Detection of Serum VEGF, SIL-2R and HGF in Patients with Primary Hepatocellular Carcinoma before and after Percutaneous Microwave Coagulation Therapy vol.15, pp.11, 2014, https://doi.org/10.7314/APJCP.2014.15.11.4545
  2. Clinical Study of Hepatectomy Combined with Jianpi Huayu Therapy for Hepatocellular Carcinoma vol.15, pp.14, 2014, https://doi.org/10.7314/APJCP.2014.15.14.5951
  3. Application of Lobaplatin in Trans-catheter Arterial Chemoembolization for Primary Hepatic Carcinoma vol.15, pp.2, 2014, https://doi.org/10.7314/APJCP.2014.15.2.647
  4. Association Analysis of Single Nucleotide Polymorphisms in miR-146a and miR-196a2 on the Prevalence of Cancer in Elderly Japanese: A Case-Control Study vol.15, pp.5, 2014, https://doi.org/10.7314/APJCP.2014.15.5.2101
  5. Clinical Significance of Upregulation of mir-196a-5p in Gastric Cancer and Enriched KEGG Pathway Analysis of Target Genes vol.16, pp.5, 2015, https://doi.org/10.7314/APJCP.2015.16.5.1781
  6. The role of microRNA-196a in tumorigenesis, tumor progression, and prognosis vol.37, pp.12, 2016, https://doi.org/10.1007/s13277-016-5430-2
  7. Association between four common microRNA polymorphisms and the risk of hepatocellular carcinoma and HBV infection vol.8, pp.3, 2014, https://doi.org/10.3892/ol.2014.2257
  8. Functional genetic variants in pre-miR-146a and 196a2 genes are associated with risk of lung cancer in North Indians vol.11, pp.15, 2015, https://doi.org/10.2217/fon.15.143
  9. Comprehensive assessment for miRNA polymorphisms in hepatocellular cancer risk: a systematic review and meta-analysis vol.38, pp.5, 2018, https://doi.org/10.1042/BSR20180712
  10. A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.00737
  11. MicroRNA-Related Polymorphisms in Infectious Diseases—Tiny Changes With a Huge Impact on Viral Infections and Potential Clinical Applications vol.9, pp.1664-3224, 2018, https://doi.org/10.3389/fimmu.2018.01316