Journal of Digital Convergence (디지털융복합연구)

The Society of Digital Policy and Management (한국디지털정책학회)
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The Effect of Red Ginseng Extracts on Blood Biochemical Parameters, Bone Density and Bone Inorganic Components in Ovariectomized Rats

홍삼추출물이 난소절제 흰쥐의 혈액 생화학적 지표, 골 밀도 및 골무기질에 미치는 영향

  • Kim, Byung-Weon (Dept. of Biomedical Laboratory Science, Gimcheon University) ;
  • Lee, Yoon-Bok (Dept. of Central Research Institute, Chung's Food Co. LTD.) ;
  • Park, Jae-Seung (Dept. of Biomedical Laboratory Science, Sohae University) ;
  • Park, Ji-Won (Dept. of Medical Management, Gimcheon University) ;
  • Hwang, Seock-Yeon (Dept. of Biomedical Laboratory Science, Daejeon University)
  • Received : 2013.07.21
  • Accepted : 2013.10.20
  • Published : 2013.10.28
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Abstract

We investigated the effect of red ginseng extracts on blood biochemical parameters, bone density and bone inorganic components etc. and data were analyzed by one-way ANOVA and Post-Hoc Test. In the results of our study, the level of albumin and HDL, Ca, P, Mg, and estradiol in blood, and the content of Ca, P, ash in femur were significantly increased in red ginseng treated group than in OVX group, and the level of ALP, AST, ALT, blood glucose, total cholesterol, triglyceride, LDL, creatinine, osteocalcin, and N-terminal telopeptide were significantly decreased in red ginseng treated group than in OVX group (p < 0.01). From these results, we knew that within the normal level, red ginseng extracts improved liver and kidney function, component of glucose and lipid in blood, bone density, bone ash and inorganic components in femur, and index related with bone metabolism.

홍삼추출물이 혈액생화학성분, 대퇴골의 골밀도 및 골무기질 등에 미치는 영향을 알아보기 위하여 난소절제(OVX) 흰쥐에 홍삼추출물을 투여하였으며, 실험결과는 일원변량분산분석과 Scheffe의 사후검정을 통하여 분석하였다. 그 결과 홍삼추출물은 OVX군에 비하여 혈중 알부민, HDL Ca, P, Mg 및 estradiol, 골밀도, 대퇴골의 회분, Ca 및 P을 유의하게 증가시키고, 혈중 ALP, AST, ALT, 혈당, 총콜레스테롤, 중성지질, LDL, creatinine, osteocalcin 및 N-terminal telopeptide를 유의하게 감소시켰다(p < 0.01). 이상의 결과로부터 홍삼추출물은 난소절제로 저하된 간과 신장의 기능, 혈중 당, 지질 및 무기질, 골밀도, 골무기질 함량 및 골다공증관련 대사지표들을 정상수준으로 회복시켜 준다는 것을 알 수 있었다.

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