Applied Microscopy

  • 제43권4호
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  • Pages.133-139
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  • 2013
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  • 2287-5123(pISSN)
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  • 2287-4445(eISSN)
한국현미경학회 (Korean Society of Microscopy)
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Effect of Pycnogenol on Skin Wound Healing

  • Jeong, Moon-Jin (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Jeong, Soon-Jeong (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Lee, Soo-Han (College of Veterinary Medicine, Konkuk University) ;
  • Kim, Young-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Baik-Dong (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Kim, Seung-Hyun (College of Veterinary Medicine, Chonnam National University) ;
  • Go, Ara (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Chang-Jong (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
  • 투고 : 2013.10.11
  • 심사 : 2013.10.29
  • 발행 : 2013.12.30
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초록

This study was carried out to investigate the effects of pycnogenol (PYC) on the cutaneous wound healing of the mice. The wounds were extracted on days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area, infiltrating inflammatory cells, wound contracture including collagen deposition. As the result, the wound area of PYC-treated group was larger than the control group on days 1 to 7. Inflammatory cells in the PYC-treated wounds were decreased at day 1 compared to the control wound tissue. From day 3 to 7, there was no significant difference between the control and the PYC-treated skin wounds. Though the degree of contraction in the PYC-treated group was lower than that of the control group from days 1 to 5, but appeared significantly higher on day 7. Compared to the control group, collagen accumulation in the PYC-treated group was higher than that of the control group from days 5 to 7. From this result, it may support the possibility that PYC would be useful agent for early inflammatory response and matrix remodeling phase of the skin wounds.

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