Journal of Society of Preventive Korean Medicine (대한예방한의학회지)

Society of Preventive Korean Medicine (대한예방한의학회)
권호 표지

Influences of mineral contents in decoction water on the extraction efficiency of bioactive compounds from Eucommiae Cortex

전탕용수의 미네랄 함량이 두충의 유효성분 추출에 미치는 영향 분석

  • Received : 2013.09.09
  • Accepted : 2013.12.19
  • Published : 2013.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objective : Eucommiae Cortex is bark of Eucommia ulmoides Oliver, a deciduous tree native to China. Today, teas or herbal drugs made from E. ulmoides leaves are widely consumed as a healthy food especially in Eastern Asia including Japan, China and Korea. This study was aimed to verify the extraction efficiency of bioactive compounds from Eucommiae Cortex depending on characteristics of decoction water. Method : Six types of decoction water with various origin were prepared and the contents of minerals in water were analyzed by ICP-AES and ICP-MS. The contents of extracted bioactive compounds were analyzed by HPLC and the relationship between mineral contents and extracted bioactive compounds in the decoction water were analysed by multiple factor analysis. The decoction waters could be classified in three groups by hierarchical cluster analysis. Result : Extracted amounts of compounds in Eucommiae Cortex showed a positive relationship with Na, Si, K concentration in decoction water, while a negative relationship with Ca, Mg concentration. Conclusion : The study proved that the minerals in water influenced the extraction efficiency of bioactive compounds from Eucommiae Cortex.

