Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Total Intravenous Anesthesia with Alfaxalone and Remifentanil in Dogs Premedicated with Xylazine or Acepromazine

개에서 Alfaxalone과 Remifentanil의 병용 지속주입 마취법 비교 평가

  • Hong, Young-Ok (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Yun, Sung-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Hyun (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Kwon, Young-Sam (Department of Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Jang, Kwang-Ho (Department of Surgery, College of Veterinary Medicine, Kyungpook National University)
  • 홍영옥 (경북대학교 수의과대학) ;
  • 윤성호 (경북대학교 수의과대학) ;
  • 이현 (경북대학교 수의과대학) ;
  • 권영삼 (경북대학교 수의과대학) ;
  • 장광호 (경북대학교 수의과대학)
  • Accepted : 2013.12.09
  • Published : 2013.12.31
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Abstract

The combinations of alfaxalone and remifentanil constant rate infusion in dogs premedicated with xylazine or acepromazine were compared. Ten beagle dogs were used and assigned randomly into 2 groups (5 dogs for each group). In group AAR, dogs were premedicated with 0.02 mg/kg of intravenous acepromazine at 15 min before induction. In group XAR, 1.1 mg/kg of intravenous xylazine was premedicated at 5 min before induction. In both groups, anesthesia was induced with alfaxalone and maintained with the combination of alfaxalone (6 mg/kg/hr, IV) and remifentanil (0.05 ${\mu}g/kg/min$, IV). bispectral index score was decreased after induction of anesthesia compared with baseline in both groups and no steep increase was observed during anesthesia. Bispectral index scores and electromyographs in group XAR were significant decreased compared with those in group AAR. Although the pulmonary depression in group XAR and tachycardia in group AAR should be considered to use these regimes, the combinations of alfaxalone and remifentanil constant rate infusion in dogs premedicated with xylazine or acepromazine provided adequate analgesia and anesthesia in this study.

본 실험에서는 xylazine 혹은 acepromazine으로 전마취된 비글 견에서 alfaxalone과 remifentanil의 병용 지속주입 마취법을 비교 평가 하였다. 10마리의 비글견을 각 5마리씩 두 군으로 나누었다. AAR군에서는 마취 유도 15분전에 acepromazine 0.02 mg/kg을 정맥 내 투여하였고 XAR 군에서는 마취 유도 5분 전에 xylazine 1.1 mg/kg을 정맥 내 투여하였다. Alfaxalone 2 mg/kg을 정맥 투여하여 마취를 유도하였으며, 6 mg/kg/hr의 alfaxalone과 0.05 ${\mu}g/kg/min$ remifentanil을 각각 정맥 내 지속주입하여 마취를 유지하였다. Bispectral index (BIS)는 마취 후 모든 시점에서 마취전과 비교해 감소하였으며 마취 중 급격한 증가는 관찰되지 않았다. 마취기 동안의 BIS와 근전도 값은 XAR군이 AAR군에 비해 확연히 감소되었다. Xylazine 혹은 acepromazine으로 전처치한 개에서 alfaxalone 과 remifentanil의 병용 지속주입 마취법은 적절한 진통작용을 나타내었다. XAR군에서는 호흡계 기능 저하가 있었고 AAR군에서는 빈맥이 유발되어 마취법 사용에 주의가 필요하나 임상에서 적용이 가능하다고 판단된다.

Keywords

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