Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Association Between p53 Arg72Pro Polymorphism and the Risk of Human Papillomavirus-related Head and Neck Squamous Cell Carcinoma: A Meta-analysis

  • Xia, Ling-Yun (The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University) ;
  • Zeng, Xian-Tao (Department of Oral and Maxillofacial Surgery, Center of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Li, Cheng (The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University) ;
  • Leng, Wei-Dong (Department of Oral and Maxillofacial Surgery, Center of Stomatology, Taihe Hospital, Hubei University of Medicine) ;
  • Fan, Ming-Wen (The Key Laboratory for Oral Biomedical Engineering of Ministry of Education, Hospital and School of Stomatology, Wuhan University)
  • Published : 2013.10.30
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Abstract

This study aimed to investigate the association between p53 Arg72Pro polymorphism and the risk of human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) by conducting meta-analysis. The PubMed database was searched for relevant studies until May 30, 2013. Relevant studies were selected and data were extracted by two independent authors. Overall, subgroup, and sensitivity analyses were then conducted using the Comprehensive Meta-Analysis v2.2 software. Wild-genotype ArgArg was considered as reference [odds ratio (OR) = 1.00]. Nine studies involving 1071 HNSCC cases were obtained. Meta-analysis results indicated no association between p53 Arg72Pro polymorphism and the risk of HPV-related HNSCC: for Pro/Pro vs. Arg/Arg, OR = 1.17, 95% confidence interval (CI) = 0.70-1.98; for Arg/Pro vs. Arg/Arg, OR = 1.25, 95% CI = 0.97-1.72; and for (Pro/Pro + Arg/Pro) vs. Arg/Arg, OR = 1.28, 95% CI = 0.95-1.70. These meta-analysis results were supported by subgroup and sensitivity analysis results. In conclusions, p53 Arg72Pro polymorphism is a potential marker of HP infection-related HNSCC rather than a susceptibility gene polymorphism.

