Applied Microscopy

Korean Society of Microscopy (한국현미경학회)
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Effect of Pycnogenol on Skin Wound Healing

  • Jeong, Moon-Jin (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Jeong, Soon-Jeong (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Lee, Soo-Han (College of Veterinary Medicine, Konkuk University) ;
  • Kim, Young-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Choi, Baik-Dong (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University) ;
  • Kim, Seung-Hyun (College of Veterinary Medicine, Chonnam National University) ;
  • Go, Ara (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Se Eun (College of Veterinary Medicine, Chonnam National University) ;
  • Kang, Seong-Soo (College of Veterinary Medicine, Chonnam National University) ;
  • Moon, Chang-Jong (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Jong-Choon (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Sung-Ho (College of Veterinary Medicine, Chonnam National University) ;
  • Bae, Chun-Sik (College of Veterinary Medicine, Chonnam National University)
  • Received : 2013.10.11
  • Accepted : 2013.10.29
  • Published : 2013.12.30
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Abstract

This study was carried out to investigate the effects of pycnogenol (PYC) on the cutaneous wound healing of the mice. The wounds were extracted on days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area, infiltrating inflammatory cells, wound contracture including collagen deposition. As the result, the wound area of PYC-treated group was larger than the control group on days 1 to 7. Inflammatory cells in the PYC-treated wounds were decreased at day 1 compared to the control wound tissue. From day 3 to 7, there was no significant difference between the control and the PYC-treated skin wounds. Though the degree of contraction in the PYC-treated group was lower than that of the control group from days 1 to 5, but appeared significantly higher on day 7. Compared to the control group, collagen accumulation in the PYC-treated group was higher than that of the control group from days 5 to 7. From this result, it may support the possibility that PYC would be useful agent for early inflammatory response and matrix remodeling phase of the skin wounds.

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References

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