DOI QR코드

DOI QR Code

New Bioactive Compounds from Korean Native Mushrooms

  • Kim, Seong-Eun (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Hwang, Byung Soon (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Song, Ja-Gyeong (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Lee, Seung Woong (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Lee, In-Kyoung (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University) ;
  • Yun, Bong-Sik (Division of Biotechnology and Advanced Institute of Environment and Bioscience, College of Environmental and Bioresource Sciences, Chonbuk National University)
  • Received : 2013.12.16
  • Accepted : 2013.12.16
  • Published : 2013.12.31

Abstract

Mushrooms are ubiquitous in nature and have high nutritional attributes. They have demonstrated diverse biological effects and therefore have been used in treatments of various diseases, including cancer, diabetes, bacterial and viral infections, and ulcer. In particular, polysaccharides, including ${\beta}$-glucan, are considered as the major constituents responsible for the biological activity of mushrooms. Although an overwhelming number of reports have been published on the importance of polysaccharides as immunomodulating agents, not all of the healing properties found in these mushrooms could be fully accounted for. Recently, many research groups have begun investigations on biologically active small-molecular weight compounds in wild mushrooms. In this mini-review, both structural diversity and biological activities of novel bioactive substances from Korean native mushrooms are described.

Keywords

References

  1. Zjawiony JK. Biologically active compounds from aphyllophorales (polypore) fungi. J Nat Prod 2004;67:300-10. https://doi.org/10.1021/np030372w
  2. Berger KJ, Guss DA. Mycotoxins revisited: part II. J Emerg Med 2005;28:175-83. https://doi.org/10.1016/j.jemermed.2004.08.019
  3. Yamasaki A, Shoda M, Iijima H, Nagai S, Wada J, Suzuki H, Chikazawa N, Tasaka T, Kameda C, Tanaka H, et al. A protein-bound polysaccharide, PSK, enhances tumor suppression induced by docetaxel in a gastric cancer xenograft model. Anticancer Res 2009;29:843-50.
  4. Li G, Kim DH, Kim TD, Park BJ, Park HD, Park JI, Na MK, Kim HC, Hong ND, Lim K, et al. Protein-bound polysaccharide from Phellinus linteus induces G2/M phase arrest and apoptosis in SW480 human colon cancer cells. Cancer Lett 2004;216:175-81. https://doi.org/10.1016/j.canlet.2004.07.014
  5. Zhou LD, Zhang QH, Zhang Y, Liu J, Cao YM. The shiitake mushroom-derived immuno-stimulant lentinan protects against murine malaria blood-stage infection by evoking adaptive immune-responses. Int Immunopharmacol 2009;9:455-62. https://doi.org/10.1016/j.intimp.2009.01.010
  6. Kumari M, Survase SA, Singhal RS. Production of schizophyllan using Schizophyllum commune NRCM. Bioresour Technol 2008;99:1036-43. https://doi.org/10.1016/j.biortech.2007.02.029
  7. Lee IK, Yun BS, Cho SM, Kim WG, Kim JP, Ryoo IJ, Koshino H, Yoo ID. Betulinans A and B, two benzoquinone compounds from Lenzites betulina. J Nat Prod 1996;59:1090-2. https://doi.org/10.1021/np960253z
  8. Kim WG, Lee IK, Kim JP, Ryoo IJ, Koshino H, Yoo ID. New indole derivatives with free radical scavenging activity from Agrocybe cylindracea. J Nat Prod 1997;60:721-3. https://doi.org/10.1021/np970150w
  9. Lee SJ, Yun BS, Cho DH, Yoo ID. Tylopeptins A and B, new antibiotic peptides from Tylopilus neofelleus. J Antibiot (Tokyo) 1999;52:998-1006. https://doi.org/10.7164/antibiotics.52.998
  10. Kim JP, Yun BS, Shim YK, Yoo ID. Inoscavin A, a new free radical scavenger from the mushroom lnonotus xeranticus. Tetrahedron Lett 1999;40:6643-4. https://doi.org/10.1016/S0040-4039(99)01406-9
  11. Lee IK, Seok SJ, Kim WK, Yun BS. Hispidin derivatives from the mushroom Inonotus xeranticus and their antioxidant activity. J Nat Prod 2006;69:299-301. https://doi.org/10.1021/np050453n
  12. Lee IK, Yun BS. Hispidin analogs from the mushroom Inonotus xeranticus and their free radical scavenging activity. Bioorg Med Chem Lett 2006;16:2376-9. https://doi.org/10.1016/j.bmcl.2006.01.121
  13. Lee IK, Jung JY, Seok SJ, Kim WG, Yun BS. Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis. Bioorg Med Chem Lett 2006; 16:5621-4. https://doi.org/10.1016/j.bmcl.2006.08.016
  14. Lee IK, Yun BS. Highly oxygenated and unsaturated metabolites providing a diversity of hispidin class antioxidants in the medicinal mushrooms Inonotus and Phellinus. Bioorg Med Chem Lett 2007;15:3309-14. https://doi.org/10.1016/j.bmc.2007.03.039