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References

  1. Ara S, Lee PS, Hansen MF, et al (1990). Codon 72 polymorphism of the TP53 gene. Nucleic Acids Res, 18, 4961.
  2. Chen X, Sturgis EM, El-Naggar AK, et al (2008). Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers. Carcinogenesis, 29, 2120-25. https://doi.org/10.1093/carcin/bgn191
  3. Cortezzi SS, Provazzi PJ, Sobrinho JS, et al (2004). Analysis of human papillomavirus prevalence and TP53 polymorphism in head and neck squamous cell carcinomas. Cancer Genet Cytogenet, 150, 44-9. https://doi.org/10.1016/j.cancergencyto.2003.07.010
  4. Farris C, Petitte DM (2013). Head, neck, and oral cancer update. Home Healthc Nurse, 31, 322-8. https://doi.org/10.1097/NHH.0b013e3182932f01
  5. Funk GF, Karnell LH, Robinson RA, et al (2002). Presentation, treatment, and outcome of oral cavity cancer: a National Cancer Data Base report. Head Neck, 24, 165-80. https://doi.org/10.1002/hed.10004
  6. Galbiatti AL, Padovani-Junior JA, Maniglia JV, et al (2013). Head and neck cancer: causes, prevention and treatment. Braz J Otorhinolaryngol, 79, 239-47. https://doi.org/10.5935/1808-8694.20130041
  7. Gillison ML, Koch WM, Capone RB, et al (2000). Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst, 92, 709-20. https://doi.org/10.1093/jnci/92.9.709
  8. Hoffmann M, Scheunemann D, Fazel A, et al (2009). Human papillomavirus and p53 polymorphism in codon 72 in head and neck squamous cell carcinoma. Oncol Rep, 21, 809-14.
  9. Ji X, Neumann AS, Sturgis EM, et al (2008). p53 codon 72 polymorphism associated with risk of human papillomavirus-associated squamous cell carcinoma of the oropharynx in never-smokers. Carcinogenesis, 29, 875-9. https://doi.org/10.1093/carcin/bgn039
  10. Jiang N, Pan J, Wang L, et al (2013). No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer. Tumour Biol, 34, 587-96. https://doi.org/10.1007/s13277-012-0587-9
  11. Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol, 24, 2137-50. https://doi.org/10.1200/JCO.2005.05.2308
  12. Katiyar S, Thelma BK, Murthy NS, et al (2003). Polymorphism of the p53 codon 72 Arg/Pro and the risk of HPV type 16/18-associated cervical and oral cancer in India. Mol Cell Biochem, 252, 117-24. https://doi.org/10.1023/A:1025546610920
  13. Liang C, Marsit CJ, Houseman EA, et al (2012). Gene-environment interactions of novel variants associated with head and neck cancer. Head Neck, 34, 1111-8. https://doi.org/10.1002/hed.21867
  14. Moore SR, Johnson NW, Pierce AM, et al (2000). The epidemiology of mouth cancer: a review of global incidence. Oral Dis, 6, 65-74.
  15. Munafo MR, Flint J (2004). Meta-analysis of genetic association studies. Trends Genet, 20, 439-44. https://doi.org/10.1016/j.tig.2004.06.014
  16. Nagpal JK, Patnaik S, Das BR (2002). Prevalence of high-risk human papilloma virus types and its association with P53 codon 72 polymorphism in tobacco addicted oral squamous cell carcinoma (OSCC) patients of Eastern India. Int J Cancer, 97, 649-53. https://doi.org/10.1002/ijc.10112
  17. Oliveira C, Rinck-Junior JA, Lourenco GJ, et al (2013). Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma. J Cancer Res Clin Oncol, 139, 1199-206. https://doi.org/10.1007/s00432-013-1430-4
  18. Perrone F, Mariani L, Pastore E, et al (2007). p53 codon 72 polymorphisms in human papillomavirus-negative and human papillomavirus-positive squamous cell carcinomas of the oropharynx. Cancer, 109, 2461-65. https://doi.org/10.1002/cncr.22702
  19. Saini R, Tang TH, Zain RB, et al (2011). Significant association of high-risk human papillomavirus (HPV) but not of p53 polymorphisms with oral squamous cell carcinomas in Malaysia. J Cancer Res Clin Oncol, 137, 311-20. https://doi.org/10.1007/s00432-010-0886-8
  20. Scheckenbach K, Lieven O, Gotte K, et al (2004). p53 codon 72 polymorphic variants, loss of allele-specific transcription, and human papilloma virus 16 and/or 18 E6 messenger RNA expression in squamous cell carcinomas of the head and neck. Cancer Epidemiol Biomarkers Prev, 13, 1805-9.
  21. Storey A, Thomas M, Kalita A, et al (1998). Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature, 393, 229-34. https://doi.org/10.1038/30400
  22. Summersgill KF, Smith EM, Kirchner HL, et al (2000). p53 polymorphism, human papillomavirus infection in the oral cavity, and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 90, 334-9. https://doi.org/10.1067/moe.2000.107359
  23. Tsui IF, Poh CF, Garnis C, et al (2009). Multiple pathways in the FGF signaling network are frequently deregulated by gene amplification in oral dysplasias. Int J Cancer, 125, 2219-28. https://doi.org/10.1002/ijc.24611
  24. Wang Z, Sturgis EM, Zhang Y, et al (2012). Combined p53-related genetic variants together with HPV infection increase oral cancer risk. Int J Cancer, 131, E251-8. https://doi.org/10.1002/ijc.27335
  25. Wang Z, Sturgis EM, Guo W, et al (2012). Association of combined p73 and p53 genetic variants with tumor HPV16-positive oropharyngeal cancer. PLoS One, 7, e35522. https://doi.org/10.1371/journal.pone.0035522
  26. Warnakulasuriya S (2009). Global epidemiology of oral and oropharyngeal cancer. Oral Oncol, 45, 309-16. https://doi.org/10.1016/j.oraloncology.2008.06.002
  27. Xu T, Xu ZC, Zou Q, et al (2012). P53 Arg72Pro polymorphism and bladder cancer risk--meta-analysis evidence for a link in Asians but not Caucasians. Asian Pac J Cancer Prev, 13, 2349-54. https://doi.org/10.7314/APJCP.2012.13.5.2349
  28. Zhuo XL, Cai L, Xiang ZL, et al (2009). TP53 codon 72 polymorphism contributes to nasopharyngeal cancer susceptibility: a meta-analysis. Arch Med Res, 40, 299-305. https://doi.org/10.1016/j.arcmed.2009.03.006
  29. Zhuo XL, Li Q, Zhou Y, et al (2009). Study on TP53 codon 72 polymorphisms with oral carcinoma susceptibility. Arch Med Res, 40, 625-34. https://doi.org/10.1016/j.arcmed.2009.09.004

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