Reproductive and Developmental Biology

The Korean Society of Animal Reproduction (한국동물번식학회)
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Gene Co-Expression Network Analysis of Reproductive Traits in Bovine Genome

  • Lim, Dajeong (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA) ;
  • Cho, Yong-Min (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA) ;
  • Lee, Seung-Hwan (Hanwoo Experiment Station, National Institute of Animal Science, RDA) ;
  • Chai, Han-Ha (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA) ;
  • Kim, Tae-Hun (Division of Animal Genomics and Bioinformatics, National Institute of Animal Science, RDA)
  • Received : 2013.11.07
  • Accepted : 2013.11.19
  • Published : 2013.12.31
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Abstract

Many countries have implemented genetic evaluation for fertility traits in recent years. In particular, reproductive trait is a complex trait and need to require a system-level approach for identifying candidate genes related to the trait. To find the candidate gene associated with reproductive trait, we applied a weighted gene co-expression network analysis from expression value of bovine genes. We identified three co-expressed modules associated with reproductive trait from bovine microarray data. Hub genes (ZP4, FHL2 and EGR4) were determined in each module; they were topologically centered with statistically significant value in the gene co-expression network. We were able to find the highly co-expressed gene pairs with a correlation coefficient. Finally, the crucial functions of co-expressed modules were reported from functional enrichment analysis. We suggest that the network-based approach in livestock may an important method for analyzing the complex effects of candidate genes associated with economic traits like reproduction.

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References

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