Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Peripheral Giant Cell Granuloma in a Dog

개에서 거대세포 치은종의 증례

  • Cho, Eun-Sang (College of Veterinary Medicine, Chungnam National University) ;
  • Jeon, Sung-Joo (College of Veterinary Medicine, Chungnam National University) ;
  • Hong, Da-Hae (College of Veterinary Medicine, Chungnam National University) ;
  • Ryu, Si-Yun (College of Veterinary Medicine, Chungnam National University) ;
  • Jung, Ju-Young (College of Veterinary Medicine, Chungnam National University) ;
  • Park, Bae-Keun (College of Veterinary Medicine, Chungnam National University) ;
  • Son, Hwa-Young (College of Veterinary Medicine, Chungnam National University)
  • 조은상 (충남대학교 수의과대학) ;
  • 전성주 (충남대학교 수의과대학) ;
  • 홍다해 (충남대학교 수의과대학) ;
  • 류시윤 (충남대학교 수의과대학) ;
  • 정주영 (충남대학교 수의과대학) ;
  • 박배근 (충남대학교 수의과대학) ;
  • 손화영 (충남대학교 수의과대학)
  • Accepted : 2013.12.11
  • Published : 2013.12.31
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Abstract

A mass was detected in the oral cavity from a 18-year-old female miniature poodle dog. Grossly, the mass was soft to hard, red to purple, and $1.5{\times}1.5{\times}1cm$ in size. Histopathologically, the mass was composed of hyperplastic gingival epithelium, well-vascularized stroma, closely packed pleomorphic cells, and numerous giant cells with multiple nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, tumor cells were positive for alkaline phosphatase and cytokeratin 7, but not positive for CD68 unlike in human. The mass was diagnosed to peripheral giant cell granuloma in oral cavity through typical clinical and histopathological features.

18살의 암컷 푸들의 구강에서 종괴가 발견되었다. 육안적으로, 종괴는 단단하고, 적자색을 띠었으며, 크기는 $1.5{\times}1.5{\times}1cm$ 였다. 조직병리학적으로 종괴는 과증식된 잇몸 상피와 혈관이 잘 발달된 기질로 구성되어 있었으며, 다형 세포 및 퐁부한 호산성 세포질과 다수의 핵을 가진 많은 수의 거대 세포가 관찰되었다. 면역조직화학적으로, 종양 세포는 alkaline phosphatase와 cytokeratin 7에 양성 반응이었지만, CD68에 음성 반응이었다. 종괴는 전형적인 임상적, 조직병리학적인 특징에 의해 구강내 거대세포 치은종으로 진단되었다.

Keywords

References

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