  15. Lee IK, Han MS, Lee MS, Kim YS, Yun BS. Styrylpyrones from the medicinal fungus Phellinus baumii and their antioxidant properties. Bioorg Med Chem Lett 2010;20:5459-61. https://doi.org/10.1016/j.bmcl.2010.07.093
  16. Lee IK, Lee JH, Yun BS. Polychlorinated compounds with $PPAR-{\gamma}$ agonistic effect from the medicinal fungus Phellinus ribis. Bioorg Med Chem Lett 2008;18:4566-8. https://doi.org/10.1016/j.bmcl.2008.07.034
  17. Lee SJ, Yeo WH, Yun BS, Yoo ID. Isolation and sequence analysis of new peptaibol, boletusin, from Boletus spp. J Pept Sci 1999;5:374-8. https://doi.org/10.1002/(SICI)1099-1387(199908)5:8<374::AID-PSC211>3.0.CO;2-X
  18. Hwang JS, Song KS, Kim WG, Lee TH, Koshino H, Yoo ID. Polyozellin, a new inhibitor of prolyl endopeptidase from Polyozellus multiplex. J Antibiot (Tokyo) 1997;50:773-7. https://doi.org/10.7164/antibiotics.50.773
  19. Lee HJ, Rhee IK, Lee KB, Yoo ID, Song KS. Kynapcin-12, a new p-terphenyl derivative from Polyozellus multiplex, inhibits prolyl endopeptidase. J Antibiot (Tokyo) 2000;53:714-9. https://doi.org/10.7164/antibiotics.53.714
  20. Kim SI, Park IH, Song KS. Kynapcin-13 and-28, new benzofuran prolyl endopeptidase inhibitors from Polyozellus multiplex. J Antibiot (Tokyo) 2002;55:623-8. https://doi.org/10.7164/antibiotics.55.623
  21. Yun BS, Lee IK, Kim JP, Yoo ID. Curtisians A-D, new free radical scavengers from the mushroom Paxillus curtisii. J Antibiot (Tokyo) 2000;53:114-22. https://doi.org/10.7164/antibiotics.53.114
  22. Lee IK, Jung JY, Kim YS, Rhee MH, Yun BS. p-Terphenyls from the fruiting bodies of Paxillus curtisii and their antioxidant properties. Bioorg Med Chem 2009;17:4674-80. https://doi.org/10.1016/j.bmc.2009.04.064
  23. Yun BS, Lee IK, Kim JP, Yoo ID. Two p-terphenyls from mushroom Paxillus panuoides with free radical scavenging activity. J Microbiol Biotechnol 2000;10:233-7.
  24. Yun BS, Lee IK, Kim JP, Yoo ID. Leucomentin-5 and -6, two new leucomentin derivatives from the mushroom Paxillus panuoides. J Antibiot (Tokyo) 2000;53:711-3. https://doi.org/10.7164/antibiotics.53.711
  25. Yun BS, Kang HC, Koshino H, Yu SH, Yoo ID. Suillusin, a unique benzofuran from the mushroom Suillus granulatus. J Nat Prod 2001;64:1230-1. https://doi.org/10.1021/np010138a
  26. Lee IK, Kim SE, Yeom JH, Ki DW, Lee MS, Song JG, Kim YS, Seok SJ, Yun BS. Daldinan A, a novel isoindolinone antioxidant from the ascomycete Daldinia concentrica. J Antibiot (Tokyo) 2012;65:95-7. https://doi.org/10.1038/ja.2011.109
  27. Lee IK, Yun BS, Han G, Cho DH, Kim YH, Yoo ID. Dictyoquinazols A, B, and C, new neuroprotective compounds from the mushroom Dictyophora indusiata. J Nat Prod 2002; 65:1769-72. https://doi.org/10.1021/np020163w
  28. Kim YH, Yun BS, Ryoo IJ, Kim JP, Koshino H, Yoo ID. Methoxylaricinolic acid, a new sesquiterpene from the fruiting bodies of Stereum ostrea. J Antibiot (Tokyo) 2006;59: 432-4. https://doi.org/10.1038/ja.2006.61
  29. Lee IK, Jang YW, Yu SH, Yun BS. New triterpene glucosides, oligoporins A-C, from Oligoporus tephroleucus protect DNA from Fenton reaction. Bioorg Med Chem Lett 2007;17:4906-9. https://doi.org/10.1016/j.bmcl.2007.06.034
  30. Jang YW, Lee IK, Kim YS, Lee S, Lee HJ, Yu SH, Yun BS. Xylarinic acids A and B, new antifungal polypropionates from the fruiting body of Xylaria polymorpha. J Antibiot (Tokyo) 2007;60:696-9. https://doi.org/10.1038/ja.2007.89
  31. Lee IK, Ki DW, Kim SE, Yeom JH, Kim YS, Yun BS. Pistillarin salt, a dicatecholspermidine family member from Gomphus floccosus, inhibits DNA single strand breakage by the Fenton reaction. J Korean Soc Appl Biol Chem 2011;54:312-5.
  32. Lee IK, Jung JY, Yeom JH, Ki DW, Lee MS, Yeo WH, Yun BS. Fomitoside K, a new lanostane triterpene glycoside from the fruiting body of Fomitopsis nigra. Mycobiology 2012;40:76-8. https://doi.org/10.5941/MYCO.2012.40.1.076
  33. Bhattarai G, Lee YH, Lee NH, Lee IK, Yun BS, Hwang PH, Yi HK. Fomitoside-K from Fomitopsis nigra induces apoptosis of human oral squamous cell carcinomas (YD-10B) via mitochondrial signaling pathway. Biol Pharm Bull 2012;35: 1711-9. https://doi.org/10.1248/bpb.b12-00297
  34. Kang HS, Jun EM, Park SH, Heo SJ, Lee TS, Yoo ID, Kim JP. Cyathusals A, B, and C, antioxidants from the fermented mushroom Cyathus stercoreus. J Nat Prod 2007;70:1043-5. https://doi.org/10.1021/np060637h