DOI QR코드

DOI QR Code

Polyclonal gammopathy related to renal bleeding in a peritoneal dialysis patient

  • Cho, Eun-Mi (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Moon, Hye-Hyun (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Hwang, Young-Ju (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Lee, Seung-Jin (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Ko, Cheol Woo (Department of Pediatrics, Kyungpook National University School of Medicine) ;
  • Cho, Min Hyun (Department of Pediatrics, Kyungpook National University School of Medicine)
  • 투고 : 2012.07.14
  • 심사 : 2012.10.25
  • 발행 : 2013.07.15

초록

Polyclonal gammopathy represents the diffuse activation of B cells and is usually related to inflammation or immune-related diseases. However, the mechanisms leading to polyclonal gammopathy are essentially speculative. Generally, infectious, inflammatory, or various other reactive processes may be indicated by the presence of a broad-based peak or band in the gamma region on serum protein electrophoresis results. A 15-year-old girl, who had been receiving peritoneal dialysis, presented with polyclonal gammopathy and massive gross hematuria. Renal artery embolization was performed, after which the continuous bleeding subsided and albumin-globulin dissociation resolved. This is a rare case of polyclonal gammopathy related to renal bleeding.

키워드

참고문헌

  1. Dispenzieri A, Gertz MA, Therneau TM, Kyle RA. Retrospective cohort study of 148 patients with polyclonal gammopathy. Mayo Clin Proc 2001;76:476-87. https://doi.org/10.4065/76.5.476
  2. Pezennec S, Gauthier F, Alonso C, Graner F, Croguennec T, Brule G, et al. The protein net electric charge determines the surface rheological properties of ovalbumin adsorbed at the air-water interface. Food Hydrocoll 2000;14:463-72. https://doi.org/10.1016/S0268-005X(00)00026-6
  3. O'Connell TX, Horita TJ, Kasravi B. Understanding and interpreting serum protein electrophoresis. Am Fam Physician 2005;71:105-12.
  4. Kyle RA. Sequence of testing for monoclonal gammopathies. Arch Pathol Lab Med 1999;123:114-8.
  5. Bida JP, Kyle RA, Therneau TM, Melton LJ 3rd, Plevak MF, Larson DR, et al. Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients. Mayo Clin Proc 2009;84:685-93. https://doi.org/10.4065/84.8.685
  6. Decaux O, Laurat E, Perlat A, Cazalets C, Jego P, Grosbois B. Systemic manifestations of monoclonal gammopathy. Eur J Intern Med 2009;20:457-61. https://doi.org/10.1016/j.ejim.2009.01.001
  7. Pollock CA, Mahony JF, Ibels LS, Caterson RJ, Waugh DA, Wells JV, et al. Immunoglobulin abnormalities in renal transplant recipients. Transplantation 1989;47:952-6. https://doi.org/10.1097/00007890-198906000-00007
  8. Passweg J, Thiel G, Bock HA. Monoclonal gammopathy after intense induction immunosuppression in renal transplant patients. Nephrol Dial Transplant 1996;11:2461-5. https://doi.org/10.1093/oxfordjournals.ndt.a027215
  9. Blaes AH, Morrison VA. Post-transplant lymphoproliferative disorders following solid-organ transplantation. Expert Rev Hematol 2010;3:35-44. https://doi.org/10.1586/ehm.09.76