Keywords

References

  1. 생약학교재편찬위원회, 생약학, 동명사, 2010.
  2. Son KH, Lee JM, Chang SY, Lee KS. Isolation and quantitative determination of geniposide from the Cortex of Eucommia ulmoides Oliver. Kor J Pharmacogn. 2001: 32(2):89-92.
  3. Li Y, Sato T, Metori K, Koike K, Che QM, Takhashi S. The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis. Biol Pharm Bull. 1998:21(12):1306-1310. https://doi.org/10.1248/bpb.21.1306
  4. Feng SM, Ni SF, Sun WJ. Preparative isolation and purification of the lignan pinoresinol diglucoside and liriodendrin from the bark of Eucommia ulmoides Oliv. by high speed countercurrent chromatography. J Liq Chromatogr Relat Technol. 2007 : 30(1):135-145. https://doi.org/10.1080/10826070601036324
  5. Luo XB, Ma M, Chen B, Yao SH, Wan ZT, Yang DJ, Hang HW. Analysis of nine bioactive compounds in Eucommia ulmoides Oliv. and their preparation by HPLC photodiode array detection and mass spectrometry. J Liq Chromatogr Relat Technol. 2004 : 27(1):63-81. https://doi.org/10.1081/JLC-120027086
  6. Bamba T, Fukusaki E, Nakazawa Y, Sato H, Ute K, Kitayama T, Kobayashi A. Analysis of long-chain polyprenols using supercritical fluid chromatography and matrix-assisted laser desorption ionization time-of-flight mass spectrometry. J Chromatogr A. 2003:995(1-2):203-207. https://doi.org/10.1016/S0021-9673(03)00498-9
  7. Joo OS, Nam SH. ACE Inhibitory Lignan Glycosides Isolated from Eucommia ulmoides Oliver. Kor J Life Sci. 2009:19(6):698-704. https://doi.org/10.5352/JLS.2009.19.6.698
  8. Li Y, Kamo S, Metori K, Koike K, Che QM, Takhashi S. The promoting effects of eucommiol from Eucommiae cortex on collagen synthesis. Bio Pharm Bull. 2000: 23(1):54-59. https://doi.org/10.1248/bpb.23.54
  9. Sih CJ, Ravikumar PR, Huang FC, Buckner C, Whitlock H JR. Letter:Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommiaulmoides,Oliver). J Am Chem Soc. 1976:98(17):5412-5413. https://doi.org/10.1021/ja00433a070
  10. Soka T. Encyclopedia of Chinese Drugs. Shanghai Science Technology Shogakukan Press. Tokyo. 1985:1964-1966.
  11. Zhou Y, Liang M, Li W, Li K, Li P, Hu Y, Yang Z. Protective effects of Eucommia ulmoides Oliv. bark and leaf on amyloid $\beta$-induced cytotoxicity. Environ Toxicol Pharmacol. 2009:28(3):342-349. https://doi.org/10.1016/j.etap.2009.05.012
  12. Lang C, Liu Z, Taylor HW, Baker DG. Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensiverat. Am J Chin Med. 2005:33(2) :215-230. https://doi.org/10.1142/S0192415X05002795
  13. Miura T, Nishiyama Y, Ichimaru M, Moriyasu M, Kato A, Hypoglycemic activity and structure-activity relationship of iridoidal glycosides. Biol Pharm Bull. 1966:19(1):160-161
  14. Lee MK, Kim MJ, Cho SY, Park SA, Park KK, Jung UJ, Park HM, Choi MS. Hypoglycemic effect of Du- zhong (Eucommia ulmoides Oliv.) leaves in streptozotocininduced diabetic rats. Diabetes Res Clin Prac. 2005:67(1):22-28. https://doi.org/10.1016/j.diabres.2004.05.013
  15. Park SA, Choi MS, Kim MJ, Jung UJ, Kim HJ, Park KK, Noh HJ, Park HM, Park YB, Lee JS, Lee MK. Hypoglycemic and hypolipidemic action of Du-zhong (Eucommia ulmoides Oliver) leaves water extract in C57BL/Ksj-db/dbmice. J Ethnopharm. 2006:107(3):412-417. https://doi.org/10.1016/j.jep.2006.03.034
  16. Sih CJ, Ravikumar PR, Huang FC, Buckner C, Whitlock HJ. Letter: Isolation and synthesis of pinoresinol diglucoside, a major antihypertensive principle of Tu-Chung (Eucommia ulmoides, Oliver). J Am Chem Soc. 1976:98(17):5412-5413. https://doi.org/10.1021/ja00433a070
  17. Kim YK, Kim CS, Cui X. The decocting and taking methods of herbal medicines. Kor J Ori Med. 2004:10(2):63-72.
  18. Kim MK, Sim JA, Eom HJ, Kim MH, Choi MK. Mineral contents in bottled natural water and estimation of their intake by Korean adults. J Kor Diet Assoc. 2010 :16(2):116-121.
  19. You EH, Lee JK, Kim SJ. A study on the water quality of domestic minera lwater. Kor J Env Health Soc. 1990:16(2):41-45.
  20. Kang JS, Park KJ, Wu E, Lee ES, Hwang GS. Lee HS, Kim YH, Comparative study of the Rhei Rhizoma by pattern analysis. Kor J Pharmacogn. 2008:39(3):179-185.
  21. Liu XJ, Hu J, Li ZY, Qin XM, Zhang LZ, Guo XQ. Species classification and quality assessment of Chaihu (Radix Bupleuri) based on high-performance liquid chromatographic fingerprint and combined chemometrics methods. Arch Pharm Res. 2011: 34(6):961-969. https://doi.org/10.1007/s12272-011-0613-2
  22. Jang YS, Chu VM, Lee KJ, Seo EY, Kim DH, Kang JS. Effects of the decoction water on the extraction of the bioactive compounds from rhubarb. Kor J Anal Sci Technol. 2011:24(1):38-44. https://doi.org/10.5806/AST.2011.24.1.038
  23. Metori K, Furutsu M, Takahashi S. The prevention effect of ginseng with Du-zhong leaf extract on plasma and protein metabolism in aging. Biol Pharm Bull. 1997: 20(3):237-242. https://doi.org/10.1248/bpb.20.237